A5079257265- Orthopedic Infections and Treatments
- Surgical site infection prevention
- Orthopaedic implants and arthroplasty
- Infection Control and Ventilation
- Antibiotic Use and Resistance
- Bacterial biofilms and quorum sensing
- Wound Healing and Treatments
- Infective Endocarditis Diagnosis and Management
- Sinusitis and nasal conditions
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Total Knee Arthroplasty Outcomes
- Medical Device Sterilization and Disinfection
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Nail Diseases and Treatments
- Burn Injury Management and Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Nasal Surgery and Airway Studies
- Medical and Biological Ozone Research
- Salivary Gland Tumors Diagnosis and Treatment
- Otolaryngology and Infectious Diseases
- Antifungal resistance and susceptibility
- Disaster Response and Management
Rothman Orthopaedics
2022-2024
Thomas Jefferson University Hospital
2024
Instituto Nacional de Rehabilitación
2021-2024
Universidad Nacional Autónoma de México
2021-2024
Rothman Institute
2022-2024
Thomas Jefferson University
2022-2024
Aim: This study aims to assess the changes in antimicrobial resistance among some critical and high-priority microorganisms collected previously during coronavirus disease 2019 (COVID-19) pandemic Mexico. Methods: We susceptibility data for from blood, urine, respiratory samples, all specimens, which pathogen may be considered a causative agent. Data were stratified compared two periods: versus 2020 second semester (prepandemic) (pandemic). Results: In analysis of 2020, blood increased...
Abstract Acinetobacter baumannii belongs to the ESKAPE group. It is classified as a critical priority group by World Health Organization and global concern on account of its capacity acquire develop resistance mechanisms multiple antibiotics. Data from United States indicates 500 deaths annually. Resistance this bacterium include enzymatic pathways such ß-lactamases, carbapenemases, aminoglycoside-modifying enzymes, decreased permeability, overexpression efflux pumps. A. has been...
The use of antibiotic-loaded bone cement (ALBC) to help reduce the risk infection after primary total knee arthroplasty (TKA) is controversial. There a paucity in vivo data on elution characteristics ALBC. We aimed determine whether antibiotic concentrations 2 commercially available ALBCs met minimum inhibitory concentration (MIC) and biofilm eradication (MBEC) for common infecting organisms.
Cutibacterium acnes has been described as the most common causative microorganism in prosthetic shoulder infections. Conventional anaerobic culture or molecular-based technologies are usually used for this purpose, but little to no concordance between these methodologies (k = 0.333 less) observed.(1) Is minimum C. load detection higher next-generation sequencing (NGS) than conventional culture? (2) What duration of incubation is necessary detect all loads?Five strains were tested study: Four...
Abstract The aim of this study was to assess the profile nasal microbiome and evaluate effect a specific decolonization solution on microbiome. We conducted randomized, placebo-controlled, parallel-group clinical 50 volunteers aged 18 years older. subjects were randomly assigned receive antiseptic solution, containing povidone-iodine as main ingredient, (n = 25) or control 25). Nasal swabs obtained before application (baseline) at 3 timepoints after (5 min, 2 h, 24 h). subjected next...
Bloodstream infection is one of the most important and increasing complications in patients with severe burns. Most species affecting this population are Gram-negative bacilli that exhibit antimicrobial resistance. We conducted study to determine susceptibility profile resistance mechanisms these bacterial infections their clinical associations on morbidity mortality. analyzed a retrospective cohort burn patients. All included had monobacterial blood stream during hospital stay. performed...
(1) Background: Pseudomonas aeruginosa is a Gram-negative bacterium with several intrinsic and acquired antimicrobial resistance mechanisms. The spread of carbapenemase-encoding genes, an mechanism, enables carbapenem in clinical settings. Detection the carbapenemase-producer strains urgent. Therefore, we aimed to characterize carbapenemase production P. at tertiary-care center. (2) Methods: We included (from August 2011 December 2018) towards least one carbapenem. Strains were isolated...
Abstract Background The most common organisms causing surgical site infection (SSI) are frequently found as part of the skin microbiota. Decolonization prior to a procedure has been shown be effective in reduction SSI. aim this prospective study was determine organism profile and evaluate effect application an antiseptic solution on microbiome. Methods A total 50 volunteers were recruited into study. After randomization, one arm treated with pre-saturated wipe containing benzalkonium...
Abstract Background Prevention of healthcare-associated infections (HAI), like surgical site (SSIs), has become a top priority for the medical community. Reduction bioburden on skin is proven strategy that minimizes SSI. All currently available antiseptic products, decolonization, are chlorhexidine gluconate (CHG) based. The rise in resistance organisms to CHG, increase reported cases CHG hypersensitivity, and lack activity against some common pathogens, prompted us design novel solution....
Abstract Background Prosthetic joint infection (PJI) is an infectious complication after total arthroplasty (TJA) with a high socioeconomic impact. Staphylococcus species attain for more than half of PJI cases. Biofilm formation and the development small colony variants (SCV) have proven to enhance chronic and/or relapsing bacterial infections. In this regard, better understanding these factors can help overcome other device-associated Thus, we aimed analyze clinical microbiological...
Abstract Background The presence of pathogenic bacteria in the anterior nares has gained substantial attention due to its association with an increased risk for surgical site infections. Nasal decolonization been shown reduce SSIs. Recent studies have suggested that profile nose microbiome is a determining factor susceptibility develop Therefore, this prospective clinical trial was set up study nasal and test effect specific solution on microbiome. Methods We conducted 50 individuals who...
Abstract Background Prevention of surgical site infections (SSIs) involves implementation numerous steps including ultraclean air in the operating room (OR). Despite all efforts, particles may exist and some these be live pathogens that can potentially cause subsequent SSI. This prospective study aimed to determine compare nature quantity microbes room, as detected from inlet flow an ultraviolet filtration unit, efficacy unit remove creating clean (the outlet flow). Methods was conducted at...
<title>Abstract</title> Prevention of surgical site infections involves implementation numerous steps including ultraclean air in the operating room (OR). We conducted this prospective study to determine and compare nature quantity microbes OR, as detected from inlet outlet flow an ultraviolet filtration unit. To do so, a unit with crystalline (C-UVC) was placed OR. The inflow outflow sampled at beginning conclusion each procedure. recorded surgical-related variables processed swabs for...
Abstract Background Approximately one-third of the prosthetic joint infections (PJIs) are polymicrobial. They difficult to treat and there is an urgent need clinical evidence that help guide current protocols. We aimed define characteristics outcomes patients with polymicrobial PJI. Methods conducted a retrospective cohort study PJI treated at referral hospital in Mexico City. Clinical data was retrieved analyzed. Time treatment failure, evaluated for all cases. Results identified 166 from...