A5079887676- Metabolomics and Mass Spectrometry Studies
- Genomics, phytochemicals, and oxidative stress
- Antibiotic Resistance in Bacteria
- Cancer, Hypoxia, and Metabolism
- Trypanosoma species research and implications
- Liver Disease Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Bacterial biofilms and quorum sensing
- Alcohol Consumption and Health Effects
- Insect Resistance and Genetics
- Bacterial Genetics and Biotechnology
- Synthesis and Biological Evaluation
- Biochemical effects in animals
- Protist diversity and phylogeny
- Cancer, Stress, Anesthesia, and Immune Response
- Bioactive Compounds and Antitumor Agents
- Seaweed-derived Bioactive Compounds
- Carcinogens and Genotoxicity Assessment
- Research on Leishmaniasis Studies
- Sirtuins and Resveratrol in Medicine
- Cancer Cells and Metastasis
- Antimicrobial Peptides and Activities
- Bacteriophages and microbial interactions
- Inflammatory mediators and NSAID effects
- RNA modifications and cancer
Instituto Nacional de Cardiología
2014-2023
Instituto Nacional de Cardiologia
2021
Universidad Nacional Autónoma de México
2014
Methanosarcina acetivorans, considered a strict anaerobic archaeon, was cultured in the presence of 0.4–1% O2 (atmospheric) for at least 6 months to generate air-adapted cells; further, biochemical mechanisms developed deal with were characterized. Methane production and protein content, as indicators cell growth, did not change cells respect under anoxia (control cells). In contrast, growth methane significantly decreased control exposed first time O2. Production reactive oxygen species 50...
This study shows that the non-steroidal anti-inflammatory drug (NSAID) celecoxib and its non-cyclooxygenase-2 (COX2) analogue dimethylcelecoxib (DMC) exert a potent inhibitory effect on growth of human cervix HeLa multi-cellular tumor spheroids (MCTS) when added either at beginning (“preventive protocol”; IC50 = 1 ± 0.3 nM for 10 2 DMC) or after spheroid formation (“curative 7.5 µM 32 DMC). These NSAID values were significantly lower than those attained in bidimensional cells (IC50 55 9 48...
To develop novel chemotherapeutic alternatives for the treatment of Chagas disease, in this study, a set new amino naphthoquinone derivatives were synthesised and evaluated vitro on epimastigote trypomastigote forms Trypanosoma cruzi strains (NINOA INC-5) J774 murine macrophages. The design considered incorporation nitrogenous fragments with different substitution patterns present compounds activity T. cruzi, and, thus, 19 simple manner. Compounds 2e 7j showed lowest IC50 values (0.43 µM...
Quorum sensing (QS) in Pseudomonas aeruginosa coordinates the expression of virulence factors, some which are used as public goods. Since their production is a cooperative behavior, it susceptible to social cheating non-cooperative QS deficient mutants use resources without investing production. Nevertheless, functional systems abundant; hence, mechanisms regulating amount should exist. Evidence that demonstrates tight relationship between and susceptibility bacteria against attack lytic...
Mitochondrial aldehyde dehydrogenase (ALDH2) has been proposed as a key enzyme in cardioprotection during ischemia-reperfusion processes. This proposal led to the search for activators of ALDH2 with aim develop cardioprotective drugs. Alda-1 was first activator identified and its effect extensively proven vivo; however, mechanism activation is not fully understood. A crystallographic study showed that binds entrance aldehyde-binding site; therefore, should essence be an inhibitor. In present...
The modulation of aldehyde dehydrogenase (ALDH) activity has been suggested as a promising option for the prevention or treatment many diseases. To date, only few activating compounds ALDHs have described. In this regard, N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide used to protect heart against ischemia/reperfusion damage. search new modulating ALDH molecules, binding capability different active site human class 1A1 (ALDH1A1) was analyzed by molecular docking, and their ability...
Genotoxicity in cells may occur different ways, direct interaction, production of electrophilic metabolites, and secondary genotoxicity via oxidative stress. Chloroform, dichloromethane, toluene are primarily metabolized liver by CYP2E1, producing reactive also produce stress the uncoupled CYP2E1 catalytic cycle. Additionally, GSTT1 participates dichloromethane activation. Despite metabolism these compounds adducts, their bone marrow micronucleus test is unclear. The objective this work was...
The major hurdles for successful cancer treatment are drug resistance and invasiveness developed by breast stem cells (BCSC).