A5016058732- Gut microbiota and health
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Cholesterol and Lipid Metabolism
- Metabolomics and Mass Spectrometry Studies
- Nutritional Studies and Diet
- Diet, Metabolism, and Disease
- Clostridium difficile and Clostridium perfringens research
- Bacteriophages and microbial interactions
- Dietary Effects on Health
- Alcohol Consumption and Health Effects
- RNA modifications and cancer
- Infant Nutrition and Health
- Lipid metabolism and disorders
- Nutrition, Genetics, and Disease
- Birth, Development, and Health
- Cancer, Lipids, and Metabolism
- Food Security and Health in Diverse Populations
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Pediatric Hepatobiliary Diseases and Treatments
- Streptococcal Infections and Treatments
- Digestive system and related health
- Diphtheria, Corynebacterium, and Tetanus
National Institute of Genomic Medicine
2013-2024
Universidad Nacional Autónoma de México
2010-2024
National Legal Medicine Institute
2018-2020
Instituto de Medicina Genómica
2017-2020
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2010-2012
Background Several studies have identified multiple obesity-associated loci mainly in European populations. However, their contribution to obesity other ethnicities such as Mexicans is largely unknown. The aim of this study was examine 26 single-nucleotide polymorphisms (SNP) a sample Mexican mestizos. Methods 9 SNPs biological candidate genes showing replications (PPARG, ADRB3, ADRB2, LEPR, GNB3, UCP3, ADIPOQ, UCP2, and NR3C1), 17 or near associated with first, second third wave GWAS...
In the last decade, increasing evidence has shown that changes in human gut microbiota are associated with diseases, such as obesity. The excreted/secreted proteins (secretome) of affect microbial composition, altering its colonization and persistence. Furthermore, it influences microbiota-host interactions by triggering inflammatory reactions modulating host's immune response. metatranscriptome is essential to elucidate which genes expressed under diseases. this regard, little known about...
Childhood obesity is a serious public health problem in Mexico. Adult gut microbiota composition has been linked to obesity, but few studies have addressed the role of childhood obesity.The aim this study compare obese and normal-weight children associate profiles with amino acid serum levels obesity-related metabolic traits.Microbial taxa relative abundance was determined by 16S rRNA sequencing 67 71 aged 6-12 years. Serum were measured mass spectrometry. Associations between composition,...
Background Gut microbiota, by influencing multiple metabolic processes in the host, is an important determinant of human health and disease. However, gut dysbiosis associated with complications shows inconsistent patterns. This likely driven factors shaping microbial composition that have largely been under-evaluated, at a population level, school-age children, especially from developing countries.Results Through characterization, 16S sequencing, largest population-based school-aged children...
Gut microbiota has been suggested to modulate circulating lipids. However, the relationship between gut and atherogenic dyslipidemia (AD), defined as presence of both low HDL-C hypertriglyceridemia, is not fully understood. Moreover, because obesity among main causes secondary AD, it important analyze effect composition on lipid profiles after a weight loss intervention. We compared microbial diversity taxonomic in patients with AD (n = 41) controls 38) sought correlations genera abundance...
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of disease. Increasing evidence indicates that gut microbiota can play an important role in pathophysiology NAFLD. Recently, several studies have tested predictive value microbiome profiles NAFLD progression; however, comparisons microbial signatures or non-alcoholic steatohepatitis (NASH) produced discrepant results, possibly due to ethnic and environmental factors. Thus, we aimed characterize metagenome composition patients...
Abstract Childhood obesity is associated with a number of metabolic abnormalities leading to increased cardiovascular risk. Metabolites can be useful as early biomarkers and new targets promote intervention beginning in school age. Thus, we aimed identify metabolomic profiles obesity-related traits. We used data from the Obesity Research Study for Mexican children (ORSMEC) Mexico City included case control (n = 1120), cross-sectional 554) longitudinal study 301) 6–12-year-old children....
Changes in the human gut microbiome are associated with obesity and metabolic syndrome, but role of virome both diseases remains largely unknown. We characterized dsDNA 28 school-aged children healthy normal-weight (NW, n = 10), (O, syndrome (OMS, 8), using metagenomic sequencing virus-like particles (VLPs) from fecal samples. The classification confirmed bacteriophages' dominance, mainly composed Caudovirales. Notably, phage richness diversity individuals O OMS tended to increase, while VLP...
Genome-wide association studies (GWAS) have identified copy number variants (CNVs) associated with obesity in chromosomal regions 1p31.1, 10q11.22, 11q11, 16p12.3, and recently 1p21.1, which contains the salivary amylase gene (AMY1). Recent evidence suggests this enzyme may influence gut microbiota composition through carbohydrate (mainly starch) degradation. The role of these CNVs has been scarcely explored Latino population, thus aim our study was to evaluate 16p12.3 1p21.1 921 Mexican...
Background Common variants rs6232 and rs6235 in the PCSK1 gene have been associated with obesity European populations. We aimed to evaluate contribution of these related traits Mexican children adults. Methodology/Principal Findings Rs6232 were genotyped 2382 individuals, 1206 1176 Minor allele frequencies 0.78% for 19.99% rs6235. was significantly childhood adult class III (OR = 3.01 95%CI 1.64–5.53; P 4×10−4 combined analysis). In addition, this SNP lower fasting glucose levels (P 0.01)...
Low HDL-C (high-density lipoprotein cholesterol) is the most frequent dyslipidemia in Mexicans, but few studies have examined underlying genetic basis. Our purpose was to identify variants associated with levels and cardiovascular risk Mexican population.A genome-wide association for 2335 identified four loci significance: CETP, ABCA1, LIPC, SIDT2. The SIDT2 missense Val636Ile variant replicated 3 independent cohorts (P=5.9×10−18 conjoint analysis). SIDT2/Val636Ile more Native American...
Abstract Background Elevations of circulating branched-chain amino acids (BCAA) are observed in humans with obesity and metabolic comorbidities, such as insulin resistance. Although it has been described that microbial metabolism contributes to the pool these acids, studies still scarce, particularly pediatric populations. Thus, we aimed explore whether early adolescents, gut microbiome was associated BCAA this way Methods Shotgun sequencing performed DNA from fecal samples 23 adolescents...
Maternal gut and breast milk (BM) are key in vertically transmission bacteria to infants, shaping their microbiota early life. Although the establishment of is known, role combined influence maternal factors newborn characteristics not explored. In this study we aimed assess BMI total body fat, age, delivery mode, sex on diversity composition BM (GM) mother- dyads. cross-sectional study, 986 pregnant women candidates, 53 participated, finally, 40 mother-newborn dyads exclusively...
crAssphage is a newly found phage described as the most abundant virus in human gut microbiome. The majority of proteins are unknown sequences databases, and its pathogenicity epidemiology humans yet unclear. Hence, being one phages microbiome more investigation at genomic level necessary to improve our understanding, especially Latin American population.In this article, we provide whole genome isolated from Mexican population, which was named Mexican-crAssphage. consists 96,283 bp, G+C...
Dietary fiber (DF) is a major substrate for the gut microbiota that contributes to metabolic health. Recent studies have shown diet-metabolic phenotype effect might be related individual microbial profiles or enterotypes. Thus, aim of this study was examine whether enterotypes modify association between DF intake and traits. This cross-sectional included 204 children (6-12 years old) 75 adults (18-60 old). Habitual estimated with Food Frequency Questionnaire biochemical, clinical...
Background VNN1 gene expression levels and the G-137T polymorphism have been associated with high density lipoprotein cholesterol (HDL-C) in Mexican American adults. We aim to evaluate contribution of variant HDL-C other metabolic traits prepubertal children. Methodology/Principal Findings mRNA were quantified peripheral blood leukocytes from 224 unrelated Mexican-Mestizo children aged 6–8 years (107 boys 117 girls) genotyped for (rs4897612). To account population stratification, a panel 10...
Abstract Objective The increased prevalence of childhood metabolic syndrome (MetS) is a public health issue. It has been shown that dysregulated bile acid (BA) profile could be involved in the development MetS, which gut microbiota have significant role BA levels. This study aimed to evaluate differences serum levels children with and without MetS whether these were associated microbial composition. Methods A total 100 aged 10 12 years enrolled this study, 42 (cases) 58 control participants....