A5085063283- Nutritional Studies and Diet
- Bone health and osteoporosis research
- Vitamin D Research Studies
- Cervical Cancer and HPV Research
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Reproductive tract infections research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genital Health and Disease
- Gout, Hyperuricemia, Uric Acid
- Alcohol Consumption and Health Effects
- Nutrition, Genetics, and Disease
- Bone Metabolism and Diseases
- Nutrition and Health in Aging
- Gut microbiota and health
- Genetic Associations and Epidemiology
- Vitamin C and Antioxidants Research
- Health and Lifestyle Studies
- Global Public Health Policies and Epidemiology
- Folate and B Vitamins Research
- Body Composition Measurement Techniques
- Metabolomics and Mass Spectrometry Studies
- Acne and Rosacea Treatments and Effects
Universidad Nacional Autónoma de México
2018-2025
Instituto Nacional de Salud Pública
2018-2023
Mexican Social Security Institute
2014-2018
Objective. To examine different health outcomes that are associated with specific lifestyle and genetic factors. Materials methods. From March 2004 to April 2006, a sample of employees from three academic institutions, as well their family members, were enrolled in the study after providing informed consent. At baseline follow-up (2010-2013), participants completed self-administered questionnaire, physical examination, provided blood samples. Results. A total 10 729 aged 6 94 years recruited...
<h3>Importance</h3> Triage tests enhance the efficiency cervical cancer screening based on human papillomavirus (HPV), but best approach for maximizing programmatic effectiveness is still uncertain, particularly in a real-world scenario. <h3>Objective</h3> To compare clinical performance of 6 triage strategies liquid-based cytology (LBC) and HPV-16 HPV-18 genotyping individually or combination as sequential to detect intraepithelial neoplasia (CIN) grade 2 higher among women with high-risk...
Gut microbiota has been suggested to modulate circulating lipids. However, the relationship between gut and atherogenic dyslipidemia (AD), defined as presence of both low HDL-C hypertriglyceridemia, is not fully understood. Moreover, because obesity among main causes secondary AD, it important analyze effect composition on lipid profiles after a weight loss intervention. We compared microbial diversity taxonomic in patients with AD (n = 41) controls 38) sought correlations genera abundance...
Abstract Summary In the Mexican population, low dietary antioxidant intake (DAI) is associated with reduced bone mineral density (BMD). A decline in DAI over time further contributes to BMD loss, particularly at total hip, femoral neck, and lumbar spine, a more pronounced effect women 45 years old. Purpose Bone remodeling, balancing resorption formation, crucial for health. Aging shifts this balance, reducing increasing osteoporosis risk. Reactive oxygen species (ROS) contribute loss through...
HPV-FASTER is an innovative public health intervention combining HPV vaccination and HPV-based screening in adult women at the same visit. FASTER-Tlalpan adapted combined strategy Tlalpan, Mexico City for aged 25-45 years. To understand barriers facilitators to participation a strategy, we conducted semi-structured interviews with 14 participants. We used constant comparative method analysis, as well socioecological model organize findings. At intrapersonal level, included belief that only...
Insulin resistance (IR) is a metabolic disorder that increasing worldwide and has been associated with several negative health outcomes. The aim of this study was to evaluate the relationship between different dietary patterns IR among Mexican children adolescents.We performed cross-sectional analysis on baseline data from adolescents aged 7–18 years participating in Health Workers Cohort Study. We included 916 both sexes. Fasting serum glucose insulin levels were determined by standardized...
Abstract Background Vigilant management of women with high-risk human papillomavirus (hrHPV) is necessary in cancer screening programs. To this end, we evaluated the performance S5 (targeting DNA methylation HPV16, HPV18, HPV31, HPV33, and gene EPB41L3 ) to predict cervical intraepithelial neoplasia grade 2 or higher (CIN2+) a sample hrHPV-infected referred colposcopy FRIDA Study, large trial Mexico. A nested case-control either by atypical squamous cells undetermined significance (ASCUS+)...
Risk of hyperuricemia is modified by genetic and environmental factors. Our aim was to identify factors associated with serum uric acid levels in Mexicans. A pilot Genome-wide association study GWAS performed a subgroup participants (n = 411) from the Health Workers Cohort Study (HWCS). Single nucleotide polymorphisms (SNPs) were validated all HWCS 1939) replicated independent children 1080) adult 1073) case-control studies. The meta-analysis whole replication samples identified three SLC2A9...
The effect of microbiota composition and its health on bone tissue is a novel field for research. However, their associations with mineral density (BMD) have not been established in postmenopausal women. present study investigates the relation diet, composition, serum metabolic profile women normal-BMD or low-BMD. Ninety-two Mexican were classified into (n = 34) low-BMD 58). V4 hypervariable region was sequenced using Miseq platform. Serum vitamin D determined by chemiluminescence...
Osteoporosis is a skeletal disease mainly affecting women over 50 years old and it represents serious public health problem because of the high socioeconomic burden. This characterized by deterioration bone microarchitecture, low mineral density (BMD), increased risk fragility fractures. study aimed to identify serum useful proteins as biomarkers for diagnosis and/or prognosis osteoporosis fracture risk. We collected 446 samples from postmenopausal aged ≥45 old. Based on BMD measurement, we...
The prevalence of hyperuricemia has doubled worldwide during the last few decades. substantial increase in sweetened beverage (SB) consumption also coincided with secular trend hyperuricemia. Recent studies do show that SB can induce However, association between and remains unclear. aim this study was to evaluate levels uric acid Mexican adults. We performed a cross-sectional analysis data from selected adults participating baseline assessment Health Workers Cohort Study. A total 6,705...
Genome-wide association studies in people with European ancestry suggest that polymorphisms genes involved vitamin D (VD) metabolism have an effect on serum concentrations of 25-hydroxyvitamin D. However, nothing is known about these populations Amerindian ancestry. Our aim was to evaluate the between genetic variants receptor (VDR) and binding protein (GC) genes, VD pathway, deficiency 689 unrelated Mexican postmenopausal women. We also described frequencies 355 women from different ethnic...
Diagnosis of developmental dysplasia the hip (DDH) mostly relies on physical examination and ultrasound, both methods are operator-dependent. Late detection can lead to complications in young adults. Current evidence supports involvement environmental genetic factors, such as single nucleotide variants (SNVs). Incorporating factors into diagnostic would be useful for implementing early management affected individuals. Our aim was analyze SNVs DDH patients. We included 287 cases 284 controls....
Background: Inconsistent epidemiological evidence between uric acid (UA) and bone mineral density (BMD) has been observed. Therefore, we evaluated the association UA BMD in Mexican adults. Methods: This analysis was conducted on 1423 participants from Health Workers Cohort Study. We explored cross-sectional associations using linear regression longitudinal fixed-effects by sex age groups (<45 ≥45 years). Results: In females <45 years old, showed that levels were positively associated with...
The triglyceride-glucose index (TyG index) is an indicator of insulin resistance that has been studied recently. relationship between and the risk hypertension documented previously. However, there limited knowledge regarding association TyG with incidence. This study aimed to evaluate changes in blood pressure (BP) incidence Mexican adults. analysis was performed using Health Workers Cohort Study data. estimated as Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2] divided into...
Abstract Background While soft drink intake is positively associated with weight gain, no previous study has investigated whether leisure-time physical activity modifies this association. We estimated the association between and body weight, explored if differed by levels of activity. Methods used data from health workers cohort study, a prospective Mexican adults (20 to 85y old), including 1268 their families, who were assessed at baseline (2004–2006) follow-up (2010–2012). (cola flavored...
Epidemiological studies suggest a relationship between total 25-hydroxyvitamin D [25(OH)D], adiposity, and metabolic traits. The bioavailability of 25(OH)D is regulated by the albumin, vitamin binding protein (VDBP), variants GC gene. Therefore, it not clear if bioavailable or free offer additional benefits compared to when estimating magnitude these associations. Our aim was evaluate association (total, bioavailable) with adiposity This cross-sectional study 1904 subjects from Health...
Abstract Meals are an important source of food intake, contributing to body weight and health status. Previous studies have examined the relationship between isolated mealtime behaviours metabolic syndrome (MetS). The aim this study was examine influence over time ten interrelated habits on risk developing MetS insulin resistance (IR) among Mexican adults. We conducted a prospective cohort with sample 956 workers. Mealtime Habits Quality (MHQ) scale is based four situations (availability...