A5014327442- Carbohydrate Chemistry and Synthesis
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Bone health and osteoporosis research
- Synthetic Organic Chemistry Methods
- Enzyme Catalysis and Immobilization
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Analytical Chemistry and Chromatography
- Bone health and treatments
- Synthesis and Catalytic Reactions
- Parathyroid Disorders and Treatments
- Glycosylation and Glycoproteins Research
- Legume Nitrogen Fixing Symbiosis
- Biochemical and Molecular Research
- Synthesis and Biological Evaluation
- Ion Transport and Channel Regulation
- Forensic Anthropology and Bioarchaeology Studies
- Insect-Plant Interactions and Control
- Microbial Metabolites in Food Biotechnology
- Insect Resistance and Genetics
- Global Public Health Policies and Epidemiology
- Synthesis of Indole Derivatives
- Natural Compound Pharmacology Studies
- Immune cells in cancer
University of California, Davis
2024
Université Paris-Saclay
2023
Assistance Publique – Hôpitaux de Paris
2023
Hôpital Raymond-Poincaré
2023
Universidad de Granada
2006-2021
Institución Universitaria Colegios de Colombia
2012-2015
University Hospital Complex Of Vigo
2013
Secretaria de Salud
2009
University of Oxford
2004-2007
Universidad Insurgentes
2005
An 18-month randomized double-blind study was conducted in postmenopausal women with osteoporosis to compare the effects of once-daily teriparatide 20 microg alendronate 10 mg on bone histomorphometry. Biopsies were obtained from 42 patients. Indices formation significantly higher after 6 or 18 months compared treatment.Alendronate and increased BMD, assessed by DXA, different mechanisms action, supported changes biochemical markers turnover. The purpose this cross-sectional explore...
Objective. To examine different health outcomes that are associated with specific lifestyle and genetic factors. Materials methods. From March 2004 to April 2006, a sample of employees from three academic institutions, as well their family members, were enrolled in the study after providing informed consent. At baseline follow-up (2010-2013), participants completed self-administered questionnaire, physical examination, provided blood samples. Results. A total 10 729 aged 6 94 years recruited...
Neuroinflammation is involved in the pathogenesis of almost every central nervous system disorder. As brain's innate immune cells, microglia fine tune their activity to a dynamic brain environment. Previous studies have shown that repeated bouts peripheral inflammation can trigger long-term changes microglial gene expression and function, form memory.
The mechanism of desensitization to PTH was examined in the isolated perfused canine kidney. Paired kidneys from six mongrel dogs were for 20–22 h vitro. Synthetic bovine PTH-(1–34) (1.5 μg/h) administered one each pair kidneys. Adenylate cyclase activity and receptor binding studied purified basolateral cortical membranes. specific synthetic PTH-(1– 34) reduced PTH-treated (maximum binding, 1.47 ± 0.43 fmol eq/μg protein vs. 3.28 0.66 control). These data correlated with a decrease...
Abstract The synthesis of three tetrahydroxyindolizidines and one tetrahydroxypyrrolizidine related to natural hyacinthacines B their biological evaluation as glycosidase inhibitors is reported. target molecules were obtained through highly stereoselective cycloadditions between sugriched allylic homoallylic alcohols. This allowed the installation a methyl group at C5 – common feature many with high control over stereoselectivity. new compounds inhibit amyloglucosidase from Aspergillus niger...
1,3-Dipolar cycloaddition reaction of nitrone 7 and chemo-enzymatically obtained alkenediols 12 13 has been used in the synthesis pentahydroxylated pyrrolizidines (8 10) indolizidines (9 11). The pyrrolizidinic indolizidinic skeletons were built after internal n-alkylation suitably functionalized pyrroloisoxazolidine intermediates by necessary protecting group manipulations. This method expands scope reactions new highly polyhydroxylated sugar-like alkaloids.
The mechanism of co-assembly different aromatic dipeptides has been studied using a combination microscopy and spectroscopy techniques. At an equimolar ratio, the kinetics process is favored giving rise to alternate copolymers.
Abstract Background Neuroinflammation is involved in the pathogenesis of almost every central nervous system disorder. As brain’s innate immune cells, microglia fine tune their activity to a dynamic brain environment. Previous studies have shown that repeated bouts peripheral inflammation can trigger long-term changes microglial gene expression and function, form memory. Methods Results In this study, we used multiple low-dose lipopolysaccharide (LPS) injections adult mice study acute...
Results of laboratory and field studies showed that adults Anthonomus grandis Boheman, captured in Leggett traps baited with grandlure or collected from surface leaf litter duff during the non-cotton season (September to April) 1978–1979 1979–1980 a subtropical area near Brownsville, Tex., were unique they remained physiologically active throughout winter. Boll weevils trapped even on days when minimum temperatures as low 1.5°C. Females caught fall sexually mature, mated, stored viable sperm...
The highly diastereoselective samarium diiodide and D(2)O-promoted conjugate reduction of homochiral (E)- (Z)-benzylidene isobutylidene diketopiperazines (E)-5,7 (Z)-6,8 has been demonstrated. This methodology allows the asymmetric synthesis methyl (2S,3R)-dideuteriophenylalanine 27 in > or = 95% de >98% ee, (2S,3R)- (2S,3S)-dideuterioleucine-(S)-phenylalanine dipeptides 37 38 moderate de, 66% 74% respectively. A mechanism is proposed to account for this process.
Sequential enolate alkylations of (S)-N(1)-methyl-5-methoxy-6-isopropyl-3,6-dihydropyrazin-2-one and (S)-N(1)-p-methoxybenzyl-5-methoxy-6-isopropyl-3,6-dihydropyrazin-2-one proceed with excellent levels diastereoselectivity (>90% de) affording quaternary α-amino acids in high enantiomeric excess (>98% ee) after deprotection hydrolysis.
Three weekly applications of 5.0 kg rubidium chloride (RbCl)/ha to corn plants beginning when the were at 1st tassel superior a single application 10 kg/ha made silks began dry for labeling earworm, Heliothis zea (Boddie), with Rb. The Rb contents larvae and moths from former treatment did not overlap those insects untreated plots. Fall armyworms, Spodoptera frugiperda (J. E. Smith), on also labeled using RbCl sprays. In study dispersal earworm field Rb, male collected in traps baited virgin...
High levels of diastereoselectivity are observed for benzylation the lithium enolates (S)-N,N′-bis-para-methoxybenzyl-3-iso-propyl-piperazine-2,5-dione, (S)-N(1)-para-methoxybenzyl-N(4)-methyl-3-iso-propyl-piperazine-2,5-dione and (S)-N(1)-methyl-N(4)-para-methoxybenzyl-3-iso-propyl-piperazine-2,5-dione. These data suggest that high diastereofacial selectivity alkylation these diketopiperazine templates is mainly a consequence relay stereochemical information from C(3) to C(6) via influence...
RESUMEN:El objetivo de este estudio es evaluar el índice facial tres poblaciones colombianas y proponer un nuevo método para identificar los biotipos morfológicos faciales teniendo en cuenta tipo ascendencia.Para esto, se tomaron las medidas Nasion a Gnation la distancia Bicigomática con calibrador digital grupos étnicos diferentes: 63 niños población Ticuna (Amazonas), 68 del municipio Puerto Tejada (Cauca) 65 Santiago Cali (Valle).Por medio prueba post hoc T2 Tamhane determinó que son...
A highly diastereoselective conjugate reduction using SmI2 and D2O has been demonstrated on a homochiral benzylidene diketopiperazine template, giving methyl (2S,3R)-N-acetyl-2-amino-2,3-dideuterio-3-phenylpropionate in 93% de 90% ee after deprotection, hydrolysis N-acetylation.