A5075996606- Supramolecular Self-Assembly in Materials
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Properties of Aromatic Compounds
- Molecular Junctions and Nanostructures
- Chemical Synthesis and Analysis
- Hydrogels: synthesis, properties, applications
- Enzyme Structure and Function
- Catalytic C–H Functionalization Methods
- Asymmetric Synthesis and Catalysis
- Carbohydrate Chemistry and Synthesis
- Luminescence and Fluorescent Materials
- Molecular spectroscopy and chirality
- Graphene research and applications
- Synthetic Organic Chemistry Methods
- DNA and Nucleic Acid Chemistry
- Quantum and electron transport phenomena
- Catalytic Cross-Coupling Reactions
- Porphyrin and Phthalocyanine Chemistry
- Advanced Sensor and Energy Harvesting Materials
- Polydiacetylene-based materials and applications
- Advanced Materials and Mechanics
- Asymmetric Hydrogenation and Catalysis
- Supramolecular Chemistry and Complexes
- Surface Chemistry and Catalysis
Universidad de Granada
2016-2025
Instituto de Investigación Biosanitaria de Granada
2019-2024
Instituto de Química Orgánica General
2015-2018
Universidad Autónoma de Madrid
2015
Massachusetts Institute of Technology
2009-2010
Institut de Chimie des Substances Naturelles
2006
Centre National de la Recherche Scientifique
2006
Painting a glass slide with branched or linear N,N-dodecyl methyl-polyethylenimines (PEIs) and certain other hydrophobic PEI derivatives enables it to kill influenza virus essentially 100% efficiency (at least 4-log reduction in the viral titer) within minutes, as well airborne human pathogenic bacteria Escherichia coli Staphylococcus aureus. For most of coating polyions, this virucidal action is shown be on contact, i.e., solely by polymeric chains anchored surface; for others, contribution...
Titanocene(<sc>iii</sc>)-based approaches have been demonstrated to be useful in the straightforward syntheses of many natural products from readily available starting materials.
Chiral stapled <italic>o</italic>-OPEs show excellent circular polarized luminescence responses (<italic>g</italic><sub>lum</sub> of 1.1 × 10<sup>−2</sup>) which can be modulated by carbophilic interactions.
In a general sense, molecular electronics (ME) is the branch of nanotechnology which studies application building blocks for fabrication electronic components. Among different types molecules, organic compounds have been revealed as promising candidates ME, due to easy access, great structural diversity and suitable mechanical properties. Thanks these useful capabilities, molecules used emulate devices at nanoscopic scale. this feature article, we present diverse strategies develop switches...
In this manuscript, we report the first synthesis of an organic monomolecular emitter, which behaves as a circularly polarized luminescence (CPL)-based ratiometric probe. The enantiopure helical ortho-oligo(phenylene)ethynylene (o-OPE) core has been prepared by new and efficient macrocyclization reaction. combination such o-OPE skeleton pyrene couple leads to two different CPL emission features in single structure whose ratio linearly responds silver(I) concentration.
In this paper, we have systematically studied how the replacement of a benzene ring by heterocyclic compound in oligo(phenyleneethynylene) (OPE) derivatives affects conductance molecular wire using scanning tunneling microscope-based break junction technique. We describe for first time OPE with central pyrimidine can efficiently link to gold electrode two pathways presenting different G values. demonstrated that effect is associated presence efficient conductive length: conventional...
Oleanolic acid (OA) and maslinic (MA) are pentacyclic triterpenic compounds that abound in industrial olive oil waste. These have renowned antimicrobial properties lack cytotoxicity eukaryotic cells as well resistance mechanisms bacteria. Despite these advantages, their activity has only been tested vitro, derivatives improving this not reported. In work, a set of 14 OA MA C-28 amide synthesized. Two derivatives, MA-HDA OA-HDA, increase the vitro parent while reducing toxicity most...
The inclusion of magnetic nanoparticles (MNP) in a hydrogel matrix to produce hydrogels has broadened the scope these materials biomedical research. Embedded MNP offer possibility modulate physical properties remotely and on demand by applying an external field. Moreover, they enable permanent changes mechanical hydrogel, as well alterations micro- macroporosity its three-dimensional (3D) structure, with associated potential induce anisotropy. In this work, behavior biocompatible...
Abstract The development of chiral compounds with enhanced chiroptical properties is an important challenge to improve device applications. To that end, optimization the electric and magnetic dipole transition moments molecule necessary. Nevertheless, relationship between chemical structure such quantum mechanical not always clear. That case moment ( m ) for which no general trends its have been suggested. In this work we propose a rationalization improving magnitude in different families...
The multivalent carbohydrate-carbohydrate interaction between membrane-anchored epitopes derived from the marine sponge Microciona prolifera has been explored by colloidal probe microscopy. An in situ coupling of sulfated and non-sulfated disaccharides to membrane-coated surfaces was employed mimic native cell-cell contacts.The dynamic strength homomeric self-association measured as a function calcium ions loading rate. A deterministic model used estimate basic energy landscape number...
A mild method for the selective esterification of primary alcohols is described. The use different phosphines, I(2), and imidazole allows a wide variety acids with excellent results. generation bulky phosphonium-carboxylate salt as intermediate could justify selectivity observed in this process. Additionally, amides also can be synthesized method.
Here we describe a new class of CPL switches based on oxophilic interactions between chiral sulfoxide-containing ortho-phenylene ethynylene (o-OPE) foldamers and cationic metals. These systems represent unique case combining high glum values (up to 0.7 × 10-2) quantum yields in both folded ON unfolded OFF states.
Novel iron nanoparticles-based supramolecular hydrogels are described. These materials present enhanced mechanical strength keeping a water-like diffusion behaviour.
The promising potential of bioorthogonal catalysis in biomedicine is inspiring incremental efforts to design strategies that regulate drug activity living systems. To achieve this, it not only essential develop customized inactive prodrugs and biocompatible metal catalysts but also the right physical environment for them interact enable production under spatial and/or temporal control. Toward this goal, here, we report first precursor potent broad-spectrum anticancer paclitaxel (a.k.a....
Fibrin hydrogels made by self-assembly of fibrinogen obtained from human plasma have shown excellent biocompatible and biodegradable properties are widely used in regenerative medicine. The process can be triggered under physiological conditions the action thrombin, allowing injection pregel mixtures that been as cell carriers, wound-healing systems, bio-adhesives. However, access to is expensive fibrin gels limited mechanical properties, which make them unsuitable for certain applications....
Chiral graphene hybrid materials have attracted significant attention in recent years due to their various applications the areas of chiral catalysis, separation and recognition, enantioselective sensing, etc. On other hand, are also known exhibit chirality-dependent spin transmission, commonly dubbed "chirality induced selectivity" or CISS. However, CISS properties largely unexplored. As such, it is not clear whether even a promising material for effect given its weak spin–orbit...
We report on the chemical design of chiral molecular junctions with stress-dependent conductance, whose helicity is maintained during stretching a single molecule junction due to stapling both ends inner helix. In reported compounds, different conductive pathways are observed, clearly conductance values and plateau-length distributions, attributed conformations helical structures. The large chiro-optical responses potential use these molecules as unimolecular spin filters have been...
The development of bio-MOFs or MOF biocomposites through the combination MOFs with biopolymers offers possibility expanding potential applications MOFs, making use more environmentally benign processes and reagents giving rise to a new generation greener bio-oriented composite materials. Now, increasing for biotechnological applications, protocols materials obtain novel compatible biomedical uses is needed. Herein, as proof concept, we have explored using short-peptide supramolecular...
Titanocene(III) chemistry has emerged in the last decades as an indispensable tool C-C bond-forming reactions. In this context, pinacol and related reactions allow stereoselective synthesis of vicinal diols. work, we present new applications these using starting materials aromatic ketones. Simple smooth reaction conditions have been developed applied for inter- intramolecular processes. We also describe that although Cp(2)TiCl is usually used a monoelectronic reducing agent, it can be...
A versatile Ti/Ni multimetallic protocol is described for the efficient catalysis of two different reactions, namely a Heck- and reductive-type cyclization alkyl iodides, in absence or presence water, respectively. Noteworthy, versatility Ti(III) chemistry allows an oxidative ending step under reductive conditions to give Heck-type products, good H-atom transfer capabilities Ti(III)-aqua complexes ensure cyclizations.
Intrinsically chiral double stapled ortho-oligo phenylene ethynylenes (o-OPEs) 1 show glum values up to 5.5 × 10-2, the second highest value ever observed for a simple organic molecule (SOM). DFT calculations of molecular spectra and properties encompassing electric magnetic dipole transition moments account these observations.
A new family of homochiral silver complexes based on carbophilic interactions with ortho-phenylene ethynylene (o-OPE) scaffolds containing up to two atoms are described. These compounds represent a unique class chirality at the metal. Chiral induction is inclusion chiral sulfoxides, which allow efficient transfer helically folded o-OPE, leading circularly polarized luminescence (CPL)- and vibrational circular dichroism (VCD)-active compounds. In presence silver(I) cations, dominate, promote...
The mechanism of self-assembly amphiphilic short peptides has been studied in detail by the combination multiparametric FLIM microscopy and single-molecule FLCS.