A5066635550- Supramolecular Self-Assembly in Materials
- Hydrogels: synthesis, properties, applications
- Polydiacetylene-based materials and applications
- Molecular Junctions and Nanostructures
- Chemical Synthesis and Analysis
- Machine Learning in Bioinformatics
- RNA Interference and Gene Delivery
- Porphyrin and Phthalocyanine Chemistry
- DNA and Nucleic Acid Chemistry
- Luminescence and Fluorescent Materials
- 2D Materials and Applications
- Antimicrobial Peptides and Activities
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Sensor and Energy Harvesting Materials
- Silk-based biomaterials and applications
- Electrospun Nanofibers in Biomedical Applications
- Protein Hydrolysis and Bioactive Peptides
- RNA and protein synthesis mechanisms
- Enzyme Catalysis and Immobilization
- Graphene research and applications
- Bone and Dental Protein Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Supramolecular Chemistry and Complexes
- Cephalopods and Marine Biology
Universidad de Granada
2019-2025
University of Trieste
2025
Instituto de Investigación Biosanitaria de Granada
2019-2023
The inclusion of magnetic nanoparticles (MNP) in a hydrogel matrix to produce hydrogels has broadened the scope these materials biomedical research. Embedded MNP offer possibility modulate physical properties remotely and on demand by applying an external field. Moreover, they enable permanent changes mechanical hydrogel, as well alterations micro- macroporosity its three-dimensional (3D) structure, with associated potential induce anisotropy. In this work, behavior biocompatible...
Supramolecular short-peptide assemblies have been widely used for the development of biomaterials with potential biomedical applications. These peptides can self-assemble in a multitude chiral hierarchical structures triggered by application different stimuli, such as changes temperature, pH, solvent, etc. The self-assembly process is sensitive to chemical composition peptides, being affected specific amino acid sequence, type, and chirality. resulting supramolecular chirality these...
Fibrin hydrogels made by self-assembly of fibrinogen obtained from human plasma have shown excellent biocompatible and biodegradable properties are widely used in regenerative medicine. The process can be triggered under physiological conditions the action thrombin, allowing injection pregel mixtures that been as cell carriers, wound-healing systems, bio-adhesives. However, access to is expensive fibrin gels limited mechanical properties, which make them unsuitable for certain applications....
The development of bio-MOFs or MOF biocomposites through the combination MOFs with biopolymers offers possibility expanding potential applications MOFs, making use more environmentally benign processes and reagents giving rise to a new generation greener bio-oriented composite materials. Now, increasing for biotechnological applications, protocols materials obtain novel compatible biomedical uses is needed. Herein, as proof concept, we have explored using short-peptide supramolecular...
Racemic assembly of minimalistic heterochiral tripeptides boosts their biocatalytic activity for ester hydrolysis. The amino acidic sequences are bioinspired and feature histidine (His) as a catalytically active residue, the diphenylalanine (Phe-Phe) motif to drive self-assembly into anisotropic nanostructures that gel. This study thus provides key insights design green biocatalysts with improved activity.
The mechanism of self-assembly amphiphilic short peptides has been studied in detail by the combination multiparametric FLIM microscopy and single-molecule FLCS.
Protein therapeutics have a major role in medicine that they are used to treat diverse pathologies. Their three-dimensional structures not only offer higher specificity and lower toxicity than small organic compounds but also make them less stable, limiting their
Racemic assembly of minimalistic heterochiral tripeptides boosts their biocatalytic activity for ester hydrolysis. The amino acidic sequences are bioinspired and feature histidine (His) as a catalytically active residue, the...
Anisotropy is an intrinsic feature of most the human tissues (e.g. muscle, skin or cartilage). Because this, there has been intense effort in search methods for induction permanent anisotropy hydrogels intended biomedical applications. The dispersion magnetic particles beads hydrogel precursor solution prior to cross-linking, combination with applied fields, which gives rise columnar structures, one recently proposed approaches this goal. We have gone even further and, paper, we show that it...
Most recent advances in the synthesis of supramolecular hydrogels based on low molecular weight gelators (LMWGs) have focused development novel hybrid hydrogels, combining LMWGs and different additives.The dynamic nature noncovalent interactions together with specific properties additives included formulation, allow these to present interesting features, such as stimuliresponsiveness, gel-sol reversibility, self-healing thixotropy, which make them very appealing for multiple biomedical...
The mechanism of co-assembly different aromatic dipeptides has been studied using a combination microscopy and spectroscopy techniques. At an equimolar ratio, the kinetics process is favored giving rise to alternate copolymers.
Hybrid hydrogels with a tunable structure–function relationship were prepared by simultaneous self-assembly and mineralization of aromatic short-peptides. Sub-stoichiometric Ca concentrations resulted in nanoapatite oriented along the peptide fiber.
Molecular functionalization of CNTs is a routine procedure in the field nanotechnology. However, whether and how these molecules affect spin polarization charge carriers are largely unknown. In this work we demonstrate that can indeed be induced two-dimensional (2D) CNT networks by "certain" signal routinely survives length scales significantly exceeding 1 μm. This result effectively connects area molecular spintronics with carbon-based 2D nanoelectronics. By using versatility peptide...
Abstract Peptide assembly is attractive not only to develop biotechnological tools and smart nanomaterials, but also treat pathologies in new ways. This Review focuses on recent progress made the exciting area pertaining interaction between peptide assemblies proteins. Earlier works aimed identify proteins able bind for therapeutics’ delivery biocompatible scaffolds. Recent advancements cover more applications that go beyond tissue regeneration biomaterials. On one hand, self‐assembling...
Transfer of chirality, or transmission asymmetric information from one system to another, plays an essential role in fundamental biological and chemical processes and, therefore, is for life. This phenomenon also holds immense potential spintronics the context chirality-induced spin selectivity (CISS). In CISS, spatial arrangement chiral molecules influences state electrons during charge-transfer processes. chirality achiral material a hybrid environment enables induction polarization...
We report the synthesis of a new set amphiphilic saddle-shaped heptagon-containing polycyclic aromatic hydrocarbons (PAHs) functionalized with tetraethylene glycol chains and their self-assembly into large two-dimensional (2D) polymers. An in-depth analysis mechanism at air/water interface has been carried out, proposed arrangement models are in good agreement molecular dynamics simulations. Quite remarkably, number disposition significantly influence PAHs conditionate packing under...