A5058517372- Molecular Biology Techniques and Applications
- Diet and metabolism studies
- Insect-Plant Interactions and Control
- Insect Resistance and Genetics
- RNA modifications and cancer
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Genomics and Phylogenetic Studies
- Carcinogens and Genotoxicity Assessment
- Epigenetics and DNA Methylation
- Forest Insect Ecology and Management
- Plant Parasitism and Resistance
- Genetics, Aging, and Longevity in Model Organisms
- Pesticide Exposure and Toxicity
- Entomopathogenic Microorganisms in Pest Control
- Tryptophan and brain disorders
- Drug-Induced Hepatotoxicity and Protection
- Diabetes and associated disorders
- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- Glaucoma and retinal disorders
- Trace Elements in Health
- Genetic factors in colorectal cancer
- Connexins and lens biology
- Birth, Development, and Health
Duke University Hospital
2023
Duke Medical Center
2023
Ecological Society of America
2019
University of California, Irvine
2017
Thermo Fisher Scientific (United States)
2015
CrossLife Technologies (United States)
2014
Washington State University Spokane
2006
Providence Sacred Heart Medical Center
2006
The University of Texas MD Anderson Cancer Center
2005
Applied Biomathematics (United States)
2005
Colon cancer has been viewed as the result of progressive accumulation genetic and epigenetic abnormalities. However, this view does not fully reflect molecular heterogeneity disease. We have analyzed both (mutations BRAF, KRAS, p53 microsatellite instability) alterations (DNA methylation 27 CpG island promoter regions) in 97 primary colorectal patients. Two clustering analyses on basis either profiling or a combination were performed to identify subclasses with distinct signatures....
Sporadic colorectal cancers often arise from a region of cells characterized by "field defect" that has not been well defined molecularly. DNA methylation proposed as candidate mediator this field defect. The repair gene O6-methylguanine-DNA methyltransferase (MGMT) is frequently methylated in cancer. We hypothesized MGMT could be one the mediators cancerization colon mucosa.We studied promoter three different bisulfite-based techniques tumor, adjacent mucosa, and non-adjacent mucosa 95...
Phosphine is a valuable fumigant to control pest populations in stored grains and grain products. However, recent studies indicate substantial increase phosphine resistance product pests worldwide. To understand the molecular bases of insects, we used RNA-Seq compare gene expression phosphine-resistant susceptible laboratory red flour beetle, Tribolium castaneum. Each population was evaluated as either phosphine-exposed or no (untreated controls) triplicate biological replicates (12 samples...
Objective: The discovery of telomere length as a biomarker cellular aging and correlate age-related disease has generated new field research in the biology healthy aging. Although most common method sample collection for is venous blood draw, less-invasive DNA methods are becoming more widely used. However, how relates across tissues derived from these poorly understood. current study first to characterize associations three methods: whole blood, finger prick dried spot, saliva. Methods:...
Three weekly applications of 5.0 kg rubidium chloride (RbCl)/ha to corn plants beginning when the were at 1st tassel superior a single application 10 kg/ha made silks began dry for labeling earworm, Heliothis zea (Boddie), with Rb. The Rb contents larvae and moths from former treatment did not overlap those insects untreated plots. Fall armyworms, Spodoptera frugiperda (J. E. Smith), on also labeled using RbCl sprays. In study dispersal earworm field Rb, male collected in traps baited virgin...
When host plants of Heliothis zea (Boddie) and H. virescens (F.) were studied in a 2500-acre area near Brownsville, Texas 1970, was found primarily on grain sorghum during the spring cotton June–August. Cotton primary cultivated , but fall, it also common such uncultivated bosts as Nicotiana repanda Willd., Verbena neomexicana (Gray) Small, Ruellia runyonii Tharp & Barkley; addition, Aubtilon trisulcatum (Jacq.) Urban tbe fall.
Mites associated with subcortical beetles feed and reproduce within habitats transformed by tree-killing herbivores. lack the ability to independently disperse among these habitats, thus have evolved characteristics that facilitate using insects as transport between resources. Studies on associations mites historically been beetle-centric, where an assemblage of mite species is characterized a single beetle species. However, available evidence suggests there may be substantial overlap...
Primary congenital glaucoma (PCG) is an autosomal recessive ocular trait caused by mutations in the gene for cytochrome P4501B1 (CYP1B1). Although PCG often considered to be fully penetrant, disease shows 50% penetrance some Saudi Arabian families. The familial segregation of nonpenetrance suggests a genetic modifier. Recently, tyrosinase (Tyr) deficiency was found worsen drainage structure/ocular dysgenesis phenotype Cyp1b1-/- mice, suggesting that Tyr modifier phenotype. In current study,...
Oil Soluble Deep Black BB® dye incorporated in the larval diet of tobacco budworm. Heliothis virescens (F.). and pink bollworm, Pectinophora gossypiella (Saunders), marked adults internally. Concentrations from 0.05 to 0.10% premixed with 0.30% cottonseed oil (COS) anti then mixed gave best internal dull blue tag bacco budworm; also, during 1st 5 days oviposition, eggs laid by female budworms fed 0.1% 0.6% CSO were light blue. Pink bollworm moths distinctly internally when larvae treated...
Abstract Type I I-compounds are bulky endogenous DNA modifications detectable by 32P postlabeling that exhibit age, species, tissue, genotype, gender, and diet dependence. Their formation appears unrelated to oxidative stress. In fact, several lines of indirect evidence suggest many type may represent normal functional modifications. For example, long-term dietary restriction (DR), which retards the development age-related diseases including cancer extends median maximum life spans,...
Abstract Objectives Insulin resistance is associated with elevations in plasma branched-chain amino acids (BCAAs). BCAAs compete aromatic including tryptophan for uptake into β cells. To explore relationships between and metabolism, adiposity, glucose tolerance, we compared urine metabolites overweight/obese youth type 2 diabetes (T2D) those nondiabetic lean youth. Methods Metabolites were measured 24-hour first-morning samples of 56 adolescents overweight/obesity, 42 T2D, 43 controls, aged...
Journal Article Overwintering Habitats of the Boll Weevil in Lower Rio Grande Valley, Texas Get access H. M. Graham, Graham Cotton Insects Research Laboratory, Agric. Res. Serv., USDA, Brownsville, TX 78520 Search for other works by this author on: Oxford Academic PubMed Google Scholar N. S. Hernandez, Jr., Jr. J. R. Llanes, Llanes A. Tamayo Environmental Entomology, Volume 7, Issue 3, 1 June 1978, Pages 345–348, https://doi.org/10.1093/ee/7.3.345 Published: 01 1978 history Received: 19...
Abstract Agricultural intensification impacts local arthropod communities. The temporal and spatial variation of agricultural environments can have a significant impact on insect pest populations, yet little work has been done to date the effect intra‐annual (within season) or spatiotemporal effects functional community composition. aim this research was evaluate landscape composition aphid community. To that end, we investigated following question: How do affect abundance, species richness,...
Integrated control against Heliothis spp. and other cotton pests was attempted in a large-scale field test 1967 near Santa Rosa, Texas. The results obtained when resistant strains of were planted nuclear polyhedral virus (Viron/H® Biotrol VTN®) applied for the boll worm, zea (Boddie), tobacco bud H. virescens (F.), compared favorably with those adjacent fields treated methyl parathion or combination ethyl parathion.
Abstract The presence of certain chromosomal rearrangements and the subsequent fusion gene derived from translocations has been implicated in a number cancers. Hundreds have described literature recently but need to efficiently detect further characterize these is growing exponentially. two main methods identify monitor translocations, fluorescent situ hybridization (FISH) comparative genomic (CGH) are challenging, labor intensive, information obtained limited, sensitivity rather low. Common...
Abstract DNA and RNA provide valuable information in order to detect differences such as chromosomal mutations imbalances gene expression. Common sample types for these analyses include surgical needle biopsies, which are very limited material making the downstream measurement of more than one analyte rather difficult. Obtaining another biopsy, using a different section or splitting can raise issues tumor heterogeneity. Even adjacent areas same tissue result profile so ability isolate...