A5016164645- Maternal Mental Health During Pregnancy and Postpartum
- Birth, Development, and Health
- Child and Adolescent Psychosocial and Emotional Development
- Infant Development and Preterm Care
- Stress Responses and Cortisol
- Neonatal and fetal brain pathology
- Neuroendocrine regulation and behavior
- Child Abuse and Trauma
- Neonatal Respiratory Health Research
- Early Childhood Education and Development
- Infant Health and Development
- Functional Brain Connectivity Studies
- Sleep and related disorders
- Advanced Neuroimaging Techniques and Applications
- Pregnancy and preeclampsia studies
- Anesthesia and Neurotoxicity Research
- Prenatal Substance Exposure Effects
- Infant Nutrition and Health
- Attention Deficit Hyperactivity Disorder
- Attachment and Relationship Dynamics
- Neuroscience of respiration and sleep
- Family Support in Illness
- Neural dynamics and brain function
- Gestational Diabetes Research and Management
- Preterm Birth and Chorioamnionitis
University of Denver
2016-2025
University of California, Irvine
2016-2025
Chapman University
2008-2024
Irvine University
2003-2024
University of Colorado Anschutz Medical Campus
2020
NeuroDevelopment Center
2013-2019
University of Colorado Boulder
2019
Lifespan
2014
Loma Linda University Health Care
2012
Children's Hospital of Orange County
2011
Disruptions to brain development associated with shortened gestation place individuals at risk for the of behavioral and psychological dysfunction throughout lifespan. The purpose present study was determine if benefit conferred by increased gestational length exists on a continuum across age spectrum among healthy children stable neonatal course. Neurodevelopment evaluated structural magnetic resonance imaging in 100 right-handed 6- 10-year-old born between 28 41 weeks Data indicate that...
The consequences of prenatal maternal stress for development were examined in 125 full‐term infants at 3, 6, and 12 months age. Maternal cortisol psychological state evaluated 5 times during pregnancy. Exposure to elevated concentrations early gestation was associated with a slower rate over the 1st year lower mental scores months. Elevated levels late gestation, however, accelerated cognitive higher pregnancy‐specific anxiety pregnancy independently 12‐month scores. These data suggest that...
Stress-related variation in the intrauterine milieu may impact brain development and emergent function, with long-term implications terms of susceptibility for affective disorders. Studies animals suggest limbic regions developing are particularly sensitive to exposure stress hormone cortisol. However, nature, magnitude, time course these effects have not yet been adequately characterized humans. A prospective, longitudinal study was conducted 65 normal, healthy mother–child dyads examine...
Prenatal exposure to inappropriate levels of glucocorticoids (GCs) and maternal stress are putative mechanisms for the fetal programming later health outcomes. The current investigation examined influence prenatal cortisol psychosocial on infant physiological behavioral responses stress.The study sample comprised 116 women their full term infants. Maternal plasma report stress, anxiety depression were assessed at 15, 19, 25, 31 36 + weeks' gestational age. Infant painful a heel-stick blood...
Because fetal brain development proceeds at an extremely rapid pace, early life experiences have the potential to alter trajectory of neurodevelopment, which may increase susceptibility for developmental and neuropsychiatric disorders. There is evidence that prenatal maternal stress anxiety, especially worries specifically related being pregnant, influence neurodevelopmental outcomes. In current prospective longitudinal study, we included 89 women whom serial data were available...
Significance The receipt of high-quality maternal care is an established promoter optimal neurodevelopment, but the processes by which influences development remain unclear. Using a cross-species approach, we probe possibility that predictability sensory signals from mother process behavior cognitive circuits within developing brain. This in accord with roles patterns information organization visual and auditory systems brain during sensitive periods. Our data support argument degree affects...
Information about the adverse effects of COVID-19 pandemic on adolescent and adult mental health is growing, yet impacts preschool children are only emerging. Importantly, environmental factors that augment or protect from multidimensional stressful influences emotional development young poorly understood.Depressive symptoms in 169 (mean age 4.1 years) were assessed with Preschool Feelings Checklist during a state-wide stay-at-home order Southern California. Mothers (46% Latinx) also...
The COVID-19 pandemic has been uniquely challenging for pregnant and postpartum women. Uncontrollable stress amplifies risk maternal depression anxiety, which are linked to adverse mother child outcomes. This study examined change in internalizing symptoms from before during the among women longitudinally, investigated moderation by loneliness other contextual factors.135 (Mage = 31.81; 26% Latina, 55% non-Hispanic White, 11% Black; 39% low-income) enrolled an existing prospective completed...
Abstract The effects of maternal antenatal and postnatal anxiety depression on infant negative behavioral reactivity were examined in a sample 22 mother‐infant pairs. Maternal assessed by standardized measures during the third trimester pregnancy postpartum. Infant responses to novelty using previously validated measure at 4 months age. prenatal, but not period, related novelty. These data illustrate that prenatal psychological state can exert persisting influences human behavior.
The human placenta expresses the genes for proopiomelanocortin and major stress hormone, corticotropin-releasing hormone (CRH), profoundly altering “fight or flight” system in mother fetus. As pregnancy progresses, levels of these hormones, including maternal cortisol, increase dramatically. These endocrine changes are important fetal maturation, but if altered (e.g., response to stress), they influence (program) nervous with long-term consequences. evidence indicates that exposure elevated...
The consequences of exposure to prenatal maternal anxiety for the development child temperament were examined in a sample 120 healthy, 2-year-old children. Prenatal state and pregnancy-specific (PSA) measured five times during pregnancy, was again at 2 years post partum. Child using Early Childhood Behavior Questionnaire. relationship between trajectory across gestation negative affectivity evaluated hierarchical linear growth curve modeling. Higher PSA 13 17 weeks associated with increased...