A5038274741- Bone health and osteoporosis research
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Vitamin D Research Studies
- Nutritional Studies and Diet
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Trypanosoma species research and implications
- Bone health and treatments
- Adipose Tissue and Metabolism
- Vitamin C and Antioxidants Research
- IL-33, ST2, and ILC Pathways
- Gastrointestinal motility and disorders
- Studies on Chitinases and Chitosanases
- GDF15 and Related Biomarkers
- Nutrition, Genetics, and Disease
- Circular RNAs in diseases
- Cancer-related gene regulation
- Folate and B Vitamins Research
- Peroxisome Proliferator-Activated Receptors
- Wnt/β-catenin signaling in development and cancer
- Psoriasis: Treatment and Pathogenesis
- Family Business Performance and Succession
- Health and Lifestyle Studies
Universidad Estatal del Valle de Ecatepec
2023-2025
National Institute of Genomic Medicine
2014-2025
Universidad de Ecatepec
2023
Universidad Privada del Estado de México
2021-2022
Abstract Psoriasis is a chronic skin disorder marked by fast cell growth, leading to thick, red, scaly patches. MicroRNAs are small, non-coding RNA molecules that play crucial role in post-transcriptional gene regulation. This study investigates miR-16-5p, miR-21-5p, and miR-155-5p expression psoriasis EVs assesses their biomarker potential, exploring associated target genes pathways via bioinformatics. A cross-sectional case-control included 40 patients, with blood samples collected EDTA...
Background: Rejection continues to be the main cause of renal graft loss. Currently, gold standard for diagnosis is an allograft biopsy; however, because it time-consuming, costly, and invasive, pursuit novel biomarkers has gained interest. Variation in expressions miRNAs currently considered a probable biomarker acute rejection. This study aimed determine whether miR-150-5p serum related microvascular damage patients with antibody-mediated rejection (ABMR). Methods: A total 27 who underwent...
Abstract Summary In the Mexican population, low dietary antioxidant intake (DAI) is associated with reduced bone mineral density (BMD). A decline in DAI over time further contributes to BMD loss, particularly at total hip, femoral neck, and lumbar spine, a more pronounced effect women 45 years old. Purpose Bone remodeling, balancing resorption formation, crucial for health. Aging shifts this balance, reducing increasing osteoporosis risk. Reactive oxygen species (ROS) contribute loss through...
Abstract Background Chagas disease is considered important and presents intense inflammatory fibrotic processes induced by the perpetuation of parasite in affected tissues organs. Therefore, it necessary to inquire about host defense attack mechanisms have a more detailed knowledge disease. MicroRNAs are found blood, extracellular vesicles. These small regulators gene expression involved physiological pathological both mammals parasites. Several microRNAs deregulated chagasic heart disease,...
MicroRNAs (miRNAs or miRs) are a class of short non-coding RNAs that serve an important regulatory role in living organisms. These molecules associated with multiple biological processes and potential biomarkers diseases. The present study aimed to further identify miRNAs differentially expressed circulating monocytes (CMCs) from postmenopausal Mexican-Mestizo women. Microarray analyses using Affymetrix miRNA 4.0 Human Genome U133 Plus 2.0 arrays were performed 6 normal osteoporotic women,...
To identify genetic variants influencing bone mineral density (BMD) in the Mexican-Mestizo population, we performed a GWAS for femoral neck (FN) and lumbar spine (LS) postmenopausal women. In discovery sample, 300,000 SNPs were genotyped cohort of 411 women seven analyzed replication (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>420</mml:mn></mml:math>). The combined results meta-analysis from samples identified two loci, RMND1...
Osteoporosis, a disease characterized by low bone mineral density (BMD), is an important health problem in Mexico. BMD highly heritable trait, with heritability estimates of 50-85%. Several candidate genes have been evaluated to identify those involved variation and the etiology osteoporosis. This study investigated possible association single-nucleotide polymorphisms (SNPs) MEF2C, SOST JAG1 (BMD) postmenopausal Mexican-Mestizo women. Four hundred unrelated women were included study. Risk...
Objective: This study aimed to investigate the association of seven single nucleotide polymorphisms (SNPs) on RMND1, CCDC170, and ESR1 genes with osteoporosis or hip fracture in a postmenopausal Mexican population.Methods: We included group 400 women from Health Workers Cohort Study Institute Social Security. As replication sample, we recruited 423 National Rehabilitation. Demographic data were collected through structured questionnaire. Bone mineral density was assessed using dual X-ray...
Bone formation is a dynamic process directed by osteoblast activity. The transition from the proliferation to differentiation stage during maturation involves downregulation of Wnt/β-catenin signaling pathway, and extracellular antagonists are important for regulation Wnt signaling. However, expression levels in these stages human have not been fully elucidated. Therefore, aim present study was investigate osteoblast-like cell lines. results demonstrated an overlap between differential...
Introduction Understanding the genetic factors contributing to variations in bone mineral density (BMD) and vitamin D could provide valuable insights into pathogenesis of osteoporosis. This study aimed evaluate association single nucleotide variants MARK3 (rs11623869), PLCB4 (rs6086746), GEMIN2 (rs2277458) with BMD Mexican women. Methods The gene-gene interaction was evaluated these serum 25(OH)D levels BMD. A risk score (GRS) created on basis three variants. Genotyping performed using...
Objective: Bone is a tissue that constantly remodeled to adjust the microarchitecture and maintain mechanical needs of bone through balance resorption formation processes. Alterations in these processes can lead development different diseases, such as osteoarthritis osteoporosis. In recent years, it has been shown acupuncture an effective treatment for pain, physical dysfunctions, immune system, so stimulation points could affect genes associated with inflammatory and, therefore, To analyze...
Background: Chronic chagasic cardiomyopathy is the most severe clinical manifestation of Chagas disease, which affects approximately seven million people worldwide. Latin American countries bear highest burden, with greatest morbidity and mortality rates. Currently, diagnostic methods do not provide information on risk progression to stages disease. Recently, microRNAs (miRNAs) have been proposed as promising tools for monitoring This study aimed analyze expression profiles miRNAs miR-1,...
Peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear transcription factor with role in gene expression changes associated to lipid metabolism. PPARα polymorphic variants have been previously correlated serum profile but Mexico, there no previous report about that association. For this reason, the aim of study was investigate relationship between and lipids level Mexican population.Two-hundred forty women from Northeast region Mexico were included study. Anthropometric...
RESUMENLa nefropatía diabética (ND) es una de las principales complicaciones crónicas la diabetes mellitus (DM) y causas enfermedad renal terminal.En los últimos años diferentes estudios han revelado el papel del microbioma intestinal en desarrollo crónica DM.Los metabolitos producidos por tales como lipopolisacáridos, ácidos grasos cadena corta N-óxido trimetilamina se identificado mediadores diafonía microbiana.La desregulación resulta deficiencia estos otros subproductos derivados...
Introducción. La nefropatía diabética (ND) es una enfermedad caracterizada por la secreción de albuminuria superior a 300 mg/dL que puede conducir al desarrollo renal crónica avanzada (ERCA). Objetivo. Identificar genes regulados miRNAs asociados con ND y su papel en patogénesis través un análisis In sílico. Material Métodos. A del uso microarreglos bioinformáticos se identificaron potenciales blancos los miRNAs; hsa-miR-126-3p, miR-320a-3p miR-1288-3p. Estos fueron sometidos vías...
Función de las hormonas sexuales en la homeostasis del hueso y su papel el desarrollo osteoporosis masculina: Una revisión narrativa.
Oxidative stress is essential in developing multiple bone metabolism diseases, including osteoporosis. Single-nucleotide variants (SNVs) have been associated with oxidative stress, promoting an imbalance between the production of reactive oxygen species and ability to neutralize them, it has reported that antioxidant nutrient intake can influence mineral density (BMD). This work reports association stress-related SNVs (GPX1-rs1050450, rs17650792, SOD2-rs4880, CAT-rs769217), BMD, intake. The...