A5049350564- Systemic Lupus Erythematosus Research
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- T-cell and B-cell Immunology
- Systemic Sclerosis and Related Diseases
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Atrial Fibrillation Management and Outcomes
- Rheumatoid Arthritis Research and Therapies
- Liver Disease Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Inflammasome and immune disorders
- SARS-CoV-2 and COVID-19 Research
- Vitamin C and Antioxidants Research
- Cardiac Valve Diseases and Treatments
- Hormonal Regulation and Hypertension
- Cardiovascular Syncope and Autonomic Disorders
- Long-Term Effects of COVID-19
- Cardiac Arrhythmias and Treatments
- Cardiac Fibrosis and Remodeling
- Bone and Joint Diseases
- Adipose Tissue and Metabolism
- Heart Rate Variability and Autonomic Control
- Nitric Oxide and Endothelin Effects
- Cardiac electrophysiology and arrhythmias
Instituto Nacional de Cardiología
2015-2025
Instituto Nacional de Cardiologia
2008-2024
Universidad Autónoma Metropolitana
2014-2023
Radboud University Nijmegen
2019
Radboud University Medical Center
2019
Mexican Social Security Institute
2014
Hospital General De Zona
2014
Universidad del Valle de México
2013
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2007
The type 2 coronavirus causes severe acute respiratory syndrome (SARS-CoV-2) and produces pneumonia with pulmonary alveolar collapse. In some cases it also sepsis septic shock. There is no specific treatment for disease 2019 (COVID-19). Vitamin C (Vit C), E E), N-acetylcysteine (NAC) Melatonin (MT) increase the intracellular content of GSH, kidnap free radicals protect DNA, proteins in cytosol lipids cell membranes. Pentoxifylline (Px) has anti-inflammatory activities. Here we evaluate...
The kidnapping of the lipid metabolism host’s cells by severe acute respiratory syndrome (SARS-CoV-2) allows virus to transform into optimal machines for its assembly and replication. Here we evaluated changes in fatty acid (FA) profile participation activity desaturases, plasma patients with pneumonia SARS-CoV-2. We found that SARS-CoV-2 alters FA host. Changes are characterized variations desaturases lead a decrease total (TFA), phospholipids (PL) non-esterified acids (NEFAs). These...
Background and aim: Here, we assess the effect of adjuvant antioxidant therapies in septic shock patients with organ dysfunction their on enzymatic non-enzymatic systems. Methods: Randomized clinical trial run between 2018 2022. One hundred thirty-one were included five groups 25, 27, 24, 26 29 each. Group 1 received vitamin C (Vit C), 2 E E), 3 n-acetylcysteine (NAC), 4 melatonin (MT) group 5 no treatment. All antioxidants administered orally or through a nasogastric tube for days as an to...
Abstract 'Rhupus' is a rare condition sharing features of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). If rhupus distinctive entity, an overlap between RA SLE or subset currently debated. This study was performed to explore the prevalence antibodies against cyclic citrullinated peptides (anti-CCP antibodies) in rhupus. Patients meeting American College Rheumatology criteria for RA, SLE, both were included. Clinical radiographic recorded sera searched anti-CCP antibodies,...
Gestational diabetes (GD) is a multifactorial disease involving hormonal, metabolic, and inflammatory factors, among which cytokines such as interleukin-6 (IL-6), interleukin-18 (IL-18), monocyte chemoattractant protein-1 (MCP-1) play key roles in immune regulation tissue repair during pregnancy postpartum. The aim of this study was to compare serum IL-6, IL-18, MCP-1 concentrations postpartum women with without GD analyze sociodemographic characteristics pregnancy-related complications. A...
Background Type 4 cardiorenal syndrome (CRS) involves cardiovascular alterations caused by chronic kidney disease (CKD). Fibroblast growth factor-23 (FGF23), carboxy-terminal propeptide of procollagen type I (PIP), and parathyroid hormone (PTH) have been proposed as biomarkers pathological cardiac remodeling in CKD. In contrast, it has suggested that MicroRNA 221 a cardioprotective role. Available evidence shows that, 12 months after transplantation (KT), CRS reverts only half the patients....
Abstract Background Chagas disease is considered important and presents intense inflammatory fibrotic processes induced by the perpetuation of parasite in affected tissues organs. Therefore, it necessary to inquire about host defense attack mechanisms have a more detailed knowledge disease. MicroRNAs are found blood, extracellular vesicles. These small regulators gene expression involved physiological pathological both mammals parasites. Several microRNAs deregulated chagasic heart disease,...
Cellular homeostasis is lost or becomes dysfunctional during septic shock due to the activation of inflammatory response and deregulation oxidative stress. Antioxidant therapy administered alongside standard treatment could restore this homeostasis. We included 131 patients with who were treated vitamin C (Vit C), E E), N-acetylcysteine (NAC), melatonin (MT), in a randomized trial. Organ damage quantified by Sequential Failure Assessment (SOFA) score, we determined levels Interleukins (IL)...
Abstract Background In sepsis, tumor necrosis factor (TNF) is the key triggering respiratory burst, tissue injury and disseminated coagulation. Anti-TNF strategies based on monoclonal antibodies or F(ab’) 2 fragments have been used in sepsis with contradictory results. Immunoglobulin new antigen receptors (IgNAR) are a unique subset of consisting five constant ( C NAR) one variable domains V NAR). NAR smallest, naturally occurring, antibody-based immune recognition units, having potential...
Major depressive disorder patients present chronic stress and decreased immunity. The Wistar-Kyoto rat (WKY) is a strain in which the hypothalamic-pituitary-adrenal axis overactivated. To determine whether induces changes corticosterone levels splenic lymphoid tissue, 9-week-old male rats were subject to restraint (3 h daily), chemical (hydrocortisone treatment, 50 mg/Kg weight), mixed (restraint plus hydrocortisone), or control treatment (without stress) for 1, 4, 7 weeks. serum by RIA...
The aim of this study was to assess associations between serum type III (λ) interferons (IFN-λ) and disease activity in systemic lupus erythematosus (SLE).Serum levels IFN-λ1, IFN-λ2, IFN-λ3 were measured 93 SLE patients 67 healthy individuals. with overall activity, organ-specific damage, SLE-related antibodies assessed.Median IFN-λ1 0 pg/mL (range, 0-510 pg/mL) (0-171 pg/mL; P = 0.814) control subjects, respectively. These figures (0-28 (0-43 0.659) for as well 83 (0-965 42 (0-520 0.002)...
Acute coronary syndromes (ACS) may be triggered by acute infections. Systemic production of interferon gamma (IFN-γ) is induced during infection and regulates the matrix metalloproteinases (MMPs) their inhibitors (TIMPs), both important in plaque stability. This study evaluates effect IFN-γ on MMPs/TIMP-1 ratio cultured monocytes from 30 patients with stable artery disease (CAD), unstable angina (UA) or non-ST-segment elevation myocardial infarction (NSTEMI), healthy blood donors....
Endotoxic shock (ExSh) and cecal ligature puncture (CLP) are models that induce sepsis. In this work, we investigated early immunologic histopathologic changes induced by ExSh or CLP in female male mice. Remarkable results showed females supported twice the LD100 of LPS for males, survival CFU counts were similar between genders, high circulating levels mice low IgM anti-LPS males. serum TNF IL-6 increased first 6 h, males at 12 h. liver mice, 1.5 IL-1 TGFβ1 throughout study h decreased 6-12...
Takayasu's arteritis (TA) is an idiopathic chronic inflammatory disease that causes occlusion of large arteries, but little known about whether affected patients are characterized by endothelial dysfunction, different high-density lipoproteins (HDL) subclasses and paraoxonase-1 (PON1) activity.In the present study, 30 with TA, age- gender-matched volunteers (controls) 15 essential hypertension were studied. Flow-mediated vasodilation (FMD) maximal blood flow velocity, assessed in brachial...
Objective. The aim of this study was to investigate whether a core echocardiography-based definitions pulmonary hypertension (PH), as proposed by the European Society Cardiology, Respiratory and International Heart Lung Transplantation (ESC/ERS/ISHLT), may predict long-term survival in patients with SLE.
Polyunsaturated fatty acids (PUFA) contained in fish oil (FO) are ligands for peroxisome proliferator-activated receptors (PPAR) that may induce changes cardiometabolic markers. Variation PPAR genes influence the beneficial responses linked to FO supplementation young adults. The study aimed analyze effect of on glucose metabolism, circulating lipids and inflammation according PPARα L162V PPARγ2 P12A genotypes Mexican 191 young, non-smoking subjects between 18 40 years were included a...
Information about angiotensin II (Ang II), angiotensin-converting enzyme 2 (ACE2), and Ang-(1-7) levels in patients with COVID-19 is scarce.To characterize the Ang II-ACE2-Ang-(1-7) axis SARS-CoV-2 infection to understand its role pathogenesis prognosis.Patients greater than 18 years diagnosed COVID-19, based on clinical findings positive RT-PCR test, who required hospitalization treatment were included. We compared II, aldosterone, Ang-(1-7), Ang-(1-9) concentrations ACE2 concentration...
Background. Chronic renal damage is associated with inflammatory infiltration, fibrosis and vascular lesion, coupled increased expression of cyclo-oxygenase 2 (COX-2) transforming growth factor-β1 (TGF-β1). However, the role inducible nitric oxide synthase (NOS-2) still controversial. Thus, we studied contribution NOS-2 to levels COX-2 TGF-β1, as well structural injury in rats subtotal ablation (5/6 Nx).