A5056280532- Ocular Disorders and Treatments
- Retinal Development and Disorders
- melanin and skin pigmentation
- Ubiquitin and proteasome pathways
- Peroxisome Proliferator-Activated Receptors
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Nuclear Receptors and Signaling
- Cardiovascular Health and Disease Prevention
- Protein Degradation and Inhibitors
- CAR-T cell therapy research
- Blood Pressure and Hypertension Studies
- Fatty Acid Research and Health
University of Edinburgh
2021-2024
MRC Institute of Genetics and Molecular Medicine
2021-2024
Medical Research Council
2021
National Institute of Genomic Medicine
2017
Degron tagging allows proteins of interest to be rapidly degraded, in a reversible and tuneable manner, response chemical stimulus. This provides numerous opportunities for understanding disease mechanisms, modelling therapeutic interventions constructing synthetic gene networks. In recent years, many laboratories have applied degron successfully cultured mammalian cells, spurred by rapid advances the fields genome editing targeted protein degradation. this At Glance article, we focus on...
Polyunsaturated fatty acids (PUFA) contained in fish oil (FO) are ligands for peroxisome proliferator-activated receptors (PPAR) that may induce changes cardiometabolic markers. Variation PPAR genes influence the beneficial responses linked to FO supplementation young adults. The study aimed analyze effect of on glucose metabolism, circulating lipids and inflammation according PPARα L162V PPARγ2 P12A genotypes Mexican 191 young, non-smoking subjects between 18 40 years were included a...
An intervention study conducted in young Mexican adults showed significant improvement of the supplementation with fish oil (FO) on glucose metabolism. Differences response among subjects were observed. Gene expression peripheral blood mononuclear cells (PBMC) has been used as a proxy effect nutritional interventions other tissues. We compared changes transcriptome PBMC induced by FO (2.7 g DHA + EPA during six weeks) contrasting responses fasting insulin concentrations. Participants largest...
Abstract Anophthalmia (missing eye) describes a failure of early embryonic ocular development. Mutations in relatively small set genes account for 75% bilateral anophthalmia cases, yet 25% families currently are left without molecular diagnosis. Here we report our experimental work that aimed to uncover the developmental and genetic basis characterising X-linked Ie (eye-ear reduction) X-ray induced allele mouse was first identified 1947. Histological analysis phenotype showed normal eye...
Anophthalmia (missing eye) describes a failure of early embryonic ocular development. Mutations in relatively small set genes account for 75% bilateral anophthalmia cases, yet 25% families currently are left without molecular diagnosis. Here, we report our experimental work that aimed to uncover the developmental and genetic basis characterising X-linked Ie (eye-ear reduction) X-ray-induced allele mouse was first identified 1947. Histological analysis phenotype showed normal eye development...