A5052457644- Vasculitis and related conditions
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Atherosclerosis and Cardiovascular Diseases
- Congenital Heart Disease Studies
- Systemic Lupus Erythematosus Research
- COVID-19 Clinical Research Studies
- Cardiovascular Function and Risk Factors
- Connective tissue disorders research
- Vitamin C and Antioxidants Research
- Coronary Artery Anomalies
- Cardiac Imaging and Diagnostics
- Viral Infections and Immunology Research
- Infective Endocarditis Diagnosis and Management
- Cynara cardunculus studies
- Hibiscus Plant Research Studies
- MicroRNA in disease regulation
- Aortic aneurysm repair treatments
- Adipose Tissue and Metabolism
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Disease and Adiposity
- Cardiomyopathy and Myosin Studies
- Long-Term Effects of COVID-19
- Cardiovascular Issues in Pregnancy
- Cardiac Structural Anomalies and Repair
Instituto Nacional de Cardiología
2016-2025
Centro Médico ABC
2015-2025
Universidad Nacional Autónoma de México
2003-2025
Instituto Nacional de Cardiologia
2005-2024
Bluefields Indian and Caribbean University
2022
University of Alabama at Birmingham Hospital
2022
El Colegio de México
2011
Universidad Autónoma Metropolitana
2010
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2005
New Century International Hospital for Children
2005
The type 2 coronavirus causes severe acute respiratory syndrome (SARS-CoV-2) and produces pneumonia with pulmonary alveolar collapse. In some cases it also sepsis septic shock. There is no specific treatment for disease 2019 (COVID-19). Vitamin C (Vit C), E E), N-acetylcysteine (NAC) Melatonin (MT) increase the intracellular content of GSH, kidnap free radicals protect DNA, proteins in cytosol lipids cell membranes. Pentoxifylline (Px) has anti-inflammatory activities. Here we evaluate...
Deregulation of micro-RNAs (miRNAs) may contribute to mechanisms injury in the bicuspid aortic valve (BAV). Our objective was investigate expression miRNAs tissue from patients who underwent replacement for stenosis and its relationship with dilatation. The study included 78 patients, 40 (BAV) 38 tricuspid (TAV). miRNA-17-5p, hsa-let-7e, miRNA-196a-5p human evaluated by a reverse transcriptase polymerase chain reaction (RT-qPCR). Comparative analysis between BAV controls TAV explored...
Background and objectives: Oxidative stress (OS) participates in the pathophysiology of septic shock, which leads to multiple organ failure (MOF), ischemia-reperfusion injury, acute respiratory distress syndrome. Therefore, antioxidants have been proposed as therapy. Here, we evaluated effect antioxidant treatments patients with shock MOF determined levels OS before after treatment. This study was a randomized, controlled, triple-masked, parallel assignment clinical trial control group...
The kidnapping of the lipid metabolism host’s cells by severe acute respiratory syndrome (SARS-CoV-2) allows virus to transform into optimal machines for its assembly and replication. Here we evaluated changes in fatty acid (FA) profile participation activity desaturases, plasma patients with pneumonia SARS-CoV-2. We found that SARS-CoV-2 alters FA host. Changes are characterized variations desaturases lead a decrease total (TFA), phospholipids (PL) non-esterified acids (NEFAs). These...
The infection with SARS-CoV-2 impairs the glucose–insulin axis and this contributes to oxidative (OS) nitrosative (NSS) stress. Here, we evaluated changes in glucose metabolism that could promote loss of redox homeostasis COVID-19 patients. This was comparative cohort analytical study compared patients healthy subjects. population consisted 61 without comorbidities 25 subjects (HS). In all plasma glucose, insulin, 8-isoprostane, Vitamin D, H2S 3-nitrotyrosine were determined by ELISA....
Background and aim: Here, we assess the effect of adjuvant antioxidant therapies in septic shock patients with organ dysfunction their on enzymatic non-enzymatic systems. Methods: Randomized clinical trial run between 2018 2022. One hundred thirty-one were included five groups 25, 27, 24, 26 29 each. Group 1 received vitamin C (Vit C), 2 E E), 3 n-acetylcysteine (NAC), 4 melatonin (MT) group 5 no treatment. All antioxidants administered orally or through a nasogastric tube for days as an to...
Abstract Background Takayasu’s arteritis (TA) is a chronic inflammatory disease affecting the large arteries and their branches; its etiology still unknown. In individuals suffering from TA, arterial inflammation progresses to stenosis and/or occlusion, leading organ damage survival. Relation of TA with Mycobacterium tuberculosis has been known, but there have only few systematic studies focusing on this association. The IS6110 sequence identifies complex HupB establishes differences between...
of chromosomal abnormality, therefore the diagnosis requires a karyotype determination. 4)he prevalence congenital heart disease (CHD) in DS is approximately 43%. 5) The most common cardiac malformations associated with include atrioventricular canal, patent ductus arteriosus and atrial septal defect (ASD) ventricular (VSD).6) Some conditions have intra extra-cardiac shunts that can lead to pulmo-
Type II pneumocytes are the target of SARS-CoV-2 virus, which alters their redox homeostasis to increase reactive oxygen species (ROS). Melatonin (MT) has antioxidant proprieties and protects mitochondrial function. In this study, we evaluated whether treatment with MT compensated for alteration in serum from COVID-19 patients. We determined oxidative stress (OS) markers such as carbonyls, glutathione (GSH), total capacity (TAC), thiols, nitrites (NO2-), lipid peroxidation (LPO), thiol...
Beals-Hecht (BH) syndrome is a rare autosomal dominant disorder caused by mutation of the FBN2 gene that codifies for fibrillin-2 (FBN-2) and part its nosology congenital contractural arachnodactyly. There no information in literature on whether there increased oxidative stress (OS) these patients could lead to break-down redox balance. Therefore, aim this preliminary study was evaluate possible breakdown homeostasis thoracic aortic aneurysm (TAA) BH. We determinate OS markers such as...
Introduction: Marfan syndrome (MFS) is an autosomal dominant genetic disorder, caused by a mutation in the FBN-1 gene, affecting cardiovascular, musculoskeletal, ocular, and central nervous systems. Cardiovascular abnormalities associated with MFS lead to different pathological conditions, such as cardiac arrhythmias, coronary artery disease, aortic dilatation. The latter are primary causes of mortality patients. To date, role altered oral microbiota (OM) unknown, so aim our study was...
Beals-Hecht (BH) syndrome is a rare autosomal dominant disorder caused by mutation of the FBN-2 gene that codifies for fibrillin-2 (FBN-2) and its nosology includes congenital contractural arachnodactyly. There no information in literature on whether there increased oxidative stress (OS) these patients could lead to break-down redox balance. Therefore, aim this study was evaluate possible breakdown homeostasis thoracic aortic aneurysm (TAA) BH. We determinate OS markers such as...
Background Type 4 cardiorenal syndrome (CRS) involves cardiovascular alterations caused by chronic kidney disease (CKD). Fibroblast growth factor-23 (FGF23), carboxy-terminal propeptide of procollagen type I (PIP), and parathyroid hormone (PTH) have been proposed as biomarkers pathological cardiac remodeling in CKD. In contrast, it has suggested that MicroRNA 221 a cardioprotective role. Available evidence shows that, 12 months after transplantation (KT), CRS reverts only half the patients....