A5087171610- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Genetic Associations and Epidemiology
- Fish Ecology and Management Studies
- Fish biology, ecology, and behavior
- Malaria Research and Control
- Agricultural and Food Production Studies
- Vector-borne infectious diseases
- Machine Learning in Bioinformatics
- Forensic and Genetic Research
- Aging, Health, and Disability
- Viral Infections and Outbreaks Research
- Fish Biology and Ecology Studies
- Genetic and phenotypic traits in livestock
- History and Politics in Latin America
- Zoonotic diseases and public health
- Genetic diversity and population structure
- Bioinformatics and Genomic Networks
- Salmonella and Campylobacter epidemiology
- Indigenous Studies and Ecology
- Escherichia coli research studies
- Neurotransmitter Receptor Influence on Behavior
- Gut microbiota and health
- Alzheimer's disease research and treatments
- Hippo pathway signaling and YAP/TAZ
Universidad de Antioquia
2010-2025
Universidad Nacional de Colombia
2024
Chronic Disease Prevention Alliance of Canada
2023
Universidad de Los Andes
2011
Colombia is a country with great geographic heterogeneity and marked regional differences in pre-Columbian native population density the extent of past African European immigration. As result, has one most diverse populations Latin America. Here we evaluated ancestry over 1,700 individuals from 24 Colombian using biparental (autosomal X-Chromosome), maternal (mtDNA), paternal (Y-chromosome) markers. Autosomal varies markedly both within between regions, confirming genetic diversity...
Progress in the acquisition of massive sets molecular data and bioinformatic capabilities for their processing have revolutionised species identification, filling gaps crucial areas such as taxonomy, phylogenetic inference, biogeography, even biodiversity conservation. Advanced DNA sequencing metabarcoding uncovered previously hidden diversity, although effectiveness is highly dependent on accuracy reference databases at local regional scales. The compilation information freshwater fishes...
To identify and characterize high-order gene-to-gene interactions in antisocial personality disorder (ASPD).Participants for case-control study were selected from the inmate male population Bellavista prison Medellin. The included 310 individuals with ASPD 200 no ASPD. Diagnoses made according to a best-estimate procedure based on semistructured interview (diagnostic genetic studies 3.0). We genotyped some single-nucleotide polymorphisms candidate genes main serotonin pathway effects....
Alzheimer's disease (AD) is the most common cause of dementia in elderly, affecting over 50 million people worldwide 2020 and this number will triple to 152 by 2050. Much increase be developing countries like Colombia. In familial forms, highly penetrant mutations have been identified three genes, APP, PSEN1, PSEN2, supporting a role for amyloid-β peptide. sporadic more than 30 risk genes involved lipid metabolism, immune system, synaptic functioning mechanisms. We used whole-exome...
Abstract Astyanax caucanus is an endemic fish species to the Magdalena-Cauca basin in Colombia. It considered a Least Concern by International Union for Conservation of Nature, and currently, it not fishery resource. Its fertilized eggs may drift up 4–5 days before hatching can be carried 340 km given water velocity river. Although A. listed as short -migratory (< 50 km), this study hypothesized that exhibits gene flow along middle lower section Cauca River due great potential larval...
Identifying the genetic and non-genetic determinants of obesity related cardiometabolic dysfunctions is cornerstone for their prevention, treatment, control. While variants contribute to syndrome (CMS), factors, such as gut microbiota, also play key roles. Gut microbiota intimately associated with CMS its composition heritable. However, associations between this microbial community host genetics are understudied. We filling gap by genotyping 60 in 39 genes three modules involved risk,...
Host genetics is recognized as an influential factor for the development of dengue disease.This study evaluated association with polymorphisms rs8192284 gene IL6R, rs3775290 TLR3, and rs7248637 DC-SIGN.Of 292 surveyed subjects, 191 were confirmed fever remaining 101 included controls. The genotypes resolved using polymerase chain reaction restriction fragment length polymorphism (PCRRFLP). In attempt to determine risk (Odds Ratio) suffering fever, data analyzed chi-square alleles logistic...
Spawning sites play a key role in the reproduction of fish allowing populations to endure over time. The Nechí River is an important spawning area for potamodromous species where one threats dam construction. In order determine importance as site Magdalena basin, sampling was conducted during low-water-to-high-water season transition period between 2018 and 2019 at seven sites. average density ichthyoplankton 42.4 ind.10m-3 (SD = 7.1). Of individuals post-larval stage, migratory were...
Etiologic studies provide evidence that IL-4R and IL-6R receptors may play important roles in the regulatory mechanisms of development clinical dengue, especially children which is a segment population with high severe dengue risk. Moreover, allele frequencies genetic associations be influenced by populational background. Therefore, we performed case-control study to evaluate possible between SNPs IL4R IL6R genes from two Colombian populations.We genotyped rs1805016 (IL4R) rs8192284 (IL6R)...
Introducción. La composición genética del huésped determina, entre otros aspectos, el perfil clínico dengue, lo cual se debería al efecto de variantes en los genes que codifican citocinas proinflamatorias.Objetivo. Evaluar la asociación las tres polimorfismos candidatos TNFA, IL6 e IFNG con gravedad dengue una población colombiana.Materiales y métodos. Se evaluaron rs1800750, rs2069843 rs2069705 IFNG, respectivamente, 226 pacientes dengue. Los genotipos tipificaron usando reacción cadena...
Introduction: Aedes aegypti populations may experience changes in abundance and genetic diversity addition to their evolutionary capability respond vector control. The knowledge on the variation a spatio-temporal scale improves epidemiological understanding of dengue supports appropriate timely design control strategies.Objective: To assess changes, gene flow six microgeographical Ae. Medellín for different periods dengue.Materials methods: A total 255 specimens from neighborhoods were used...
Functional immunological evidence supports the impact that host genetic variability has on susceptibility to develop asymptomatic or symptomatic dengue infection. Children are more prone severe dengue. Thus, we have evaluated possible associations between single-nucleotide polymorphisms (SNPs) located in immune genes and development of children from two Colombian populations with differences backgrounds geographical features. We genotyped 15 SNPs (in 12 genes) 298 648 healthy controls....
Por medio del análisis de marcadores genéticos cromosoma Y, se estudió la composición los linajes y su distribución en apellidos más comunes una muestra 471 hombres provenientes municipio Marinilla (Antioquia) zona influencia Aranzazu (Caldas), un grupo muestras población general Medellín. Además encontrar tasa variable coancestría entre también detectó gran similitud el patrón haplogrupos/haplotipos/apellidos Aranzazu, hallazgo que refuerza idea migración histórica estas dos regiones. Esta...
L’objectif de cet addenda et note l’éditeur est fournir plus d’information d’éléments context jugés pertinents pour les lectrices lecteurs en lien avec l’article suivant : Yakubovich AR, Steele B, Moses C, Tremblay E, Arcenal M, O’Campo P, Mason R, Du Mont J, Huijbregts Hough L, Sim A, Shastri P. Recommandations le Plan d’action national mettre fin à la violence fondée sur genre points vue dirigeants, fournisseurs services survivantes dans grande ville du Canada pendant pandémie COVID-19....
Avian pathogenic E. coli (APEC), produces an extraintestinal infection in chickens, turkeys, and other types of birds, called colibacillosis, which is considered one the main causes economic losses due to morbidity, mortality, discard poultry carcasses. The objective present study was characterize genetic profile virulence factors different isolates avian Caloto, Cauca, Colombia. Materials methods: isolated identified by biochemical tests, from 47 clinical isolates. Subsequently, DNA...
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Introducción: Las placas amiloides son uno de los marcadores neuropatológicos la enfermedad Alzheimer, formadas por fragmentos peptídicos que se depositan, derivados del corte proteasa enzima γ-secretasa, cual presenilina-1 es subunidad con el sitio activo, posible investigar a nivel evolutivo sucede esta proteína en una muestra homínidos. Materiales y métodos: hace un estudio biología estructural para evaluar cambios estructura las proteínas modeladas software Phyre2 alineamientos secuencia...