A5088939081- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Drug-Induced Hepatotoxicity and Protection
- Global Maternal and Child Health
- Parasite Biology and Host Interactions
- Biosensors and Analytical Detection
- Digital Imaging for Blood Diseases
- Vitamin D Research Studies
- Venomous Animal Envenomation and Studies
- Parasitic Infections and Diagnostics
- Computational Drug Discovery Methods
- Vector-borne infectious diseases
- Diverse Scientific Research Studies
- Complement system in diseases
- Vitamin C and Antioxidants Research
- Research on Leishmaniasis Studies
- Mycobacterium research and diagnosis
- Viral Infections and Vectors
- Neonatal Health and Biochemistry
- Viral gastroenteritis research and epidemiology
- Tuberculosis Research and Epidemiology
- Synthesis and bioactivity of alkaloids
University of Gondar
2014-2025
University of Guam
2017
Wolaita Sodo University
2015
University of Calgary
2015
Treatment of Plasmodium vivax malaria requires the clearing asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from liver (a treatment termed "radical cure"). Tafenoquine is a single-dose 8-aminoquinoline that has recently been registered for radical cure P. vivax.
Malaria is a major public health problem in sub-Saharan African countries including Ethiopia. Early and accurate diagnosis followed by prompt effective treatment among the various tools available for prevention, control elimination of malaria. This study aimed to evaluate performance non-instrumented nucleic acid amplification loop-mediated isothermal (NINA-LAMP) compared standard thick thin film microscopy nested PCR as gold sensitive malaria Northwest Ethiopia.A cross-sectional was...
In Ethiopia, urinary schistosomiasis caused by Schistosoma haematobium has been known to be endemic in several lowland areas of the country where it causes considerable public health problems, mainly among school-age children. However, information on recent magnitude and risk factors disease is lacking, particularly for Gambella area. Therefore, this study aimed assess prevalence associated Abobo Primary School children Gambella, southwestern Ethiopia.A cross-sectional involving 304 school...
Artemisinin combination therapy (ACT) is the first line to treat uncomplicated Plasmodium falciparum malaria worldwide. treatment failures are on rise in southeast Asia. Delayed parasite clearance after ACT associated with mutations of P. kelch 13 gene. Patients ( N = 148) five districts northwest Ethiopia were enrolled a 28-day trial. We identified unique mutation (R622I) 3/125 (2.4%) samples. The three isolates R622I from Negade-Bahir and Aykel close Ethiopia–Sudan border. One patients...
Introduction . Asymptomatic malaria is prevalent in highly endemic areas of Africa and new challenge for prevention control strategies. Objective To determine the prevalence asymptomatic associated risk factors among school children Sanja Town, northwest Ethiopia. Methods. A cross-sectional study was conducted from February to March 2013, on 385 selected using stratified proportionate systematic sampling technique. Pretested questionnaire used collect sociodemographic data factors....
Malaria remains one of the leading communicable diseases in Ethiopia. Early diagnosis combined with prompt treatment is main strategies for malaria prevention and control. Despite its limitation, Giemsa microscopy still considered to be gold standard diagnosis. This study aimed compare performance nested polymerase chain reaction (nPCR) north-west Ethiopia.A cross sectional was conducted public health facilities North Gondar, from March 2013 April 2013. A total number 297 subjects suspected...
Malaria is a major public health problem and an important cause of maternal infant morbidity in sub-Saharan Africa, including Ethiopia. Early accurate diagnosis malaria with effective treatment the best strategy for prevention control complications during pregnancy mortality. However, laboratory has relied on identification parasites parasite antigens peripheral blood using Giemsa-stained microscopy or rapid diagnostic tests (RDTs) which lack analytical clinical sensitivity. The aim this...
Abstract Background Malaria elimination requires diagnostic methods able to detect parasite levels well below what is currently possible with microscopy and rapid tests. This particularly true in surveillance of malaria at the population level that includes so-called “asymptomatic” individuals. Methods The development first ultrasensitive loop mediated amplification method capable detecting from both whole blood dried spots (DBS) described. 18S rRNA corresponding genes remain stable on DBS...
Abstract According to the WHO, almost two thirds of Ethiopian population are at risk contracting malaria, where infection with Plasmodium falciparum accounts for approximately 60% cases today. The artemisinin resistance spreading from southeast Asia Africa is a major concern. We conducted 28-day in vivo efficacy trial Artemether-Lumefantrine (Co-Artem) treatment uncomplicated malaria (n = 97) Gondar area, northwest Ethiopia 2017–2018. Our results confirmed 100% adequate clinical and...
In Ethiopia, where malaria and schistosomiasis are co-endemic, co-infections expected to be high. However, data about the prevalence of malaria-schistosomiasis co-infection their clinical correlation is lacking. Therefore, aim this study was assess Schistosoma mansoni associated correlates in patients. A cross-sectional conducted 2013 at Chwahit Health Center, northwest Ethiopia. Blood film positive patients (N = 205) were recruited for study. Clinical, parasitological, hematological,...
Plasmodium falciparum accounts for approximately 60% of malaria cases in Ethiopia and artemether-lumefantrine has been used as a first-line treatment uncomplicated P. since 2004. The aim this study was to assess the therapeutic efficacy (AL) north-western Ethiopia.A 28-day one-arm, prospective evaluation clinical parasitological response conducted Enfranze Health Centre accordance with 2009 WHO guidelines. Patients were treated 3-day course AL parameters monitored over follow-up. All data...
Recent studies suggest that the incidence and severity of tuberculosis is associated with low levels vitamin D. Even though individuals living in Ethiopia have a high exposure to sunlight which source D, still one major causes morbidity mortality country. Therefore, this study aimed determine prevalence factors D deficiency newly diagnosed patients, household contacts community controls Gondar, Ethiopia. A comparative cross-sectional design was conducted. Blood samples were collected from...
Background . Despite high prevalence of visceral leishmaniasis and malaria in the study area, their coinfection remains unknown. Therefore, this was aimed to document VL-malaria coinfections associated factors. Methods A cross-sectional conducted among clinical suspected VL patients attending Metema hospital, Northwest Ethiopia, from January 2014 June 2014. Blood sample tested by rk39 antigen-based DiaMed IT-Leish dipstick Giemsa stain microscopic examination thick thin blood smears for...
Infectious diarrhea is a common problem in the developing world, especially among people living with HIV/AIDS. Traditional diagnostic methods such as stool culture and microscopic examination are limited by resources poor sensitivity. The use of molecular diagnostics for enteropathogen detection this region sub-Saharan Africa has not been fully explored. We sought to identify risk factors characterize enteropathogens from diarrheic stools HIV-positive patients Gondar, Ethiopia using...
Abstract According to the WHO, almost two thirds of Ethiopian population are at risk contracting malaria, where infection with Plasmodium falciparum accounts for approximately 60% cases today. The artemisinin resistance spreading from SE Asia Africa is a major concern. We conducted 28-day in vivo efficacy trial Artemether-Lumefantrine (Co-Artem) treatment uncomplicated malaria (n = 97) Gondar Region, North West Ethiopia 2017–2018. Our results confirmed 100% adequate clinical and...
To assess the performance of RDTs against nested polymerase chain reaction (nPCR) for diagnosis malaria in public health facilities north-western Ethiopia.Cross-sectional study at North Gondar, Ethiopia, 359 febrile patients with signs and symptoms consistent malaria. Finger prick blood samples were collected testing a P. falciparum/pan-malaria molecular analysis. Sensitivity, specificity predictive values determined using nPCR as reference diagnostic method. Kappa value was to demonstrate...
Although the overall burden of malaria is decreasing in Ethiopia, a recent report an unpredictable increased incidence may be related to presence community-wide gametocyte-carrier individuals and high proportion infected vectors. This study aimed reveal current prevalence gametocyte-carriage sporozoite infectivity rate Anopheles vectors for Plasmodium parasites. A community-based cross-sectional was conducted from May 01 June 30/2019. total 53 households were selected using systematic random...
Rapid diagnostic tests (RDTs) targeting
<title>Abstract</title> <bold>Background</bold> Malaria in children remains a major public health problem the global, especially sub-Saharan Africa. WHO reported an annually declining burden of malaria Ethiopia. Despite these, different parts country contradictory result, and to be main cause morbidity among children. However, Microscopic examination peripheral blood smear produces reliable results. Therefore, aim this study was compare performance microscopy nested polymerase chain reaction...
Background: Asymptomatic malaria poses a huge challenge in meeting the malaria, elimination goal. Due to poor sensitivity of common laboratory diagnostic methods like rapid diagnosis tests (RDTs) and Giemsa stained microscopy, it has often been difficult detect asymptomatic malaria. Thus, highly sensitive, specific, field deployable molecular techniques need be available accurately disease. This study aimed assess application preventive prevalence using traditional microscopy methods, such...