A5075439007- Malaria Research and Control
- Healthcare Regulation
- Public Health in Brazil
- Mosquito-borne diseases and control
- Hemoglobinopathies and Related Disorders
- Neonatal Health and Biochemistry
- Science and Education Research
- Healthcare during COVID-19 Pandemic
- Blood groups and transfusion
- HIV/AIDS Research and Interventions
- Antibiotic Use and Resistance
- Women's cancer prevention and management
- Pharmacogenetics and Drug Metabolism
- Vector-borne infectious diseases
- Drug-Induced Hepatotoxicity and Protection
- Maternal and Neonatal Healthcare
- Youth, Drugs, and Violence
- Drug Transport and Resistance Mechanisms
- Methemoglobinemia and Tumor Lysis Syndrome
- Metabolism and Genetic Disorders
- Papaya Research and Applications
- Medical Malpractice and Liability Issues
- Academic Research in Diverse Fields
- Education during COVID-19 pandemic
- Pharmacology and Obesity Treatment
Fundação de Medicina Tropical
2016-2025
Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas
2025
Universidade do Estado do Amazonas
2016-2024
Faculdade Metropolitana de Manaus
2020-2023
Centro Universitário do Rio Grande do Norte
2021-2023
Universidade Federal do Amazonas
2020-2023
Fundação de Amparo à Pesquisa do Estado do Amazonas
2023
Universidade Federal de Goiás
2023
Universidade de São Paulo
2023
Protéomique, Réponse Inflammatoire et Spectrométrie de Masse
2023
Population-based studies conducted in Latin America have shown a high proportion of asymptomatic and submicroscopic malarial infections. Considering efforts aiming at regional elimination, it is important to investigate the role this reservoir malaria transmission peri-urban areas. This study aimed estimate prevalence Plasmodium spp. gametocyte burden on symptomatic infections Brazilian Amazon. Two cross-sectional household surveys (CS) were including all inhabitants area Manaus, western...
Abstract Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) therefore major components of plasma holding insights into pathological processes. Here, we demonstrate plasma-derived EVs from patients ( Pv EVs) preferentially uptaken by spleen fibroblasts h SFs) as compared to uptake healthy individuals. Moreover, this...
Plasmodium vivax is the most widely distributed human malaria parasite and responsible for large amounts of disease burden [1].The presence P. in bone marrow was first noticed late 19th century [2], examinations sternal aspirates were performed as an accessory to peripheral blood malaria, including [3].Since then, little progress has been made studying infections this tissue.One report explored accumulation dyserythropoietic cells anaemic infected patients [4].In addition, two case studies...
CYP2D6 pathway mediates the activation of primaquine into active metabolite(s) in hepatocytes. is highly polymorphic, encoding isoforms with normal, reduced, null or increased activity. It hypothesized that Plasmodium vivax malaria patients defective function would be at risk for failure to prevent recurrence. The aim this study was investigate association polymorphisms and inferred phenotypes recurrence from Western Brazilian Amazon, following chloroquine/primaquine combined therapy....
Abstract Background Daily primaquine-induced hemolysis is a common cause of complications during Plasmodium vivax malaria treatment in individuals with glucose 6-phosphate dehydrogenase deficiency (G6PDd). Alternative regimens balancing safety and efficacy are needed. Methods G6PDd participants P. from two sites Brazilian Amazon between 2018 2022 were randomly allocated to three study arms, which received chloroquine (CQ) day 1 3 plus: (arm-1) seven-day course primaquine (PQ) (0.5mg/kg/day),...
The resistance of Plasmodium vivax to chloroquine has become an obstacle control strategies based on the use anti-malarials. current study investigated association between P. CQ-resistance in vivo with copy number variation and mutations promoter region pvcrt-o pvmdr1 genes. included patients that received supervised treatment primaquine. Recurrences were actively recorded during this period. Among 60 vivax, 25 CQ-resistant 35 CQ-susceptible. A frequency 7.1% multi-copy was observed...
The presence of Plasmodium vivax malaria parasites in the human bone marrow (BM) is still controversial. However, recent data from a clinical case and experimental infections splenectomized nonhuman primates unequivocally demonstrated this tissue.In current study, we analyzed BM aspirates 7 patients during acute attack 42 days after drug treatment. RNA extracted CD71+ cell suspensions was used for sequencing transcriptomic analysis.We all infections. To provide further insights, purified...
Asymptomatic individuals are one of the major challenges for malaria elimination programs in endemic areas. In absence clinical symptoms and with a lower parasite density they constitute silent reservoirs considered important maintaining transmission human malaria. Studies from Brazil have shown that infected may carry these parasites long periods. Patients were selected three periurban areas city Manaus, western Brazilian Amazon. Symptomatic asymptomatic patients positive thick blood smear...
In Latin America, where Plasmodium vivax malaria is more prevalent, it known that this species plays an important role in the sustainability of transmission, and can have impact on morbidity terms anaemia, nutritional status, cognitive development children. The present study aimed to assess infection cognition children a peri-urban community Brazilian Amazon with moderate endemicity by applying Home Inventory WPPSI-IV. A non-concurrent cohort was designed cognitive, haematological, profiles...
In the Brazilian Amazon, malaria infections are primarily caused by Plasmodium vivax. The only drug that kills hypnozoite form of P. vivax is primaquine, thereby preventing relapse. However, treating glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals with primaquine can lead to severe hemolysis. G6PD deficiency (G6PDd) affects approximately 400 million people worldwide, most whom live in malaria-endemic areas. Therefore, clinicians need tools easily and reliably identify G6PDd....
Background Understanding epidemiological variables affecting gametocyte carriage and density is essential to design interventions that most effectively reduce malaria human-to-mosquito transmission. Methodology/Principal findings Plasmodium falciparum P . vivax parasites gametocytes were quantified by qPCR RT-qPCR assays using the same methodologies in 5 cross-sectional surveys involving 16,493 individuals Brazil, Thailand, Papua New Guinea, Solomon Islands. The proportion of infections with...
Difficulties associated with the assessment of glucose-6-phosphate dehydrogenase deficiency (G6PDd), particularly in remote areas, hinders safe use 8-aminoquinolines such as primaquine (PQ) and tafenoquine against Plasmodium vivax malaria due to risk haemolysis.This cross-sectional study was conducted 41 malaria-endemic municipalities six states Brazilian Amazon, between 2014 2018. Male individuals were screened for G6PDd using qualitative Fluorescent Spot Test fingerpick-collected whole...
Background Plasmodium vivax malaria (Pv-malaria) is still considered a neglected disease despite an alarming number of individuals being infected annually. Malaria pathogenesis occurs with the onset vector-parasite-host interaction through binding pathogen-associated molecular patterns (PAMPs) and receptors innate immunity, such as toll-like (TLRs). The triggering signaling cascade produces elevated inflammatory response. Genetic polymorphisms in TLRs are involved susceptibility or...
Malaria can be transmitted by blood transfusion through donations collected from asymptomatic donors. Transfusion-transmitted malaria (TTM) poses a great risk to services worldwide. A good screening tool for Plasmodium spp. detection in banks must have high sensitivity prevention of TTM. However, Brazilian banks, still relies on microscopy.In Brazil, human immunodeficiency virus type 1 (HIV), RNA/DNA hepatitis C (HCV) and B (HBV) viruses is mandatory every donation uses nucleic acid...
Abstract Malaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as promising tool combating disease. The study evaluated plasma metabolomic profiles of patients recurrent and non-recurrent malaria in Brazilian Amazon. Metabolites extracted from -infected were subjected to LC–MS analysis. Untargeted was applied investigate metabolic profile two groups. Overall, 51 59 included study. Longitudinal...
INTRODUÇÃO: A automedicação exibe potencial de risco nas interações medicamentosas, reações adversas, toxicidade, provocando um diagnóstico incorreto ou tardio, devido ao fármaco mascarar a patologia, resultando em uma resistência micro-organismo não resolução no quadro clínico dos pacientes.OBJETIVO: Objetivo do estudo é verificar quais os medicamentos mais utilizados na e analisar fatores que levam automedicação.MÉTODOS: Os estudos foram pesquisados seguintes bases dados: Scielo...
To investigate the impact of Plasmodium vivax malaria and chloroquine-primaquine chemotherapy on CYP2D6 CYP2C19 activity in patients from Brazilian Amazon.Adult (n = 30) were given subtherapeutic doses phenotypic probes metoprolol (10 mg) omeprazole (2 three different stages illness: acute disease (study phase 1), post (phase 2) convalescence (stage 3). Plasma concentrations CYP-hydroxylated metabolites (α-OH 5-OH omeprazole) measured using LC/MS/MS. Two pharmacokinetic metrics used to...
Understanding the epidemiology of malaria through molecular force blood-stage infection Plasmodium vivax (molFOB) may provide a detailed assessment transmission.In this study, we investigated risk factors and spatial-temporal patterns incidence clinical episodes in three peri-urban communities Manaus, Western Brazilian Amazon.Monthly samples were collected cohort 1,274 individuals between April 2013 March 2014. DNA subject to species. molFOB was calculated by counting number genotypes...
Vector-borne diseases account for more than 17% of all infectious diseases, causing one million deaths annually. Malaria remains the most important public health problems worldwide. These vectors are bloodsucking insects, which can transmit disease-producing microorganisms during a blood meal. The contact culicids with human populations living in malaria-endemic areas suggests that identification Plasmodium genetic material present gut these mosquitoes may be possible. process assessing meal...
Introdução: O câncer de colo útero (CCU) é um tipo neoplasia maligna causada pelos HPVs (papilomavírus humano). Diante da problemática do CCU e alta endemicidade na região Norte Brasil, importante uma melhor compreensão dados epidemiológicos recentes desta população referida região. Objetivos: Avaliar a frequência, tratamento estadiamento dos casos norte Brasil nos anos 2017 2021. Metodologia: Trata-se estudo epidemiológico descritivo. Foram incluídos nas análises os indivíduos com...
Introdução: A alta busca para perda de peso a curto prazo acarreta o uso indevido medicamentos emagrecimento sem acompanhamento um profissional da saúde, podendo causar dependência física, intoxicação e efeitos colaterais graves. Objetivo: Apresentar as formas intervenção do farmacêutico no dos emagrecer. Metodologia: Trata-se uma revisão sistemática seguindo os critérios Prisma, utilizando base dados das bibliotecas virtuais online BVS, Scielo Pubmed. Os inclusão são: publicações artigos...
The novel coronavirus disease 2019 (COVID-19) presents with complex pathophysiological effects in various organ systems. Following the COVID-19, there are shifts biomarker and cytokine equilibrium associated altered physiological processes arising from viral damage or aggressive immunological response. We hypothesized that high daily dose methylprednisolone improved injury biomarkers serum profiles COVID-19 patients. Injury analysis was performed on 50 SARS-Cov-2 negative controls 101...
Toll-interacting protein is a negative regulator in the TLR signaling cascade, particularly by impeding TLR2 and, TLR4 pathway. Recently, TOLLIP was shown to regulate human pathways. Two common polymorphisms (rs5743899 and rs3750920) were reported be influencing IL-6, TNF IL-10 expression. In this study, variants investigated their relation Plasmodium vivax malaria Brazilian Amazon. This cohort study performed municipalities of Careiro Manaus, Western A total 319 patients with P. 263 healthy...
1 Graduação em Farmácia. Centro Universitário Fametro. Manaus, Brasil. 2 Professora Orientadora do Curso de Bacharelado Introdução: Epilepsia é uma disfunção cerebral caracterizada pela ocorrência periódica e imprevisível crises convulsivas, as quais são modificações temporárias comportamento causadas atividade neuronal anormal, desordenada, sincrônica rítmica. O Canabidiol atua forma anticonvulsivante através três mecanismos: neuro protetores, modulação estresse, ou ainda balanço...