A5040485184- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Biochemical and Molecular Research
- Extracellular vesicles in disease
- Complement system in diseases
- Peroxisome Proliferator-Activated Receptors
- Lysosomal Storage Disorders Research
- Malaria Research and Control
- Toxoplasma gondii Research Studies
- Signaling Pathways in Disease
- Parasites and Host Interactions
- Autophagy in Disease and Therapy
- Lipid metabolism and biosynthesis
- Mosquito-borne diseases and control
- Parasitic Infections and Diagnostics
- Cassava research and cyanide
- Sex and Gender in Healthcare
- Neuroinflammation and Neurodegeneration Mechanisms
- Diversity and Career in Medicine
- Ion channel regulation and function
- Proteoglycans and glycosaminoglycans research
- Pregnancy and preeclampsia studies
- Synthesis and Biological Evaluation
- COVID-19 Clinical Research Studies
- Gender Diversity and Inequality
Barcelona Institute for Global Health
2018-2024
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2018-2024
University of Alberta
2022-2024
Universitat de Barcelona
2018-2024
Université Sainte-Anne
2024
McGill University
2024
Universidade Federal de Minas Gerais
2015-2021
Universidad de Los Andes
2014
University of the Andes
2007-2014
UCLouvain
2011-2013
Glycolysis and glyconeogenesis play crucial roles in the ATP supply synthesis of glycoconjugates, important for viability virulence, respectively, human-pathogenic stages Trypanosoma brucei, cruzi, Leishmania spp. These pathways are, therefore, candidate targets antiparasite drugs. The glycolytic/gluconeogenic enzyme enolase is generally highly conserved, with similar overall fold identical catalytic residues all organisms. Nonetheless, potentially differences exist between trypanosomatid...
Abstract Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) therefore major components of plasma holding insights into pathological processes. Here, we demonstrate plasma-derived EVs from patients ( Pv EVs) preferentially uptaken by spleen fibroblasts h SFs) as compared to uptake healthy individuals. Moreover, this...
Abstract Parasites are responsible for the most neglected tropical diseases, affecting over a billion people worldwide (WHO, 2015) and accounting billions of cases year several millions deaths. Research on extracellular vesicles (EVs) has increased in recent years demonstrated that EVs shed by pathogenic parasites interact with host cells playing an important role parasite's survival, such as facilitation infection, immunomodulation, parasite adaptation to environment transfer drug...
Background Glycosomes are a specialized form of peroxisomes (microbodies) present in unicellular eukaryotes that belong to the Kinetoplastea order, such as Trypanosoma and Leishmania species, parasitic protists causing severe diseases livestock humans subtropical tropical countries. The organelles harbour most enzymes glycolytic pathway is responsible for substrate-level ATP production cell. Glycolysis essential bloodstream-form brucei comprising this have been validated drug targets....
Exosomes are extracellular vesicles of endocytic origin containing molecular signatures implying the cell origin; thus, they offer a unique opportunity to discover biomarkers disease. Plasmodium vivax, responsible for more than half all malaria cases outside Africa, is major obstacle in goal elimination due presence dormant liver stages (hypnozoites), which after initial infection may reactivate cause Hypnozoite asymptomatic and there currently no diagnostic tools detect their presence. The...
In Trypanosoma cruzi, the causal agent of Chagas disease, first seven steps glycolysis are compartmentalized in glycosomes, which authentic but specialized peroxisomes. Besides glycolysis, activity enzymes other metabolic processes have been reported to be present such as β-oxidation fatty acids, purine salvage, pentose-phosphate pathway, gluconeogenesis and biosynthesis ether-lipids, isoprenoids, sterols pyrimidines. this study, we purified glycosomes from T. cruzi epimastigotes, collected...
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in controlling several aspects of immune responses, including the activation and differentiation specific T cell subsets antigen-presenting cells, thought to be relevant context experimental Trypanosoma cruzi infection. relevance AhR for outcome T. infection not known was investigated here. We infected wild-type (WT) mice knockout (AhR KO) with (Y strain) determined levels parasitemia, myocardial...
Plasmodium vivax is the most widely distributed human malaria parasite with 7 million annual clinical cases and 2.5 billion people living under risk of infection. There an urgent need to discover new antigens for vaccination as only two vaccine candidates are currently in trials. Extracellular vesicles (EVs) small membrane-bound involved intercellular communication initially described reticulocytes, host cell P. , a selective disposal mechanism transferrin receptor (CD71) maturation...
Hydrogenosomes and mitosomes represent remarkable mitochondrial adaptations in the anaerobic parasitic protists such as Trichomonas vaginalis Giardia intestinalis, respectively. In order to provide a tool study these organelles live cells, HaloTag was fused G. intestinalis IscU T. frataxin expressed hydrogenosomes, The incubation of parasites with fluorescent Halo-ligand resulted highly specific organellar labeling, allowing imaging organelles. With array available ligands technology offers...
Latent liver stages termed hypnozoites cause relapsing Plasmodium vivax malaria infection and represent a major obstacle in the goal of elimination. Hypnozoites are clinically undetectable, presently, there no biomarkers this persistent parasite reservoir human liver. Here, we have identified proteins associated with extracellular vesicles (EVs) secreted from vivo infections exclusively containing hypnozoites. We used P. vivax-infected liver-chimeric (huHEP) FRG KO mice treated...
The spleen is a secondary lymphoid organ with multiple functions including the removal of senescent red blood cells and coordination immune responses against blood-borne pathogens, such as malaria parasites. Despite major role spleen, study its function in humans limited by ethical implications to access human tissues. Here, we employed multiparameter flow cytometry combined cell purification techniques determine populations from transplantation donors. Spleen immuno-phenotyping showed that...