A5084806493- Trypanosoma species research and implications
- Biochemical and Molecular Research
- Research on Leishmaniasis Studies
- Lysosomal Storage Disorders Research
- Parasitic Infections and Diagnostics
- Parasite Biology and Host Interactions
- Parasites and Host Interactions
- Mitochondrial Function and Pathology
- Diet, Metabolism, and Disease
- Enzyme Structure and Function
- Microtubule and mitosis dynamics
- Signaling Pathways in Disease
- Psidium guajava Extracts and Applications
- Transgenic Plants and Applications
- Studies on Chitinases and Chitosanases
- Insect symbiosis and bacterial influences
- Hibiscus Plant Research Studies
- Amoebic Infections and Treatments
- Peroxisome Proliferator-Activated Receptors
- Extracellular vesicles in disease
- Brucella: diagnosis, epidemiology, treatment
- Invertebrate Immune Response Mechanisms
- Calcium signaling and nucleotide metabolism
- Viral Infectious Diseases and Gene Expression in Insects
- Metabolism and Genetic Disorders
University of the Andes
2014-2025
Universidad de Los Andes
2001-2015
University of Edinburgh
2014
Universidad de Los Andes
2006-2012
Glycolysis and glyconeogenesis play crucial roles in the ATP supply synthesis of glycoconjugates, important for viability virulence, respectively, human-pathogenic stages Trypanosoma brucei, cruzi, Leishmania spp. These pathways are, therefore, candidate targets antiparasite drugs. The glycolytic/gluconeogenic enzyme enolase is generally highly conserved, with similar overall fold identical catalytic residues all organisms. Nonetheless, potentially differences exist between trypanosomatid...
In Trypanosoma cruzi, the causal agent of Chagas disease, first seven steps glycolysis are compartmentalized in glycosomes, which authentic but specialized peroxisomes. Besides glycolysis, activity enzymes other metabolic processes have been reported to be present such as β-oxidation fatty acids, purine salvage, pentose-phosphate pathway, gluconeogenesis and biosynthesis ether-lipids, isoprenoids, sterols pyrimidines. this study, we purified glycosomes from T. cruzi epimastigotes, collected...
Introduction. T. cruzi infections in humans have been extensively studied Venezuela, however, the reservoirs of disease little studied. Objective. The aim this study was to determine seroepidemiology dogs Sucre state, Venezuela. Materials and methods. This a cross-sectional prospective conducted 95 towns 577 dwellings 15 municipalities from August November 2008. Serum samples were tested by CruziELISA kit multiple antigens binding assay (MABA). In addition, epidemiological surveys undertaken...