A5080293807- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Virology and Viral Diseases
- Fire effects on ecosystems
- Parasites and Host Interactions
- Respiratory viral infections research
- Zoonotic diseases and public health
- Cervical Cancer and HPV Research
- Viral gastroenteritis research and epidemiology
- Gene expression and cancer classification
- Immunodeficiency and Autoimmune Disorders
- Livestock and Poultry Management
- Vector-borne infectious diseases
- Bayesian Methods and Mixture Models
- Genetics, Bioinformatics, and Biomedical Research
- SARS-CoV-2 detection and testing
- Genetic Associations and Epidemiology
- Dengue and Mosquito Control Research
- Hepatitis B Virus Studies
- vaccines and immunoinformatics approaches
Institut Pasteur de Dakar
2016-2025
Hôpital Européen Georges-Pompidou
2023
Ministère de la Santé Publique et Action Sociale
2023
Hôpital Européen
2023
Cheikh Anta Diop University
2011-2021
Sorbonne Paris Cité
2013-2020
Université Paris Cité
2011-2020
Institut Pasteur
2011-2020
Centre National de la Recherche Scientifique
2013-2020
Université Paris-Sud
2020
Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing Africa over the past year has led to a major increase number of sequences that have been generated and used track pandemic on continent, now exceeds 100,000 genomes. Our results show an African countries are able sequence domestically highlight local enables faster turnaround times more-regular routine surveillance. Despite limitations low testing proportions, findings from this genomic surveillance study...
The West Nile virus (WNV), isolated in 1937, is an arbovirus (arthropod-borne virus) that infects thousands of people each year. Despite its burden on global health, little known about the virus' biological and evolutionary dynamics. As several lineages are endemic Africa, we obtained complete polyprotein sequence from three isolates early 1990s, representing a different lineage. We then investigated differences growth behavior pathogenicity for four distinct African arthropod (Ap61) primate...
Malaria is one of the leading causes acute febrile illness (AFI) in Africa. With advent malaria rapid diagnostic tests, misdiagnosis and co-morbidity with other diseases has been highlighted by an increasing number studies. Although arboviral infections are both vector-borne often have overlapping geographic distribution sub-Saharan Africa, information about their incidence rates concurrent scarce. From July 2009 to March 2013 patients from seven healthcare facilities Kedougou region...
In the absence of a vaccine or specific treatments for Ebola virus disease (EVD), early identification cases is crucial control EVD epidemics. We evaluated new extraction kit (SpeedXtract (SE), Qiagen) on sera and swabs in combination with an improved diagnostic reverse transcription recombinase polymerase amplification assay detection (EBOV-RT-RPA). The performance combined was best swabs. Sensitivity specificity SE EBOV-RT-RPA were tested mobile laboratory consisting glovebox...
West Nile virus (WN virus) is one of the most widespread arbovirus and exhibits a great genetic diversity with 8 lineages, at least 4 (1, 2, Koutango, putative new) are present in Africa. In Africa, Culex neavei quinquefasciatus considered as potential vectors for WN transmission sylvatic or urban context. We analyzed vector competence these species from Senegal African lineages envelope proteins sequences viral strains used. showed that lineage 1 transmitted by both mosquitoes , whereas new...
Abstract After a period of heavy rainfall, an outbreak Rift Valley fever occurred in southern Mauritania during September–November 2012. A total 41 human cases were confirmed, including 13 deaths, and 12 virus strains isolated. Moudjeria Temchecket Departments the most affected areas.
Acute respiratory infections (ARIs) are the leading cause of infectious disease-related morbidity, hospitalization, and morbidity among children worldwide. This study aimed to assess viral bacterial causes ARI mortality in under 5 years Senegal. Nasopharyngeal samples were collected from who had ARI. Viruses bacteria identified using multiplex real-time reverse transcription-polymerase chain reaction conventional biochemical techniques, respectively. Adenovirus was most prevalent virus (50%;...
Abstract Rift Valley fever (RVF), which caused epizootics and epidemics among human livestock populations, occurred in Senegal 2013–2014. A multidisciplinary field investigation was carried out 3 regions of Senegal. We found 11 confirmed cases fever, including severe with encephalitis retinitis, 1 pool mosquito (Aedes ochraceus), 52 animals tested positive for the disease. Symptoms such as macular retinitis were most reported so far The outbreak widespread due to animals' movements, leading...
Abstract Early predictions forecasted large numbers of severe acute respiratory syndrome coronavirus (SARS-CoV-2) cases and associated deaths in Africa. To date, Africa has been relatively spared. Various hypotheses were postulated to explain the lower than anticipated impact on public health However, contribution pre-existing immunity is yet be investigated. In this study, presence antibodies against SARS-CoV-2 spike (S) nucleocapsid (N) proteins pre-pandemic samples from Africa, Europe,...
Background When vaccines against the novel COVID-19 were available in Senegal, many questions raised. How long should non-pharmaceutical interventions (NPIs) be maintained during vaccination roll-out? What are best strategies? Methods In this study, we used an age-structured dynamic mathematical model. This model uses parameters based on SARS-CoV-2 virus, information different types of NPIs, epidemiological and demographic data, some relating to hospitalisations Senegal. Results all...
In 2022, many regions around the world experienced a severe respiratory syncytial virus (RSV) epidemic with an earlier-than-usual start and increased numbers of paediatric patients in emergency departments. Here we carried out this study to describe epidemiology genetic characteristics RSV infection hospitalized acute infections 2022. Samples were tested for by multiplex real time reverse transcription polymerase chain reaction. Subsequently, subset positive samples was selected NGS...
Control efforts towards malaria due to Plasmodium falciparum significantly decreased the incidence of disease in many endemic countries including Senegal. Surprisingly, Kedougou (southeastern Senegal) P. remains highly prevalent and relative contribution other species global burden is very poorly documented, partly low sensitivity routine diagnostic tools. Molecular methods offer better estimate circulating a given area. A molecular survey was carried out document parasites region.A total...
Abstract Background Dengue fever is a mosquito born disease associated with self-limited to life threatening illness. First detected in Senegal the nineteenth century, and despite its growing incidence this last decade, significant knowledge gaps exist our of genetic diversity circulating strains. This study highlights serotypes genotypes between January 2017 December 2018 their spatial temporal distribution throughout all regions Senegal. Methods We used 56 dengue virus (DENV) strains for...
Crimean–Congo hemorrhagic fever (CCHF), the most widespread tick-borne viral human infection, poses a threat to global health. In this study, clinical samples collected through national surveillance systems were screened for acute CCHF virus (CCHFV) infection using RT-PCR and exposure ELISA. For any CCHF-positive sample, livestock tick also in neighborhood of confirmed case tested ELISA RT-PCR, respectively. Genome sequencing phylogenetic analyses performed on with positive results. Eastern...
Abstract In 2020, a sylvatic dengue virus serotype 2 infection outbreak resulted in 59 confirmed cases Kedougou, Senegal, suggesting those strains might not require adaptation to reemerge into urban transmission cycles. Large-scale genomic surveillance and updated molecular diagnostic tools are needed effectively prevent infections Senegal.
Abstract During 2015–2016, Cape Verde, an island nation off the coast of West Africa, experienced a Zika virus (ZIKV) outbreak involving 7,580 suspected cases and 18 microcephaly cases. Analysis complete genomes 3 ZIKV isolates from indicated strain was Asian (not African) lineage. The Verde sequences formed distinct monophylogenetic group possessed 1–2 (T659A, I756V) unique amino acid changes in envelope protein. Phylogeographic serologic evidence support earlier introduction this lineage...
Yellow fever virus remains a major threat in low resource countries South America and Africa despite the existence of an effective vaccine. In Senegal particularly eastern part country, periodic sylvatic circulation has been demonstrated with varying degrees impact on populations perpetual renewal. We report outbreak that occurred from October 2020 to February 2021 Senegal, notified managed through synergistic effort yellow national surveillance implemented by Senegalese Ministry Health...
A nationwide cross-sectional epidemiological survey was conducted to capture the true extent of coronavirus disease 2019 (COVID-19) exposure in Senegal. Multi-stage random cluster sampling households performed between October and November 2020, at end first wave COVID-19 transmission. Anti-severe acute respiratory syndrome 2 (SARS-CoV-2) antibodies were screened using three distinct ELISA assays. Adjusted prevalence rates for design calculated each test separately, thereafter combined. Crude...
Crimean-Congo hemorrhagic fever virus (CCHFV) is widespread in Asia, Europe, and Africa. In Senegal, sporadic cases of CCHFV have been reported since 1960. Bordering Mauritania northeastern Agnam an arid area the region Matam where endemic, which harbors a pastoralist community. Given drought conditions Agnam, inhabitants are constant movement with their animals search pasture, brings them into contact pathogens such as arboviruses. To identify this area, we established One Health site order...
West Nile virus (WNV) is a of the Japanese encephalitis antigenic complex and belongs to family Flaviviridae genus flavivirus. The can cause infection in humans which most cases asymptomatic, however symptomatic exist disease be severe causing meningoencephalitis. maintained an enzootic cycle involving mosquitoes birds, other mammals such as horses accidental hosts. A mosquito-based arbovirus surveillance system sentinel syndromic network (4S) have been place since 1988 2015 respectively,...
Historically low levels of seasonal influenza circulation were reported during the first years COVID-19 pandemic and mainly attributed to implementation nonpharmaceutical interventions. In tropical regions, influenza's seasonality differs largely, data on this topic are scarce. We analyzed from Senegal's sentinel syndromic surveillance network before after start assess changes in circulation. found that shows year-round Senegal has 2 distinct epidemic peaks: January-March rainy season...