A5044742023- Mosquito-borne diseases and control
- Malaria Research and Control
- Viral Infections and Vectors
- HIV/AIDS Research and Interventions
- Insect symbiosis and bacterial influences
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Computational Drug Discovery Methods
- COVID-19 epidemiological studies
- Parasites and Host Interactions
- Insect Pest Control Strategies
- Parasitic Diseases Research and Treatment
- Dengue and Mosquito Control Research
- Global Maternal and Child Health
- Insect Resistance and Genetics
- Diagnosis and treatment of tuberculosis
- Viral Infections and Outbreaks Research
- Virology and Viral Diseases
- HIV, Drug Use, Sexual Risk
- Diverse Scientific Research Studies
- COVID-19 and Mental Health
- Research on Leishmaniasis Studies
- Travel-related health issues
- Multiple Myeloma Research and Treatments
- Tuberculosis Research and Epidemiology
Instituto Nacional de Estatística
2019-2024
Universidade Nova de Lisboa
2024
Instituto Nacional de Saúde
2020-2023
Université Paris Cité
2020
Centre National de la Recherche Scientifique
2020
Université Paris-Saclay
2020
Université Paris-Sud
2020
The University of Sydney
2020
Sorbonne Paris Cité
2020
Institut Pasteur de Dakar
2020
Malaria in Cape Verde is unstable, with a sporadic and seasonal transmission of low endemicity. In this sense, the community perceptions regarding malaria transmission, their attitudes practices against disease are very important to understand better develop best strategical policies achieve elimination goal. This study aim assess knowledge, (KAP) Verdean population about malaria, country step disease.A cross-sectional KAP Survey was performed at household level. A structured open...
The extensive use of insecticides for vector control has led to the development insecticide resistance in Aedes aegypti populations on a global scale, which significantly compromised actions. Insecticide resistance, and its underlying mechanisms, been investigated several countries, mostly South American Asian countries. In Africa, however, studies reporting are rare data notably knockdown (kdr) mutations, is scarce. this study, recently described V410L kdr mutation reported first time old...
African populations of the mosquito Aedes aegypti are usually considered less susceptible to infection by human-pathogenic flaviviruses than globally invasive found outside Africa. Although this contrast has been well documented for Zika virus (ZIKV), it is unclear what extent true dengue (DENV), most prevalent flavivirus humans. Addressing question complicated substantial genetic diversity among DENV strains, notably in form four types (DENV1 DENV4), that can lead genetically specific...
Background Cabo Verde, an island country in West Africa, has been affected since human colonization by epidemics of vector-borne diseases with major dengue and zika recent years. Although there is a national program for integrated vector control, innovative strategies that reinforce routine activities strengthen control are necessary to prevent the emergence or reemergence arboviruses new zika. Insecticide paints evidenced as technologies formulation insecticides more residual safe way. The...
Abstract During 2015–2016, Cape Verde, an island nation off the coast of West Africa, experienced a Zika virus (ZIKV) outbreak involving 7,580 suspected cases and 18 microcephaly cases. Analysis complete genomes 3 ZIKV isolates from indicated strain was Asian (not African) lineage. The Verde sequences formed distinct monophylogenetic group possessed 1–2 (T659A, I756V) unique amino acid changes in envelope protein. Phylogeographic serologic evidence support earlier introduction this lineage...
Objectives: To characterize the genetic diversity and drug resistance profiles of people with HIV-1 failing ART in Cape Verde (CV). Design: Cross-sectional study conducted between January 2019 December 2021 24 health centres on islands Santiago São Vicente. Methods: The pol gene was sequenced individuals a detectable viral load. determined by phylogenetic analysis. Drug mutation patterns phenotypes were estimated using Stanford algorithm. Results: Viral load detected 73 252 (29%) enrolled...
Abstract Mosquitoes play a critical role as vectors of pathogens affecting both humans and animals. Therefore, understanding their biodiversity distribution is crucial to developing evidence-based vector control strategies. The current study updated the composition mosquito species through comprehensive survey all municipalities Cabo Verde. From October 2017 September 2018, larvae pupae were collected from 814 aquatic habitats. Anopheles gambiae (Giles, 1902) Culex pipiens (Linnaeus, 1758)...
HIV-1 infections remain a global public health concern. Scaled-up antiretroviral treatment (ART) is crucial for reducing morbidity and mortality related to HIV/AIDS. The emergence of drug-resistance mutations (DRMs) compromises viral suppression contributes the continued transmission. Several reports indicate recent increase in acquired (ADR) transmitted (TDR) drug resistance Africa, probably linked lack implementation HIV (HIVDR) testing suboptimal adherence. Herein, we will develop...
The explosive emergence of Zika virus (ZIKV) across the Pacific and Americas since 2007 was associated with hundreds thousands human cases severe outcomes, including congenital microcephaly caused by ZIKV infection during pregnancy. Although first isolated in Uganda, Africa has so far been exempt from large-scale epidemics, despite widespread susceptibility among African populations. A possible explanation for this pattern is natural variation populations primary vector ZIKV, mosquito Aedes...
Introduction The transmission of pathogens by blood-sucking insects to humans and other animals depends on vector-host interactions. As yet unexplored in Cape Verde, mosquito feeding behavior plays a crucial role pathogen transmission. Herein, we aim explore, through blood meal analysis, the relationship between species common hosts Santiago Island, Verde. Methods Engorged female mosquitoes were collected mechanical aspiration from May 2016 December 2017 three municipalities Island (Praia,...
Zika virus (ZIKV) diagnostics are crucial for proper antenatal and postnatal care also surveillance serosurvey studies. Since the viremia during ZIKV infection is fleeting, serological testing highly valuable to inform diagnosis. However, current serology tests using whole antigens frequently suffer from cross reactivity issues, delays, technical complexity, especially in low middle income countries (LMICs) endemic countries. Here, we describe an indirect ELISA detect specific IgG antibodies...
Wolbachia pipientis is an endosymbiont bacterium that induces cytoplasmic incompatibility and inhibits arboviral replication in mosquitoes. This study aimed to assess prevalence genetic diversity different mosquito species from Cape Verde. Mosquitoes were collected on six islands of Verde identified using morphological keys PCR-based assays. was detected by amplifying a fragment the surface protein gene (wsp). Multilocus sequence typing (MLST) performed with five housekeeping genes (coxA,...
The first case of COVID-19 in Cabo Verde was confirmed on March 19, 2020. Since the beginning pandemic country, government and health authorities have adopted restrictive measures to prevent spread SARS-CoV- 2 well as defined risk communication community involvement strategies. present study aimed at assessing knowledge, attitudes, practices Cape Verdean resident population towards COVID-19, support national system definition public policies related COVID-19.A cross-sectional conducted among...
Background: Mosquito-borne viruses, such as Zika, dengue, yellow fever, and chikungunya, are important causes of human diseases nearly worldwide. The greatest health risk for arboviral disease outbreaks is the presence most competent highly invasive domestic mosquito, Aedes aegypti. In Cabo Verde, two recent arbovirus were reported, a dengue outbreak in 2009, followed by Zika 2015. This study first entomological survey Ae. aegypti that includes all islands Verde archipelago, which we aim to...
Abstract Background Cape Verde is an archipelago located off the West African coast and in a pre-elimination phase of malaria control. Since 2010, fewer than 20 Plasmodium falciparum cases have been reported annually, except 2017, when outbreak Praia before rainy season led to 423 autochthonous cases. It important understand genetic diversity circulating P. inform on drug resistance, potential transmission networks sources infection, including parasite importation. Methods Enrolled subjects...
Background: Routine surveillance is a key pillar of malaria programs and the primary source data relied upon for decision-making, particularly in areas striving to achieve elimination. However, any inference when relying on routine inform decision-making limited by how effective system at measuring actual burden. Here, we extended freedom from infection (FFI) model framework produce species-specific estimates combined multiple components including community case management (CCM) active...
Background Integrated malaria vector control is crucial to eliminate or reduce infection risk. Understanding species distribution, behavior, and environmental factors such as climate, topography, preferred aquatic habitats essential. Objectives Herein, we aim compile data from 2016 2023 on the primary in Cabo Verde support health surveillance elimination certification. Materials methods Mosquitoes larvae were collected using standard sampling tools, adults Biogents Sentinel traps, mechanical...
Mosquito-borne diseases can pose significant burdens. In many countries, they a risk to national economies and the well-being of humans animals. To mitigate this, mosquito surveillance is crucial assess real potential transmission mosquito-borne diseases. Between 2020 2023, larvae were collected from both indoor outdoor breeding sites in urban rural areas 4 municipalities Santiago Boavista Islands Cabo Verde. Mosquitoes identified morphologically by polymerase chain reaction-based techniques...
The high genetic variability of HIV-1 and the emergence transmitted drug resistance (TDR) can impact treatment efficacy. In this study, we investigated prevalent genotypes drug-resistance-associated mutations in drug-naïve individuals Cabo Verde. conducted between 2018 2019, included from São Vicente, Boa Vista, Fogo, Santiago islands. pol gene was sequenced using Sanger sequencing. TDR identified Stanford Calibrated Population Resistance tool, levels to different drugs were interpreted with...
Abstract Background Cape Verde is an archipelago located off the West African coast, and in a pre-elimination phase of malaria control. Since 2010, less than 20 Plasmodium falciparum cases have been reported annually, except 2017, when outbreak Praia before rainy season led to 423 autochthonous cases. It important understand genetic diversity circulating P. inform on drug resistance, potential transmission networks, sources infection, including parasite importation. Methods Enrolled subjects...
The aim of this study was to characterize the genetic diversity and drug resistance profiles people with HIV-1 failing ART in Cape Verde (CV). This cross- sectional conducted between January 2019 December 2021 24 health centres on islands Santiago São Vicente. pol gene sequenced individuals a detectable viral load (VL). Phylogenetic analysis used determine diversity. Drug mutation patterns phenotypes were estimated using Stanford algorithm. VL detected 73 252 (29%) enrolled participants...
Abstract African populations of the mosquito Aedes aegypti are usually considered less susceptible to infection by human-pathogenic flaviviruses than globally invasive found outside Africa. Although this contrast has been well documented for Zika virus (ZIKV), it is unclear what extent true dengue (DENV), most prevalent flavivirus humans. Addressing question complicated substantial genetic diversity among DENV strains, notably in form four types (DENV1 DENV4), that can lead genetically...
Background: Determining the reproductive rate and how it varies over time space (RT) provides important insight to inform disease control. Estimating RT for malaria is difficult partly due widespread use of interventions immunity masking incident infections. A outbreak in Praia, Cabo Verde 2017 provided a unique opportunity estimate directly.Methods: was calculated using joint likelihood transmission between two cases, based on spatial proximity them. 321 442 confirmed cases reported were...
Background Determining the reproductive rate and how it varies over time space (R T ) provides important insight to understand transmission of a given disease inform optimal strategies for controlling or eliminating it. Estimating R malaria is difficult partly due widespread use interventions immunity masking incident infections. A outbreak in Praia, Cabo Verde 2017 provided unique opportunity estimate directly, providing proxy intensity vector-human contact measure impact vector control...