A5050933410- Malaria Research and Control
- Complement system in diseases
- Reproductive System and Pregnancy
- Parasites and Host Interactions
- Mosquito-borne diseases and control
- Pregnancy and preeclampsia studies
- Research on Leishmaniasis Studies
- COVID-19 Impact on Reproduction
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Genetics, Bioinformatics, and Biomedical Research
- Pregnancy and Medication Impact
- Gut microbiota and health
- Drug Transport and Resistance Mechanisms
- Viral gastroenteritis research and epidemiology
- Travel-related health issues
- Ovarian function and disorders
- Virology and Viral Diseases
- Biotechnology and Related Fields
- Bacteriophages and microbial interactions
- Endometriosis Research and Treatment
- Preterm Birth and Chorioamnionitis
- Natural Compound Pharmacology Studies
- Moringa oleifera research and applications
- Parvovirus B19 Infection Studies
Université de Yaoundé I
2014-2024
University of Lomé
2024
Rigshospitalet
2005-2013
Copenhagen University Hospital
2005-2013
University of Copenhagen
2005-2009
Georgetown University
2003
University of Scranton
2003
Otherwise clinically immune women in areas endemic for malaria are highly susceptible to Plasmodium falciparum during their first pregnancy. Pregnancy-associated (PAM) is characterized by placental accumulation of infected erythrocytes that adhere chondroitin sulfate A (CSA). Susceptibility PAM decreases with increasing parity, apparently due acquisition antibodies directed against the variant surface antigens (VSAs) mediate adhesion CSA (VSACSA). This study found levels VSACSA-specific...
Plasmodium falciparum-infected erythrocytes often are sequestered in the placenta and stimulate accumulation of maternal mononuclear cells. In this study, role that chemokines cytokines play mediating inflammatory response was investigated. Placental parasites elicited a statistically significant increase levels interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, plasma collected from intervillous space. Explants fetal tissue malaria-positive placentas also...
ABSTRACT During pregnancy, Plasmodium falciparum -infected erythrocytes sequester in the placenta by adhering to chondroitin 4-sulfate, creating a risk factor for both mother and fetus. The primigravidae are at higher placental malaria than multigravidae. This difference susceptibility has been attributed lack of antibodies that block adhesion infected 4-sulfate primigravid women. However, recent results show many term have antibody levels similar those multigravidae, thus significance...
ABSTRACT Pregnant women have an increased susceptibility to infection by Plasmodium falciparum . Parasites may be present in the placenta yet not detectable peripheral blood smears routine light microscopy. In order determine how frequently misdiagnosis occurs, and placental samples were collected from 1,077 Cameroonian at time of giving birth examined for presence malarial parasites using Results showed that 20.1% who had malaria smear negative. Thus, was detected microscopic examination...
Abstract Polymorphonuclear neutrophils (PMN) are key components of the inflammatory response contributing to development pathogen-specific immune responses. Following infection with Leishmania major, recruited within hours site parasite inoculation. C57BL/6 mice resistant infection, and BALB/c susceptible developing unhealing, lesions. In this report, we investigated expression cell surface integrins, TLRs, secretion immunomodulatory cytokines by PMN both strains mice, in L. major. The was...
Many plant polysaccharides have shown high antioxidant and immunostimulating properties can be explored as novel molecules with biological that potentially improve immune function. The objective of this work was to characterize soluble cell wall isolated from the stem bark Allanblackia floribunda Chromolaena odorata leaves evaluate their immunomodulatory properties. Three polysaccharide fractions: (PoS), pectins (Pec) hemicelluloses (Hem) were extracted A. C. leaves. These samples analysed...
The prevalence of pre-term deliveries (PTDs) is increased in women who become infected with Plasmodium falciparum during pregnancy. Because prematurity a risk factor for newborns, it important to identify conditions that contribute malaria-associated PTDs. falciparum-infected erythrocytes sequester the placenta and attract activated mononuclear cells secrete pro-inflammatory cytokines. Increased inflammatory cytokine levels other microbial infections are associated To determine if such case...
Plasmodium falciparum-infected erythrocytes (IEs) sequester in the intervillous space (IVS) of placenta causing placental malaria (PM), a condition that increases woman's chances having low-birth-weight baby. Because IEs sequester, they frequently are not observed peripheral blood smears, resulting women with PM being misdiagnosed and thus treated. sequestered induce inflammation IVS, detection inflammatory mediators may provide an approach for diagnosing PM. Two counterregulatory molecules,...
Background Impact of the pathophysiology Plasmodium falciparum placental malaria (PM) on profile some oxidative stress biomarkers and their relationship with poor pregnancy outcomes in women remain unknown. Methods Between 2013 2014, peripheral blood placenta tissue from 120 Cameroonian at delivery were assessed for maternal haemoglobin and, parasitaemia respectively. Parasite accumulation was investigated histologically. The levels Malondialdehyde (MDA), Nitric Oxide (NO), Superoxide...
The commensal microbes of the skin have a significant impact on dermal physiology and pathophysiology. Racial geographical differences in microbiome are suggested may play role sensitivity to dermatological disorders, including infectious diseases. However, little is known about profiles people living Central Africa, where severe tropical diseases impose burden inhabitants. This study provided healthy Cameroonians different body sites compared them Japanese participants. was distinguishable...
ABSTRACT Placenta-sequestering Plasmodium falciparum involved in the pathogenesis of pregnancy-associated malaria (PAM) otherwise clinically immune women expresses particular variant surface antigens (VSA PAM ) on infected erythrocytes that differ from VSA found parasitized nonpregnant individuals (non-PAM type VSA). We studied levels immunoglobulin G (IgG) and IgG subclasses with specificity for non-PAM pregnant two sites different endemicities Cameroon. -specific responses depended...
Placenta-sequestering Plasmodium falciparum parasites causing pregnancy-associated malaria express pregnancy-specific variant surface antigens (VSA(PAM)). We report here that VSA(PAM)-expressing patient isolates adhere strongly to the choriocarcinoma cell line BeWo and can be used efficiently select for VSA(PAM) expression in vitro.
A prospective longitudinal study of Plasmodium falciparum in pregnant women was conducted the rural village Ngali II, where malaria is hyperendemic and individuals receive ~0.7 infectious mosquito bites/person/day throughout year. Pregnant ( N = 60; 19 primigravidae, 41 multigravidae) were enrolled early pregnancy (median 14 wk) followed monthly, with 38 through term (5.7 ± 1.1 prenatal visits delivery). The total number times primigravidae slide-positive during higher than multigravidae...
Asymptomatic malarial parasitemia is highly prevalent in Plasmodium falciparum endemic areas and often associated with increased prevalence of mild to moderate anemia. The aim this study was assess the anemia during asymptomatic malaria its interplay persistent infection exposed individuals. A household-based longitudinal survey undertaken a hyperendemic area Cameroon using multiplex nested polymerase chain reaction detect plasmodial infections. Residents P. were monitored over 3-week period...
In support of ongoing immunologic studies on immunity to Plasmodium falciparum, demographic, entomologic, parasitologic, and clinical were conducted in two Cameroonian villages located 3 km apart. Simbok (population = 907) has pools water present year round that provide breeding sites for Anopheles gambiae, whereas Etoa 485) swampy areas dry up annually which A. funestus breed. Results showed individuals receive an estimated 1.9 1.2 infectious bites per night the wet season, respectively,...
The impact of placental malaria (PM) infection on the expression profile some cytokines known to regulate T cell differentiation and function their influence birth weight remain unclear. Moreover, there are no reports showing relationship between PM IL-27 or IL-28A. This study therefore sought investigate whether P. falciparum alters IL-28A, IL-27, IL-17E IL-6 in mothers new born. In a cross-sectional conducted 2013 2015 Yaoundé, Cameroon, peripheral, cord blood samples were collected from...
Abstract Although Th17 cells subsets improve immunity against extra and intracellular pathogens, in modulating Th1 other immune responses, its role on pregnancy‐associated malaria ( PAM ) is unknown. This study aims to investigate the effects of IFN ‐ γ , TNF α ), IL ‐10 family ‐10, ‐19, ‐22), ‐17A, ‐23) cytokines CXCL chemokine profiles pregnant women. Between 2010 2011, venous blood specimens from 107 volunteer Cameroonian women was used determine parasitaemia microscopically haemoglobin...
Abstract Background During childhood, residents of areas with stable transmission Plasmodium falciparum parasites acquire substantial protective immunity to malaria, and adults therefore rarely experience clinical disease episodes. However, susceptibility infection reappears in pregnant women, particularly primigravidae. This is due appearance antigenic parasite variants that are restricted pregnancy. Variant-specific also governs pregnancy-associated recrudescence berghei mice....
Background: Despite the wide use of leaves Myrianthus arboreus (Cecropiaceae) in several African countries including Cameroon as food and against amenorrhea female infertility, it has never been tested for this purpose. Methods: Using immature Wistar rats, impact M. on sexual maturation parameters (vaginal opening, ovarian relative weight follicle maturation, gonadotropins hormones serum levels) fertility index evaluated through a 30-day oral administration aqueous methanol extracts at doses...
Introduction Depending on the microenvironment, γδ T cells may assume characteristics similar to those of Th1, Th2, Th17, regulatory or antigen presenting cells. Despite wide documentation effect Th1/Th2 balance pregnancy associated malaria and outcomes, there are no reports relationship between cell phenotype change Placental Malaria (PM) with outcomes. This study sought investigate involvement its subsets in placental Plasmodium falciparum malaria. Methods In a case-control conducted...
Between 1995 and 1998, a longitudinal study was conducted at 2 health centers in Cameroon to determine the prevalence of Plasmodium falciparum infection pregnant women. There were 520 women enrolled rural clinic village Etoa 199 Biyem Assi Clinic city Yaounde. In Etoa, younger, fewer took prophylaxis, malaria higher compared with Clinic. The peaked during fourth month pregnancy both sites. Age identified as major risk factor because < or = 20 years old 1.8 3.4 times more likely have than...
We have investigated the immunological basis of pregnancy-related Plasmodium berghei recrudescence in immune mice with substantial preexisting immunity. Specifically, we examined relevance this experimental model to study pregnancy-associated malaria (PAM) caused by P. falciparum women protective used immunity induced prior pregnancy and employed flow cytometry assess their levels immunoglobulin G (IgG) recognizing antigens on surfaces infected erythrocytes (IEs) plasma. After immunization,...