A5008106781- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Reproductive System and Pregnancy
- COVID-19 Clinical Research Studies
- Pregnancy and preeclampsia studies
- Complement system in diseases
- SARS-CoV-2 detection and testing
- COVID-19 diagnosis using AI
- Vector-borne infectious diseases
- COVID-19 Impact on Reproduction
- Virology and Viral Diseases
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Tuberculosis Research and Epidemiology
- Research on Leishmaniasis Studies
- Hepatitis C virus research
- Insect Pest Control Strategies
- Pregnancy and Medication Impact
- Trypanosoma species research and implications
- Viral Infections and Immunology Research
- Global Maternal and Child Health
- Vaccine Coverage and Hesitancy
- Congenital Heart Disease Studies
Fondation Congolaise Pour La Recherche Médicale
2022-2025
University of Tübingen
2025
Université de Yaoundé I
2014-2024
National Institute of Biomedical Research
2022
University of Kinshasa
2022
Abstract Background Malaria remains a major public health problem in the Republic of Congo, with Plasmodium falciparum being deadliest species humans. Vector transmission malaria is poorly studied country and no previous report compared rural urban data. This study aimed to determine Anopheles fauna entomological indices areas south Brazzaville, beyond. Methods Indoor household mosquitoes capture using electric aspirator was performed during raining dry seasons 2021. The identification done...
Abstract Background Data suggest excess mortality is associated with loiasis, which endemic to Central Africa, although the underlying mechanisms remain unknown. We hypothesized that there could be an association between Loa loa microfilarial densities (MFD) and lower spleen volume (SV) due micro-obstruction linked circulating microfilariae (mf). This result in functional hyposplenia a higher burden of infections. Our objective was investigate impact L. MFD malaria on spleen’s bi-dimensional...
Background Impact of the pathophysiology Plasmodium falciparum placental malaria (PM) on profile some oxidative stress biomarkers and their relationship with poor pregnancy outcomes in women remain unknown. Methods Between 2013 2014, peripheral blood placenta tissue from 120 Cameroonian at delivery were assessed for maternal haemoglobin and, parasitaemia respectively. Parasite accumulation was investigated histologically. The levels Malondialdehyde (MDA), Nitric Oxide (NO), Superoxide...
Abstract Background Although Plasmodium falciparum infection is largely documented and this parasite the main target for malaria eradication, other species persist, these require more attention in Africa. Information on epidemiological situation of non- P. infections scarce many countries, including Democratic Republic Congo (hereafter Congo) where highly endemic. The aim study was to determine prevalence distribution region south Brazzaville. Methods A cross-sectional survey conducted...
Plasmodium falciparum parasites carrying deletions of histidine-rich protein 2 and 3 genes, pfhrp2 pfhrp3, respectively, are likely to escape detection via HRP2-based rapid diagnostic tests (RDTs) and, consequently, treatment, posing a major risk both the health infected individual malaria control efforts. This study assessed frequency pfhrp2- pfhrp3-deleted strains at four different sites in Central Africa (number samples analyzed: Gabon N = 534 Republic Congo 917) West Nigeria 466 Benin...
Abstract Background Mosquitoes belonging to the Anopheles gambiae sensu lato complex play a major role in malaria transmission across Africa. This study assessed relative importance of members An. s.l. two rural villages Republic Congo. Methods Adult mosquitoes were collected using electric aspirators from June September 2022 Djoumouna and Ntoula sorted by taxa based on their morphological features. females also molecularly identified. A TaqMan-based assay nested polymerase chain reaction...
Current malaria diagnostic methods require blood collection, that may be associated with pain and the risk of transmitting blood-borne pathogens, often create poor compliance when repeated sampling is needed. On other hand, collection saliva minimally invasive; but has not been widely used for diagnosis malaria. The aim this study was to evaluate performance collected stored at room temperature using OMNIgene®•ORAL kit diagnosing Plasmodium falciparum Paired samples were from 222 febrile...
The impact of placental malaria (PM) infection on the expression profile some cytokines known to regulate T cell differentiation and function their influence birth weight remain unclear. Moreover, there are no reports showing relationship between PM IL-27 or IL-28A. This study therefore sought investigate whether P. falciparum alters IL-28A, IL-27, IL-17E IL-6 in mothers new born. In a cross-sectional conducted 2013 2015 Yaoundé, Cameroon, peripheral, cord blood samples were collected from...
With limited data available from Central Africa, the aim of our study was to evaluate anti-SARS-CoV-2 Ab prevalence in indigenous residents Bomassa, a village located Sangha region Republic Congo.Plasma and oropharyngeal swab samples were collected 304 healthy adult individuals, randomly recruited May 2021 before vaccine introduction area. In addition, 82 plasma same area 2019 included as controls for investigation cross-reactivity against other coronaviruses. The SARS-CoV-2 virus detected...
Assessing immune responses after vaccination is part of the evaluation package vaccine effectiveness in real world. Regarding SARS-CoV-2, neutralizing antibody levels has been shown to be a good indicator response boosting. So far, limited data have reported from Africa including Central Africa. The objective this study was provide on anti-S1 spike total IgG and antibodies vaccinated non-vaccinated naturally infected Congolese population during B.1.214.1 B.1.617.2 variant waves.
Abstract Although Th17 cells subsets improve immunity against extra and intracellular pathogens, in modulating Th1 other immune responses, its role on pregnancy‐associated malaria ( PAM ) is unknown. This study aims to investigate the effects of IFN ‐ γ , TNF α ), IL ‐10 family ‐10, ‐19, ‐22), ‐17A, ‐23) cytokines CXCL chemokine profiles pregnant women. Between 2010 2011, venous blood specimens from 107 volunteer Cameroonian women was used determine parasitaemia microscopically haemoglobin...
Abstract Background Human African trypanosomiasis (HAT) is one of the world’s classical neglected tropical diseases representing a major public health threat in sub-Saharan Africa. Although parasitic disease decline Republic Congo, better understanding epidemiological situation active foci required to reduce risk resurgence which could impede progress registered so far. The aim this study was determine prevalence HAT and associated factors individuals living remote areas Congo. Methods A...
Polymorphisms in the genes encoding merozoite surface proteins msp-1 and msp-2 are widely used markers for characterizing genetic diversity of Plasmodium falciparum. This study aimed to compare circulating parasite strains rural urban settings Republic Congo after introduction artemisinin-based combination therapy (ACT) 2006. A cross-sectional survey was conducted from March September 2021 areas close Brazzaville, during which infection detected using microscopy (and nested-PCR...
Introduction Depending on the microenvironment, γδ T cells may assume characteristics similar to those of Th1, Th2, Th17, regulatory or antigen presenting cells. Despite wide documentation effect Th1/Th2 balance pregnancy associated malaria and outcomes, there are no reports relationship between cell phenotype change Placental Malaria (PM) with outcomes. This study sought investigate involvement its subsets in placental Plasmodium falciparum malaria. Methods In a case-control conducted...
Abstract Objective HIV has been reported to interfere with protective vaccination against multiple pathogens, usually through the decreased effectiveness of antibody responses. We aimed assess neutralizing responses induced by COVID-19 in PLWH Brazzaville, Republique Congo. Method The study was conducted at Ambulatory Treatment Center National Program, charge over 6000 PLWH, and health center FCRM Republic Participants were divided into two groups: well-controlled infection (CD4 counts no...
Malaria blood-stage parasite is a critical pathogenic stage responsible for serious adverse outcomes in pregnant women and their neonates. Immunoglobulin G (IgG) antibody responses specific to various asexual antigens were well reported non-pregnant individuals. However, little still known during placental malaria. To assess the Plasmodium falciparum-derived MSP3 UB05 malaria vaccine candidates mother-neonate couples, mother's peripheral blood neonate's cord samples collected at delivery....
This study aimed to analyze polymorphisms in Pfcrt, Pfmdr1, and Pfk13 genes' markers of resistance Artemisinin-based combination therapy (ACT), Plasmodium falciparum isolates from southern Brazzaville, 15 years after the adoption ACT Republic Congo. A total 369 microscopy-confirmed malaria-infected individuals were enrolled March October 2021 community health facilities during a cross-sectional study. The K76T mutation Pfcrt gene, N86Y Y184F mutations Pfmdr1 gene investigated using...
Plasmodium falciparum infected erythrocytes sequestering in placental tissue release lactate dehydrogenase (pLDH) and histidine-rich protein-II (HRP-II). These proteins can be detected peripheral blood using monoclonal antibody-based rapid diagnostic tests (RDTs). Nevertheless, studies to evaluate the reliability of RDTs detecting malaria compared with microscopy impression smear (PTIS) as gold standard are scarce. Between August 2013 January 2015, Giemsa-stained smears for (Pbs),...
Investigating whether the multiplicity of Plasmodium falciparum infection (MOI) is related to pregnancy outcomes, interest in sub-Saharan area where malaria highly endemic. The present study aimed characterize genetic diversity P. women at delivery from Southern Brazzaville, and investigate MOI associated with maternal anaemia, preterm delivery, or low birth weight.This was a cross sectional carried out samples collected between March 2014 April 2015 371 recruited Health Centre southern...
Background Co-infection with malaria and intestinal parasites is common in children Africa may affect their immune response to a parasite infection. Prior studies suggest that co-infections lead increased susceptibility infection disease severity; however, other have shown the reverse. Knowledge on how co-morbidities specifically antigens limited. Therefore, this study sought determine prevalence of co-infection its association antibody levels merozoite antigens. Methods A cross sectional...
In pregnancy-associated malaria, chemokines such as CXCL-4, CXCL-13, CXCL-16, and CCL-24 play critical roles in leucocyte trafficking to tissue sites the infected placenta where inflammatory reactions are active. However, how plasma levels of these associate with Plasmodium falciparum placental malaria pregnancy outcomes remains not well understood. The present study analyzed matched peripheral, cord blood relation (PM), submicroscopic parasitaemia. This was a retrospective case-control (1:3...
The efficacy of immunization against an airborne pathogen depends in part on its ability to induce antibodies at the major entry site virus, mucosa. Recent studies have revealed that mucosal immunity is poorly activated after vaccination with messenger RNA vaccines, thus failing blocking virus acquisition upon initial exposure. Little information available about induction by inactivated and recombinant coronavirus disease 2019 (COVID-19) vaccines. This study aims investigate this topic.