A5059370284- Malaria Research and Control
- Mosquito-borne diseases and control
- Complement system in diseases
- Parasites and Host Interactions
- Travel-related health issues
- Reproductive System and Pregnancy
- Vector-borne infectious diseases
- Bioactive Natural Diterpenoids Research
- Immune Cell Function and Interaction
- Biological Stains and Phytochemicals
- Pregnancy and preeclampsia studies
- Essential Oils and Antimicrobial Activity
- Adrenal Hormones and Disorders
- Computational Drug Discovery Methods
- Tuberculosis Research and Epidemiology
Inserm
2023-2024
Université de Montpellier
2023-2024
Centre National de la Recherche Scientifique
2023-2024
Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle
2023-2024
Université de Yaoundé I
2018-2024
Centre Pasteur du Cameroun
2019-2024
Agropolis International
2024
Abstract Background Chronic carriage of asymptomatic low-density Plasmodium falciparum parasitaemia in the dry season may support maintenance acquired immunity that protects against clinical malaria. However, relationship between chronic infections and subsequent risk malaria episodes remains unclear. Methods In a 2-years study (December 2014 to December 2016) eastern Gambia, nine cross-sectional surveys using molecular parasite detection were performed wet season. During 2016 transmission...
Asymptomatic malarial parasitemia is highly prevalent in Plasmodium falciparum endemic areas and often associated with increased prevalence of mild to moderate anemia. The aim this study was assess the anemia during asymptomatic malaria its interplay persistent infection exposed individuals. A household-based longitudinal survey undertaken a hyperendemic area Cameroon using multiplex nested polymerase chain reaction detect plasmodial infections. Residents P. were monitored over 3-week period...
Presence of mature gametocyte forms malaria parasites in peripheral blood is a key requirement for transmission. Yet, studies conducted most transmission zones report the absence majority patients. We therefore sought to determine risk factors both all-stage and carriage an area with high stable Plasmodium falciparum Cameroon. Gametocyte positivity was determined using three complementary methods: thick smear microscopy, RT-PCR RT-LAMP, whereas exposure infection assessed by enzyme-linked...
Introduction Depending on the microenvironment, γδ T cells may assume characteristics similar to those of Th1, Th2, Th17, regulatory or antigen presenting cells. Despite wide documentation effect Th1/Th2 balance pregnancy associated malaria and outcomes, there are no reports relationship between cell phenotype change Placental Malaria (PM) with outcomes. This study sought investigate involvement its subsets in placental Plasmodium falciparum malaria. Methods In a case-control conducted...
The applicability of the specific human IgG antibody response to Anopheles gambiae salivary Gland Protein-6 peptide 1 (gSG6-P1 peptide) as a biomarker able distinguish level exposure mosquito bites according seasonal variations has not yet been evaluated in Central African regions. study aimed provide first reliable data on anti-gSG6-P1 rural area Cameroon dry- and rainy-season. Between May December 2020, dry blood samples were collected from people living Bankeng village forest Centre...
Plasmodium falciparum infected erythrocytes sequestering in placental tissue release lactate dehydrogenase (pLDH) and histidine-rich protein-II (HRP-II). These proteins can be detected peripheral blood using monoclonal antibody-based rapid diagnostic tests (RDTs). Nevertheless, studies to evaluate the reliability of RDTs detecting malaria compared with microscopy impression smear (PTIS) as gold standard are scarce. Between August 2013 January 2015, Giemsa-stained smears for (Pbs),...
Malaria remains a major public health problem worldwide, with eradication efforts thwarted by drug and insecticide resistance the lack of broadly effective malaria vaccine. In continuously exposed communities, polyclonal infections are thought to reduce risk severe disease promote establishment asymptomatic infections. We sought investigate relationship between complexity P. falciparum infection underlying host adaptive immune responses in an area high prevalence parasitaemia Cameroon. A...
Malaria remains a major public health problem worldwide, with eradication efforts thwarted by drug and insecticide resistance the lack of broadly effective malaria vaccine. In continuously exposed communities, polyclonal infections are thought to reduce risk severe disease promote establishment asymptomatic infections. We sought investigate relationship between complexity P. falciparum infection underlying host adaptive immune responses in an area high prevalence parasitaemia Cameroon. A...
Malaria remains a widespread health problem with huge burden. Severe or complicated malaria is highly lethal and encompasses variety of pathological processes, including immune activation, inflammation, dysmetabolism. Previously, we showed that adrenal hormones, in particular glucocorticoids (GCs), play critical roles to maintain disease tolerance during Plasmodium infection mice. Here, GC responses were studied Cameroon children uncomplicated (UM), severe (SM) asymptomatic controls (AC). To...
Light microscopy and rapid diagnostic tests are the two commonly used methods for malaria diagnosis that rely on direct use of unprocessed blood samples. However, both do not have level sensitivity required in cases low density parasitaemia. We report here performance a whole blood-based reverse transcription loop-mediated isothermal amplification method Plasmodium falciparum apparently healthy donors febrile neonates Cameroon. The presence parasites samples was determined by light...
Recent developments in cancer research indicate that is a manifestation of immune system dysfunction. Many natural anticancer agents developed recently possess immune-modulatory properties. In our ongoing pursuit alternatives, we evaluated the potential oligandrin, an ent-pimarane type diterpenoid from
Abstract Background In Africa, the clearance time for P. falciparum severe malaria varies significantly, likely due to complexity of infections and sequestration phenomenon exhibited by this parasite. This study aims evaluate different methods intra-host dynamics polygenomic during parasite under antimalarial treatment. Additionally, it seeks determine association between rate following artesunate or quinine treatment genetic in Beninese children with malaria. Methods Sixty-five individuals...
Abstract Background Chronic carriage of asymptomatic low-density Plasmodium falciparum parasitaemia in the dry season may support maintenance acquired immunity that protects against clinical malaria. However, relationship between chronic infections and subsequent risk malaria episodes remains unclear. Methods In a 2-years study (December 2014 to December 2016) eastern Gambia, nine cross-sectional surveys using molecular parasite detection were performed wet season. During 2016 transmission...
Abstract With over 200 million clinical cases per year leading to 600,000 deaths, malaria is still a significant global health problem. Up 80% of individuals in some malaria-endemic areas can have asymptomatic carriage Plasmodium infections (no overt symptoms) and are thought be reservoir for transmission. Many Plasmodium-infected show mild anemia vascular activation an increased risk co-morbidities such as typhoidal Salmonella. Currently, the immunological mechanisms governing poorly...
Background The appropriate balance between anti-inflammatory and pro-inflammatory cytokines is necessary for protection against pregnancy-associated malaria poor pregnancy outcomes. This study therefore aims to investigate the relationship plasma levels of some regulatory P. falciparum infection in Cameroonian women during pregnancy. Methods Peripheral blood was collected from 131 27 non-pregnant living Mbalmayo area May December 2014. Parasitaemia determined by microscopy haemoglobin level...
Abstract Background Asymptomatic carriage of infected red blood cells (iRBCs) can be prevalent in communities regardless transmission patterns and occur with infection different Plasmodium species. Clinical immunity dampens the inflammatory responses leading to disease symptoms malaria. The aim this study was define immunological correlates asymptomatic P. falciparum a highly exposed population. Methods 142 -infected individuals greater than 2 years age without fever (body temperature...