A5026296866- Malaria Research and Control
- Mosquito-borne diseases and control
- Travel-related health issues
- Computational Drug Discovery Methods
- Parasite Biology and Host Interactions
- HIV/AIDS drug development and treatment
- Parasites and Host Interactions
- Viral Infections and Vectors
- Invertebrate Immune Response Mechanisms
- Complement system in diseases
- Glycosylation and Glycoproteins Research
- Microbial infections and disease research
MRC Unit the Gambia
2016-2025
Max Planck Institute for Infection Biology
2024
Abstract Background Chronic carriage of asymptomatic low-density Plasmodium falciparum parasitaemia in the dry season may support maintenance acquired immunity that protects against clinical malaria. However, relationship between chronic infections and subsequent risk malaria episodes remains unclear. Methods In a 2-years study (December 2014 to December 2016) eastern Gambia, nine cross-sectional surveys using molecular parasite detection were performed wet season. During 2016 transmission...
Abstract Background In areas where Plasmodium falciparum malaria is seasonal, a dry season reservoir of blood-stage infection essential for initiating transmission during the following wet season. Methods The Gambia, cohort 42 individuals with quantitative polymerase chain reaction-positive P infections at end (December) were followed monthly until (May) to evaluate persistence. influence human host and parasitological factors was investigated. Results A large proportion infected had...
Genome sequences of 247 Plasmodium falciparum isolates collected in The Gambia 2008 and 2014 were analysed to identify changes possibly related the scale-up antimalarial interventions that occurred during this period. Overall, there 15 regions across genomes with signatures positive selection. Five these sweeps around known drug resistance antigenic loci. Signatures at loci such as thrombospodin adhesive protein (Pftrap) most frequent eastern Gambia, where parasite prevalence transmission...
Understanding the genetic diversity and transmission dynamics of Plasmodium falciparum , causative agent malaria, is crucial for effective control elimination efforts. In some endemic regions, malaria highly seasonal with no or little during up to 8 months, yet known about how seasonality affects parasite population genetics. Here we conducted a longitudinal study over 2.5 years on 1516 participants in Upper River Region The Gambia. With 425 P. barcodes genotyped from asymptomatic...
Antimalarial interventions have yielded a significant decline in malaria prevalence The Gambia, where artemether-lumefantrine (AL) has been used as first-line antimalarial for decade. Clinical Plasmodium falciparum isolates collected from 2012 to 2015 were analyzed ex vivo susceptibility and genotyped drug resistance markers (pfcrt K76T, pfmdr1 codons 86, 184, 1246, pfk13) microsatellite variation. Additionally, allele frequencies of single nucleotide polymorphisms (SNPs) other...
Previous genome-wide analyses of single nucleotide variation in Plasmodium falciparum identified evidence an extended haplotype region on chromosome 6 West Africa, suggesting recent positive selection. Such a pattern is not seen samples from East Africa or South Asia, so it could be marking selective process specific to Africa. Analyses the structure taken at different times give clues possible causes This study investigates haplotypes The Gambia by analysing alleles multiple microsatellite...
Abstract Plasmodium falciparum is believed to escape immunity via antigenic variation, mediated in part by 60 var genes. These genes undergo mutually exclusive expression and encode the PfEMP1 surface antigen. The frequency of switching immunogenicity each expressed remain unclear. To this end, we carried out a Controlled Human Malaria Infection (CHMI) study with 19 adult African volunteers Gambia gain insight into effect naturally acquired on gene repertoire during early phase an infection....
Abstract Understanding the genetic diversity and transmission dynamics of Plasmodium falciparum , causative agent malaria, is crucial for effective control elimination efforts. In some endemic regions, malaria highly seasonal with no or little during up to 8 months, yet known about how seasonality affects parasite population genetics. Here we conducted a longitudinal study over 2.5 year on 1516 participants in Upper River Region The Gambia. With 425 P. barcodes genotyped from asymptomatic...
Understanding the genetic diversity and transmission dynamics of Plasmodium falciparum , causative agent malaria, is crucial for effective control elimination efforts. In some endemic regions, malaria highly seasonal with no or little during up to 8 months, yet known about how seasonality affects parasite population genetics. Here we conducted a longitudinal study over 2.5 year on 1516 participants in Upper River Region The Gambia. With 425 P. barcodes genotyped from asymptomatic infections,...
Understanding the genetic diversity and transmission dynamics of Plasmodium falciparum , causative agent malaria, is crucial for effective control elimination efforts. In some endemic regions, malaria highly seasonal with no or little during up to 8 months, yet known about how seasonality affects parasite population genetics. Here we conducted a longitudinal study over 2.5 year on 1516 participants in Upper River Region The Gambia. With 425 P. barcodes genotyped from asymptomatic infections,...
In seasonal transmission areas, clinical malaria occurs during the wet season when mosquitoes are present, while in dry season, is interrupted and cases rare. Mali, Plasmodium falciparum can persist low parasitaemic asymptomatic individuals through six-month shows reduced cytoadhesion of infected erythrocytes, evidenced by circulation further developed parasite stages compared to cases. How prolonged erythrocytes achieved remains unknown. Here, we explored var gene expression subclinical...
Abstract Background Chronic carriage of asymptomatic low-density Plasmodium falciparum parasitaemia in the dry season may support maintenance acquired immunity that protects against clinical malaria. However, relationship between chronic infections and subsequent risk malaria episodes remains unclear. Methods In a 2-years study (December 2014 to December 2016) eastern Gambia, nine cross-sectional surveys using molecular parasite detection were performed wet season. During 2016 transmission...
Abstract Background In areas where Plasmodium falciparum malaria is highly seasonal, a dry season reservoir of blood-stage infection essential for initiating transmission during the following wet season, bridging seasons several months apart. Understanding infections could thus inform approaches control. Methods The Gambia, cohort 42 individuals with qPCR positive P. at end (December) were followed monthly until (May) to evaluate duration detectable infections. influence human host (age,...