A5026256846- Malaria Research and Control
- Mosquito-borne diseases and control
- Complement system in diseases
- vaccines and immunoinformatics approaches
- Insect symbiosis and bacterial influences
- HIV Research and Treatment
- Migration, Health and Trauma
- Dengue and Mosquito Control Research
- Entomopathogenic Microorganisms in Pest Control
- Microbial infections and disease research
- Invertebrate Immune Response Mechanisms
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- Plant and animal studies
- Insect and Arachnid Ecology and Behavior
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Parasites and Host Interactions
- COVID-19 and Mental Health
- Virology and Viral Diseases
- COVID-19 and healthcare impacts
- Aquaculture disease management and microbiota
- Vector-borne infectious diseases
- Bacterial Infections and Vaccines
- Hemoglobinopathies and Related Disorders
University of Maryland, Baltimore
2016-2025
University of Baltimore
2019-2023
International Centers for Excellence in Research
2023
National Institute of Malaria Research
2017
Howard Hughes Medical Institute
2013-2015
Centro Hospitalar Tondela-Viseu
2015
National Institutes of Health
2014
Boston Children's Hospital
2007
University of Bamako
2003
Harvard University
2000-2002
Despite the widespread implementation of public health measures, coronavirus disease 2019 (COVID-19) continues to spread in United States. To facilitate an agile response pandemic, we developed How We Feel, a web and mobile application that collects longitudinal self-reported survey responses on health, behaviour demographics. Here, report results from over 500,000 users States 2 April 2020 12 May 2020. show surveys can be used build predictive models identify likely COVID-19-positive...
Abstract SARS-CoV-2 vaccines are useful tools to combat the Coronavirus Disease 2019 (COVID-19) pandemic, but vaccine reluctance threatens these vaccines’ effectiveness. To address COVID-19 and ensure equitable distribution, understanding extent of factors associated with acceptance uptake is critical. We report results a large nationwide study in US conducted December 2020-May 2021 36,711 users from COVID-19-focused smartphone-based app How Feel on their willingness receive vaccine....
Plasmodium falciparum (Pf) whole-organism sporozoite vaccines have been shown to provide significant protection against controlled human malaria infection (CHMI) in clinical trials. Initial CHMI studies showed significantly higher durable homologous than heterologous strains, suggesting the presence of strain-specific vaccine-induced protection. However, interpretation these results and understanding their relevance vaccine efficacy hampered by lack knowledge on genetic differences between...
The recent decline in malaria incidence many African countries has been attributed to the provision of prompt and effective anti-malarial treatment using artemisinin-based combination therapy (ACT) widespread distribution long-lasting, insecticide-treated bed nets (LLINs). At a vaccine-testing site Bandiagara, Mali, ACT was introduced 2004, LLINs have distributed free charge since 2007 infants after they complete Expanded Programme Immunization (EPI) schedule pregnant women receiving...
Abstract There have been several significant outbreaks of COVID-19 in federal immigrant detention centers, which lack clear and consistent guidelines across Department Homeland Security (DHS) agencies to limit the spread COVID-19. The Centers for Disease Control Prevention (CDC) has issued detailed control, prevention, evaluation facilities. Although DHS’s Immigration Customs Enforcement agency stated that it complies with CDC recommendations, its policies significantly differ from these...
Abstract While sulfadoxine-pyrimethamine has been the primary drug in intermittent preventive treatment pregnancy, dihydroartemisinin-piperaquine (DP) is being considered as an alternative. DP may lead to lower antimalarial antibodies mother, resulting higher risk of malaria infancy. We probed cord blood sera collected from women enrolled a clinical trial vs on protein microarray containing diverse Plasmodium falciparum erythrocyte membrane proteins 1 measure impact pregnancy associated with...
The repetitive interspersed family (rif) and subtelomeric variable open reading frames (stevor) are highly diverse multi-gene families in the malaria parasite Plasmodium falciparum. Embedded on surface of infected erythrocytes, RIFIN STEVOR proteins involved cytoadherence immune evasion, but extent family-wide sequence diversity across strains has yet to be comprehensively investigated light improved resolution genome sequences. Using a k-mer frequency approach, we analyzed long-read genomic...
Heterogeneous patterns of malaria transmission are thought to be driven by factors including host genetics, distance mosquito breeding sites, housing construction, and socio-behavioural characteristics. Evaluation local epidemiology characterize risk is essential for planning control elimination programmes. The use geographical information systems (GIS) techniques has been a major asset this approach. To assess time space distribution disease in Bandiagara, Mali, within season, data were...
In areas of seasonal malaria transmission, the incidence rate infection is presumed to be near zero at end dry season. Asymptomatic individuals may constitute a major parasite reservoir during this time. We conducted longitudinal analysis spatio-temporal distribution clinical and asymptomatic parasitemia over time in Malian town highlight these transmission dynamics. For cohort 300 rural children followed 2009-2014, periodicity phase shift between rainfall were determined by spectral...
Abstract SARS-CoV-2 vaccines are powerful tools to combat the COVID-19 pandemic, but vaccine hesitancy threatens these vaccines’ effectiveness. To address and ensure equitable distribution, understanding extent of factors associated with is critical. We report results a large nationwide study conducted December 2020-January 2021 34,470 users from COVID-19-focused smartphone-based app How Feel on their willingness receive vaccine. Nineteen percent respondents expressed hesitancy, majority...
Variant surface antigens (VSAs) play a critical role in severe malaria pathogenesis. Defining gaps, or "lacunae", immunity to these Plasmodium falciparum children with would improve our understanding of vulnerability and how protective develops. Using protein microarray 179 antigen variants from three VSA families as well more than 300 other blood stage P. antigens, reactivity was measured sera Malian cerebral malarial anaemia age-matched controls. Sera recognized fewer extracellular PfEMP1...
Abstract Vaccines based on Plasmodium falciparum apical membrane antigen 1 (AMA1) have failed due to extensive polymorphism in AMA1. To assess the strain-specificity of antibody responses malaria infection and AMA1 vaccination, we designed protein peptide microarrays representing hundreds unique variants. Following clinical episodes, children had short-lived, sequence-independent increases average whole-protein seroreactivity, as well strain-specific peptides diverse epitopes. Vaccination...
Plasmodium parasites caused 241 million cases of malaria and over 600,000 deaths in 2020. Both P. falciparum ovale are endemic to Mali cause clinical malaria, with infections typically being more severe. Here, we sequenced RNA from nine pediatric blood samples collected during either or ovale, characterized the host parasite gene expression profiles. We found that human varies between individuals than according species causing infection, while profiles cluster by species. Additionally, DNA...
BACKGROUND: Giardia is the most frequently identified intestinal parasite in North America. Although information on geographical distribution of giardiasis critical identifying communities at high risk, little has been done this area. Therefore, objective study was to investigate and temporal human Ontario order identify possible risk areas seasons. Two spatial scales analyses two disease measures were used with a view best each assessing patterns Ontario. Global Moran's I Moran Local...
Hemoglobin C trait, like hemoglobin S protects against severe malaria in children, but it is unclear whether trait also uncomplicated malaria. We hypothesized that Malian children with would have a lower risk of clinical than AA.Three hundred aged 0-6 years were enrolled cohort study incidence Bandiagara, Mali, continuous passive and monthly active follow-up from June 2009 to 2010.Compared AA (n = 242), AC 39) had longer time first episode (hazard ratio [HR], 0.19; P .001; 364 median...
Objective Demographic and health surveys, immunization coverage surveys administrative data often divergently estimate vaccination coverage, which hinders pinpointing districts where services require strengthening. We assayed in three regions Ethiopia by linked serosurveys. Methods Households with children aged 12–23 (N = 300) or 6–8 months 100) each of (woredas) were randomly selected for (inspection cards clinic records maternal recall) IgG-ELISA serologic biomarkers included tetanus...
Many African countries have reported declines in malaria incidence, attributed to the implementation of control strategies. In Mali, artemisinin-based combination therapy (ACT) was introduced 2004, and long-lasting insecticide-treated nets (LLINs) been partially distributed free charge since 2007. Malian town Bandiagara, a study conducted from 2009 2013 showed stable incidence compared with 1999, despite ACTs LLINs. Since 2016, seasonal chemoprevention has scaled up across country. addition...
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens mediate parasite sequestration and host immune evasion. Reactivity to 21 PfEMP1 fragments on a microarray was measured in serum samples from Malian children aged 1–6 years adults. Seroreactivity higher adults than children; intracellular conserved were more widely recognized extracellular hypervariable fragments. Over malaria season, maintained this differential seroreactivity additional This approach has the potential...
Malaria, an infectious disease caused by the parasite Plasmodium falciparum , causes nearly 435,000 deaths annually worldwide. RIFINs and STEVORs are two variant surface antigen families that involved in malaria pathogenesis immune evasion. Recent work has shown a lack of humoral immunity to these proteins is associated with severe vulnerability Malian children. This first study have compared serologic responses children adults settings endemicity examine such before after clinical episode....
Direct venous inoculation of 3.2 × 103 aseptic, purified, cryopreserved, vialed Plasmodium falciparum (Pf) strain NF54 sporozoites, PfSPZ Challenge (NF54), has been used for controlled human malaria infection (CHMI) in the United States, 4 European countries, and 6 African countries. In nonimmune adults, this results 100% rates. We conducted a double-blind, randomized, dose-escalation study to assess infectivity 7G8 clone Pf (PfSPZ [7G8]). Results showed dose-dependent from 43% 8 102 4.8...