A5079865602- Malaria Research and Control
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Mosquito-borne diseases and control
- HIV Research and Treatment
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- vaccines and immunoinformatics approaches
- Vaccine Coverage and Hesitancy
- Lymphoma Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Social Media in Health Education
- Breast Lesions and Carcinomas
- Cardiac Fibrosis and Remodeling
- Urticaria and Related Conditions
- Ethics in Clinical Research
- Pharmacological Effects and Toxicity Studies
- Hepatitis B Virus Studies
- COVID-19 Impact on Reproduction
- Vitamin D Research Studies
- Drug-Induced Adverse Reactions
- Ion Transport and Channel Regulation
- Fungal Infections and Studies
- Viral-associated cancers and disorders
University of Maryland, Baltimore
2019-2024
Hospital for Tropical Diseases
2024
Wake Forest University
2021
Duke University
2016
Vanderbilt University
2014
University of Minnesota
2012
University of Minnesota Rochester
2011
University of Genoa
2008
Baylor College of Medicine
1992
Alleanza Contro il Cancro
1984
<h3>Importance</h3> Racial and ethnic diversity among study participants is associated with improved generalizability of clinical trial results may address inequities in evidence that informs public health strategies. Novel strategies are needed for equitable access recruitment diverse populations. <h3>Objective</h3> To investigate demographic geographical location data 2 remote COVID-19 trials online compare those a contemporaneous clinic-based study. <h3>Design, Setting, Participants</h3>...
Estimating population prevalence and incidence of prior SARS-CoV-2 infection is essential to formulate public health recommendations concerning the COVID-19 pandemic. However, interpreting estimates based on sero-surveillance requires an understanding duration elevated antibodies following infection, especially in large number people with pauci-symptomatic or asymptomatic disease.We examined > 30,000 serology assays for specific IgG IgM acquired longitudinally 11,468 adults between April...
BACKGROUND Mutations in the dystrophin gene produce clinical manifestations of disease heart, brain, and skeletal muscle patients with Duchenne Beckers muscular dystrophy (DMD/BMD). Conduction disturbances heart block contribute to cardiac decompensation these patients, which suggests an important role for dystrophia conduction system. We therefore examined messenger RNA (mRNA) expression protein localization normal human Purkinje fibers. METHODS AND RESULTS Polymerase chain reaction...
During the COVID-19 pandemic, longitudinal serological surveillance was critical to accurately assess cumulative incidence of and monitor population-level immunity among children. We characterized epidemiology North South Carolina children using remote electronic symptom serial at-home antibody testing in 2–17-year-old from April December 2021. estimated accumulation infection-induced antibodies, defined as seropositivity before vaccination. Reported novel symptoms were for seropositive...
Vitamin D increases cathelicidin production, and might alter mortality due to tuberculosis (TB) in human immunodeficiency virus (HIV) coinfection. However, abundant sun exposure, vita min levels be excellent among Ugandans with HIV TB.
Immunity to mosquito salivary proteins could provide protection against multiple mosquito-borne diseases and significantly impact public health. We evaluated the safety immunogenicity of AGS-v PLUS, a peptide vaccine, in healthy adults 18-50 years old.We conducted randomized, double-blind, placebo-controlled Phase 1 study PLUS administered subcutaneously on Days 22 at Center for Vaccine Development Global Health, Baltimore, MD, USA. Participants were block randomized 1:1:1:1:1 two doses...
Monitoring the effectiveness of COVID-19 vaccines against SARS-CoV-2 infections remains important to inform public health responses. Estimation vaccine (VE) serological evidence infection might provide an alternative measure benefit vaccination infection.We estimated mRNA development anti-nucleocapsid antibodies in March-October 2021, during which Delta variant became predominant. Participants were enrolled from four participating healthcare systems United States, and completed electronic...
Controlled human malaria infection (CHMI) is a powerful tool to evaluate the efficacy of vaccines and pharmacologics. Investigators at University Maryland, Baltimore, Center for Vaccine Development (UMB-CVD) pioneered technique in 1970s continue advance frontiers CHMI research. We reviewed records 338 malaria-naive volunteers who underwent UMB-CVD with Plasmodium falciparum from 1971 until 2017. These 387 events, including 60 via intradermal injection or direct venous inoculation (DVI)...
High levels of immunity to SARS-CoV-2 in the community correlate with protection from COVID-19 illness. Measuring antibody seroprevalence and persistence may elucidate level length afforded by vaccination infection within a population. We measured duration detectable anti-spike antibodies following multistate, longitudinal cohort study almost 13,000 adults who completed daily surveys submitted monthly dried blood spots collected at home. Overall, persisted up 284 days follow-up seroreversion...
Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens play a critical role in host immune evasion. Serologic responses to these have been associated with protection from clinical malaria, suggesting that antibodies PfEMP1 may contribute natural immunity. The first N-terminal constitutive domain is the Duffy binding-like alpha (DBL-α) domain, which contains 300 400 base pair region unique each particular protein (the DBL-α “tag”). This tag has used as marker of diversity and...
Abstract Circumsporozoite protein (CSP) coats the Plasmodium falciparum sporozoite surface and is a major malaria subunit vaccine target. We measured epitope-specific reactivity to field-derived CSP haplotypes in serum samples from Malian adults children on custom peptide microarray. Compared children, showed greater antibody responses more variants regions proximal within central repeat region. Children acquired short-lived immunity an epitope region but not itself. This approach has...
This report describes 3 Rwandan children with massive splenomegaly and pancytopenia who underwent splenectomy. Each was diagnosed Epstein-Barr virus–associated lymphoproliferative disorder (EBV LPD) based on lymphocyte morphology, immunophenotype, the results of EBV in situ hybridization studies. The differential diagnosis splenomegaly, a special emphasis sub-Saharan African context, is discussed along associated disorders. These cases serve as call to consider LPD whom common causes have...
Abstract Background Transmission rates after exposure to a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–positive individual within households and healthcare settings varies significantly between studies. Variability in the extent of community SARS-CoV-2 incidence may contribute differences observed rates. Methods We examined risk factors for infection randomized controlled trial hydroxychloroquine as postexposure prophylaxis. Study procedures included standardized...
Cryptococcosis is rare among children, only occurring in about 1% of children with HIV. We report the case a 12-year-old boy disseminated cryptococcosis. He had history recurrent pneumonia. then developed meningeal symptoms and was found to have Cryptococcus neoformans by cerebrospinal fluid bone marrow aspirate culture. treated amphotericin B for 2 weeks (1 mg/kg/day), fluconazole orally 8 (12 mg/kg/day). also received new diagnosis HIV started on antiretroviral therapy after starting...
Abstract Background Malaria is preventable yet causes &gt;600 000 deaths annually. RTS,S, the first marketed malaria vaccine, has modest efficacy, but improvements are needed for eradication. Methods We conducted an open-label, dose escalation phase 1 study of a full-length recombinant circumsporozoite protein vaccine (rCSP) administered with adjuvant glucopyranosyl lipid A–liposome Quillaja saponaria 21 formulation (GLA-LSQ) on days 1, 29, and 85 or 490 to healthy, malaria-naive adults....
We aimed to investigate sociodemographic factors associated with self-reported COVID-19 infection.
Abstract Background With an estimated 249 million cases and 608,000 deaths in 2022 malaria continues to cause substantial morbidity mortality worldwide, mostly children Sub-Saharan Africa due Plasmodium falciparum. Circumsporozoite protein (CSP) coats the surface of P. falciparum sporozoite is target two vaccines approved by World Health Organization (WHO). CSP has three major regions: N-terminus, central repeat region, C-terminus, which contains highly variable T cell epitopes; only a...
Purpose: Hodgkin Lymphoma (HL) can be associated with pleural effusion but its clinical significance is unclear. We performed a retrospective review of patients enrolled in the COG AHOD0031 intermediate risk HL protocol to determine evolution and coexisting factors such as pleural, lung or bone mass, staging, mediastinal bulk, response chemotherapy.
Abstract Objectives The prevalence and incidence of SARS-CoV-2, the virus which causes COVID-19, at any given time remains controversial, is an essential piece in understanding dynamics epidemic. Cross-sectional studies single point testing approaches continue to struggle with appropriate adjustment methods for high false positive rates low settings or negative settings, post-hoc group level does not fully address this issue even population level. Methods In study, we use seroprevalence as...
Abstract Objective We aimed to investigate sociodemographic factors associated with self-reported COVID-19 infection. Methods The study population is a multicenter prospective cohort of adult volunteers recruited from healthcare systems located in the mid-Atlantic and southern United States. Between April 2020 October 2021 participants completed daily online questionnaires about symptoms, exposures, risk behaviors related COVID-19, including self-reports positive SARS CoV-2 detection tests...