A5038604579- Genetic Associations and Epidemiology
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- COVID-19 and Mental Health
- Diabetes Management and Research
- COVID-19 Clinical Research Studies
- Diabetes Management and Education
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Genomics and Phylogenetic Studies
- Medication Adherence and Compliance
- Bioinformatics and Genomic Networks
- Genomics and Rare Diseases
- SARS-CoV-2 detection and testing
- Musculoskeletal pain and rehabilitation
- Respiratory viral infections research
- Bipolar Disorder and Treatment
- Surgical Simulation and Training
- Sleep and related disorders
- Long-Term Effects of COVID-19
- Nutrition, Genetics, and Disease
- Healthcare Operations and Scheduling Optimization
- Machine Learning in Bioinformatics
- COVID-19 Impact on Reproduction
George Washington University
2018-2025
Milken Institute
2023-2024
Community Partners
2021
Eisenhower Medical Center
2021
Virginia Commonwealth University
2014
University of Minnesota
1998-2008
Japanese Foundation For Cancer Research
1998
Importance Youth-onset type 2 diabetes is associated with poor glycemic control and early onset of complications. Identification psychosocial factors needed to inform efficacious interventions. Objective To identify glycated hemoglobin (HbA 1c ) levels in young adults youth-onset diabetes. Design, Setting, Participants For the i Count cohort study, HbA were measured twice (at baseline [T1] at 1 year [T2]) during last years (2017-2019) observational phase multicenter Treatment Options for...
Importance Youth-onset type 2 diabetes is associated with early development of chronic complications. Treatment elevated blood pressure (BP), nephropathy, and dyslipidemia are critical to reduce morbidity. Data needed on adherence BP- lipid-lowering medications in young adults youth-onset diabetes. Objective To assess factors diagnoses hypertension, or dyslipidemia. Design, Setting, Participants This cohort study measured medication 3 monthly unannounced pill counts at time points 1 year...
An operational RNA code relates amino acids to specific structural features located in tRNA acceptor stems. In contrast the universal nature of genetic code, can vary evolution due coadaptations contacts between aminoacyl-tRNA synthetases and stems their cognate substrates. Here we demonstrate that, for class II prolyl-tRNA synthetase (ProRS), functional have occurred going from bacterial human enzyme. Analysis 20 ProRS sequences that cover all three taxonomic domains (bacteria, eucarya,...
We characterize the overall incidence and risk factors for breakthrough infection among fully vaccinated participants in North Carolina COVID-19 Community Research Partnership cohort. Among 15,808 eligible participants, 638 reported a positive SARS-CoV-2 test after vaccination. Factors associated with lower of time-to-event analysis included older age, prior SARS-CovV-2 infection, higher rates face mask use, receipt booster Higher were by BNT162b2 or Ad26.COV2.S compared to mRNA-1273,...
Analysis of prolyl-tRNA synthetase (ProRS) across all three taxonomic domains (Eubacteria, Eucarya, and Archaea) reveals that the sequences are divided into two distinct groups. Recent studies show Escherichia coli ProRS, a member "prokaryotic-like" group, recognizes specific tRNA bases at both acceptor anticodon ends, whereas human "eukaryotic-like" nucleotide primarily in anticodon. The archaeal Methanococcus jannaschii ProRS is eukaryotic-like although its tRNAPro possesses prokaryotic...
Known crystal structures of class II aminoacyl-tRNA synthetases complexed to their cognate tRNAs reveal that critical acceptor stem contacts are made by the variable loop connecting beta-strands motif 2 located within catalytic core synthetases. To identify potential Escherichia coli prolyl-tRNA synthetase (ProRS), an enzyme unknown structure, we performed cysteine-scanning mutagenesis in loop. We identified arginine residue (R144) was essential for tRNA aminoacylation but played no role...
Abstract Importance Real-world data are needed to assess incidence and factors associated with breakthrough SARS-CoV-2 infections following vaccination. Objective Estimate of associations risk using self-reported from a large NC population sample. Design Prospective observational cohort study utilizing daily online survey capture information about COVID-19 symptoms, testing, vaccination status. Setting Six health care systems in North Carolina collected between January 15, 2021 September 24,...
Objective: To identify psychosocial predictors of diabetes self-efficacy (DSE) in the Treatment Options for type 2 Diabetes Adolescents and Youth (TODAY2) cohort, now young adults with youth-onset (T2D). Methods: In this longitudinal study (T1=baseline, T2=1 year), 348 TODAY2 participants completed measures of: self-efficacy, beliefs about medicines, depression anxiety symptoms, distress, attitudes, self-management support, material need insecurities. Multivariable logistic regression models...
We aimed to investigate sociodemographic factors associated with self-reported COVID-19 infection.
We aim to examine the association of sleep duration, quality, late chronotype, and circadian misalignment with glycemic control risk complications in young adults youth-onset type 2 diabetes followed Treatment Options for Type Diabetes Adolescents Youth (TODAY) study. Self-reported timing, were assessed via a modified Pittsburgh Sleep Quality Index (PSQI) questionnaire, chronotype was Morningness-Eveningness Questionnaire (MEQ). examined including loss (defined as hemoglobin A1c ≥8%),...
Abstract Context Dyslipidemia is highly prevalent in youth with type 2 diabetes (T2D), yet the pathogenic components of dyslipidemia T2D are poorly understood. Objective To evaluate genetic determinants lipid traits through a genome-wide association study. Design, Participants, and Main Outcome Measures We genotyped 206 928 variants imputed 17 642 824 1076 (mean age 15.0 ± 2.48 years) from Treatment Options for Type Diabetes Adolescents Youth (TODAY) SEARCH (SEARCH) studies as part Progress...
Youth-onset type 2 diabetes (T2D) is associated with early development of vascular complications. Treatment hypertension and dyslipidemia are critical to reduce morbidity. iCount examined adherence blood pressure (BP) lipid-lowering medications in young adults youth-onset T2D (mean age 26 y, duration 12 BMI 37 kg/m2) hypertension/nephropathy (n=196) or (n=146) during the observational phase Options for Diabetes Adolescents Youth (TODAY)2 study (2017-2019). They were receiving care their...
Abstract Objectives The prevalence and incidence of SARS-CoV-2, the virus which causes COVID-19, at any given time remains controversial, is an essential piece in understanding dynamics epidemic. Cross-sectional studies single point testing approaches continue to struggle with appropriate adjustment methods for high false positive rates low settings or negative settings, post-hoc group level does not fully address this issue even population level. Methods In study, we use seroprevalence as...
Abstract Objective We aimed to investigate sociodemographic factors associated with self-reported COVID-19 infection. Methods The study population is a multicenter prospective cohort of adult volunteers recruited from healthcare systems located in the mid-Atlantic and southern United States. Between April 2020 October 2021 participants completed daily online questionnaires about symptoms, exposures, risk behaviors related COVID-19, including self-reports positive SARS CoV-2 detection tests...
Type 2 diabetes (T2D) in youth is associated with a pro-atherogenic lipid profile characterized by high triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and low high-density (HDL-c). Genome wide association studies (GWAS) adults have discovered more than 100 variants traits, but the of genetic to dyslipidemia T2D remains unknown. Therefore, we genotyped 206,928 imputed 17,642,824 1,076 from Treatment Options for type Adolescents Youth (TODAY) SEARCH Diabetes (SEARCH) as part...
ABSTRACT Hypothesis The prevalence of type 2 diabetes is higher in Latino populations compared with other major ancestry groups. Not only has the population been systematically underrepresented large-scale genetic analyses, but previous studies relied on imputation ungenotyped variants based 1000 Genomes (1000G) reference panel, which results suboptimal capture low-frequency or Latino-enriched variants. NHLBI Trans-Omics for Precision Medicine (TOPMed) panel represents a unique opportunity...
Abstract Background We characterize the incidence and risk factors of SARS-CoV-2 breakthrough infections in NC-CCRP. Cumulative Incidence Breakthrough after Self-reported Symptomatic Test curves (1 minus unadjusted Kaplan–Meier risk), number at each time point for first self-reported symptomatic positive test, starting from full vaccination among participants who reported vaccination. Methods The NC-CCRP is an observational cohort study assessing COVID-19 symptoms, test results, status,...