A5049214171- Obesity, Physical Activity, Diet
- Sleep and related disorders
- Diabetes Management and Research
- Obstructive Sleep Apnea Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Cardiovascular Disease and Adiposity
- Sleep and Wakefulness Research
- Diabetes Management and Education
- Cardiovascular Health and Disease Prevention
- Growth Hormone and Insulin-like Growth Factors
- Neuroscience of respiration and sleep
- Regulation of Appetite and Obesity
- Health and Lifestyle Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Birth, Development, and Health
- Blood Pressure and Hypertension Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet, Metabolism, and Disease
- Heart Rate Variability and Autonomic Control
- Eating Disorders and Behaviors
- Cardiovascular and Diving-Related Complications
- Glycogen Storage Diseases and Myoclonus
- Restless Legs Syndrome Research
- melanin and skin pigmentation
Massachusetts General Hospital
2017-2024
Rhythm (United states)
2024
Jazz Pharmaceuticals (United States)
2024
Harvard University
2017-2022
Boston Children's Hospital
2019-2022
MaineGeneral Medical Center
2021
University of Chicago
2013-2017
SleepMed
2016
Diabetes Australia
2016
Children's Hospital of Philadelphia
2011-2014
Sleep deprivation is associated with increased risk of adult type 2 diabetes mellitus (T2DM). It uncertain whether sleep and/or altered architecture affects glycemic regulation or insulin sensitivity secretion. We hypothesized that in obese adolescents, disturbances would associate glucose and homeostasis.
Obstructive sleep apnoea (OSA) has been inconsistently associated with insulin resistance and adverse metabolic states. We aimed to assess independent contributions of OSA dyslipidaemia in a large paediatric cohort. Habitually snoring children underwent overnight polysomnography, anthropometric measurements fasting laboratory evaluations. Primary outcome measures included insulin, glucose, homeostasis model resistance, lipoproteins disturbance measures. Among 459 aged 5–12 years, obesity was...
Children with obesity and insulin resistance (IR) have decreased adiponectin increased cardiovascular risk. Adiponectin has antiatherogenic effects, but its mechanism is unclear.Our objectives were 1) to compare lipoprotein subclass particles among obese lean adolescents delineate their relationships IR 2) measure between lipoproteins dependence on body mass index (BMI) and/or IR. DESIGN, SETTING, PATIENTS, AND MAIN OUTCOME MEASURES: This was a cross-sectional study of 57 38 pubertal...
Although the American Academy of Sleep Medicine (AASM) mandates that periodic limb movements during sleep (PLMS) be scored on every polysomnogram, and considers a movement index (PLMI) > 5/h abnormal in children, there is lack community-derived data regarding prevalence PLMS no to support this cutoff value. Therefore, aim study was determine sample normal children. Retrospective study. 195 healthy, non-snoring children aged 5-17 years, recruited from community, who underwent polysomnography...
Hypertension is a complication of obstructive sleep apnea (OSA) syndrome in adults. A correlation between OSA and elevated blood pressure (BP) suggested children, but its pathogenesis remains unclear. Our aim was to study the effects on BP sympathetic nervous system activation as measured by serum cortisol urinary catecholamines. We hypothesized that children with would have higher BP, catecholamines, compared controls.We during polysomnography 78 suspected sleep-disordered breathing 18...
OBJECTIVE To assess pregnancy outcomes in young women with youth-onset type 2 diabetes followed the Treatment Options for Type Diabetes Adolescents and Youth (TODAY) study. RESEARCH DESIGN AND METHODS Pregnancy information (outcome any maternal or fetal complications) was obtained from female participants by self-report. Additionally, medical records child’s neonatal course were data abstracted into standardized forms. RESULTS Over a maximum of 15 years, 260 pregnancies reported 141 (aged...
OBJECTIVE To report the prevalence of depression, eating disorder symptoms, and impaired health-related quality life (HRQOL) examine their longitudinal associations with glycemia diabetes complications in young adults youth-onset type 2 diabetes. RESEARCH DESIGN AND METHODS Participants recruited over a 4-year period were enrolled at 15 clinical centers follow-up observational Treatment Options for Type Diabetes Adolescents Youth (TODAY2) study. From 2014–2020, symptoms disorders, HRQOL by...
OBJECTIVE The Rare and Atypical Diabetes Network (RADIANT) will perform a study of individuals and, if deemed informative, their family members with uncharacterized forms diabetes. RESEARCH DESIGN AND METHODS protocol includes genomic (whole-genome [WGS], RNA, mitochondrial sequencing), phenotypic (vital signs, biometric measurements, questionnaires, photography), metabolomics, metabolic assessments. RESULTS Among 122 WGS results 878 enrolled individuals, likely pathogenic variant in known...
Background Obesity and fat distribution patterns [subcutaneous vs. visceral adipose tissue (VAT)] are important predictors of future cardiometabolic risk. As accurate VAT measurement entails imaging, surrogate anthropometric measurements that would be cheaper quicker to obtain highly desirable. Sagittal abdominal diameter (SAD) may better than other measures in adults, but the value SAD predict magnetic resonance imaging (MRI)-determined adolescents different races, sexes, pubertal stages...
1. Dorit Koren, MD, MTR* 2. Lynne L. Levitsky, MD* 1. *Division of Pediatric Endocrinology and Diabetes Center, Department Pediatrics, Massachusetts General Hospital, Boston, MA * Abbreviations: ADA: : American Association DKA: diabetic ketoacidosis FDA: Food Drug Administration FPG: fasting plasma glucose HbA1c: glycohemoglobin IR: insulin resistance LGA: large for gestational age MODY: maturity-onset diabetes youth NAFLD: nonalcoholic fatty liver disease RISE: Restoring...
Insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-1 have been linked to cardiovascular disease (CVD) risk pathophysiology in adults, but there are limited data youth.The aim of the study was examine relationship between IGFBP-1 with traditional non-traditional CVD factors including inflammatory markers body composition an obese pediatric cohort.A cross-sectional study.The carried out at a university children's hospital.Sixty-one non-diabetic adolescents.Fasting IGF-I,...
To evaluate the relationships between adipose tissue distribution, insulin secretion and sensitivity, sleep-disordered breathing, inflammation in obese adolescents. Cross-sectional study of 56 adolescents who underwent anthropometric measures, dual-energy X-ray absorptiometry, overnight polysomnography, oral glucose tolerance test (OGTT) frequently sampled intravenous test. Correlation regression analyses were used to assess adiposity, measures breathing (oxyhemoglobin nadir, SpO2; apnea...