A5019266982- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Balance, Gait, and Falls Prevention
- Cardiovascular Health and Disease Prevention
- Nutrition and Health in Aging
- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- HIV-related health complications and treatments
- COVID-19 and healthcare impacts
- Obesity, Physical Activity, Diet
- Cerebral Palsy and Movement Disorders
- Cardiovascular and exercise physiology
- Diagnosis and Treatment of Venous Diseases
- Nutritional Studies and Diet
- Peripheral Artery Disease Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Intracranial Aneurysms: Treatment and Complications
- Diet and metabolism studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Central Venous Catheters and Hemodialysis
- Musculoskeletal pain and rehabilitation
Geriatric Research Education and Clinical Center
2016-2025
University of Maryland, Baltimore
2016-2025
Baltimore VA Medical Center
2016-2025
VA Maryland Health Care System
2016-2025
Veterans Health Administration
2008-2025
University of Baltimore
2001-2023
Faculty of 1000 (United States)
2023
Galveston College
2023
University of Maryland Medical Center
2001-2021
The University of Texas Health Science Center at San Antonio
2021
Sleep-disordered breathing is a prevalent condition associated with impairment of daytime function and may predispose individuals to metabolic abnormalities independent obesity. The primary objective this study was determine the consequences community prevalence sleep-disordered in mildly obese, but otherwise healthy, individuals. One hundred fifty healthy men, without diabetes or cardiopulmonary disease, were recruited from community. Measurements included polysomnography, multiple sleep...
Risk factors associated with the progression from impaired glucose tolerance (IGT) to NIDDM were examined in data six prospective studies. IGT and defined all studies by World Health Organization (WHO) criteria, baseline risk measured at time of first recognition IGT. The varied size 177 693 participants IGT, included men women followed 2 27 years after Across studies, incidence rate was 57.2/1,000 person-years ranged 35.8/1,000 87.3/1,000 person-years. Although measures fasting 2-h...
The β3-adrenergic receptor is expressed in visceral adipose tissue and thought to contribute the regulation of resting metabolic rate lipolysis.
Reorganization in central motor networks occurs during early recovery from hemiparetic stroke. In chronic stroke survivors, specific rehabilitation therapy can improve upper extremity function.To test the hypothesis that patients who have impairment following stroke, improves arm function is associated with reorganization of cortical networks.A randomized controlled clinical trial conducted a US ambulatory program 21 (median [IQR], 50.3 [34.8-77.3] months after unilateral stroke). Data were...
Background and Purpose— Physical inactivity propagates disability after stroke through physical deconditioning learned nonuse. We investigated whether treadmill aerobic training (T-AEX) is more effective than conventional rehabilitation to improve ambulatory function cardiovascular fitness in patients with chronic stroke. Methods— Sixty-one adults hemiparetic gait ischemic (>6 months) were randomized 6 months (3×/week) progressive T-AEX or a reference program of stretching plus...
ContextHormone administration to elderly individuals can increase lean body mass (LBM) and decrease fat, but interactive effects of growth hormone (GH) sex steroids their influence on strength endurance are unknown.ObjectiveTo evaluate the recombinant human GH and/or composition, strength, endurance, adverse outcomes in aged persons.Design, Setting, ParticipantsA 26-week randomized, double-blind, placebo-controlled parallel-group trial healthy, ambulatory, community-dwelling US women (n =...
<h3>Objective</h3>To compare the efficacy of treadmill exercises and stretching resistance in improving gait speed, strength, fitness for patients with Parkinson disease.<h3>Design</h3>A comparative, prospective, randomized, single-blinded clinical trial 3 types physical exercise.<h3>Setting</h3>The Parkinson's Disease Movement Disorders Center at University Maryland Baltimore Veterans Affairs Medical Center, Geriatric Research Education Clinical Center.<h3>Patients</h3>A total 67 disease...
Age differences in height derived from cross-sectional studies can be the result of differential secular influences among age cohorts. To determine magnitude loss that accompanies aging, longitudinal are required. The authors studied 2,084 men and women aged 17–94 years enrolled 1958 to 1993 Baltimore Longitudinal Study Aging, Baltimore, Maryland. On average, men's was measured nine times during 15 women's five 9 years. rate decrease greater for than men. For both sexes, began at about 30...
Background and Purpose— Stroke often impairs gait thereby reducing mobility fitness promoting chronic disability. Gait is a complex sensorimotor function controlled by integrated cortical, subcortical, spinal networks. The mechanisms of recovery after stroke are not well understood. This study examines the hypothesis that progressive task-repetitive treadmill exercise (T-EX) improves in subjects with hemiparetic inducing adaptations brain (plasticity). Methods— A randomized trial determined...
It has been proposed that the decline in glucose tolerance with age is not a primary aging effect but secondary to combination of other age-associated characteristics, i.e., disease, medication, obesity, central and upper-body fat deposition, inactivity. To test this hypothesis, we first eliminated from analysis Baltimore Longitudinal Study Aging participants identifiable diseases or medications known influence tolerance. Seven hundred forty-three men women, aged 17–92 yr, remained for...
OBJECTIVE: To determine the effects of a 6‐month exercise program on ambulatory function, free‐living daily physical activity, peripheral circulation, and health‐related quality life (QOL) in disabled older patients with intermittent claudication. DESIGN: Prospective, randomized controlled trial. SETTING: University Medical Center Veterans Affairs Center, Baltimore, Maryland. PARTICIPANTS: Thirty‐one 61 Fontaine stage II arterial occlusive disease (PAOD) were to rehabilitation 30 usual‐care...
The effects of a 16-wk strength-training program on total and regional body composition were assessed by dual-energy X-ray absorptiometry (DEXA), magnetic resonance imaging (MRI), hydrodensitometry in 13 untrained healthy men [60 +/- 4 (SD) yr]. Nine additional (62 6 yr) served as inactive controls. resulted substantial increases both upper (39 8%; P < 0.001) lower (42 14%; strength. Total fat-free mass (FFM) increased 2 kg (62.0 7.1 to 64.0 7.2 kg; 0.001), fat decreased the same amount...
Background and Purpose— Although cigarette smoking is known to be a risk factor for ischemic stroke, there are few data on the dose-response relationship between stroke in young ethnically diverse population. Methods— We used from Stroke Prevention Young Women Study, population-based case-control study of factors women aged 15 49 years examine stroke. Historical data, including history, was obtained through standardized interviews. Odds ratios (OR) were estimated using logistic regression....
Although a familial contribution to human longevity is recognized, the nature of this largely unknown. We have examined life span in Old Order Amish (OOA) population Lancaster County, Pennsylvania. Analyses were conducted on 1,655 individuals, representing all those born prior 1890 and appearing most widely available genealogy, surviving until at least age 30 years, with known date death. Mean death (+/-SD) was 70.7 +/- 15.6 did not change appreciably over time. Parental offspring ages...
Background and Purpose. This randomized controlled trial tests the efficacy of bilateral arm training with rhythmic auditory cueing (BATRAC) versus dose-matched therapeutic exercises (DMTEs) on upper-extremity (UE) function in stroke survivors uses functional magnetic resonance imaging (fMRI) to examine effects cortical reorganization. Methods. A total 111 adults chronic UE paresis were 6 weeks (3×/week) BATRAC or DMTE. Primary end points assessments Fugl-Meyer Test (FM) modified Wolf Motor...
Objectives To evaluate the performance of kidney function estimation equations and to determine frequency drug dose discordance in an older population. Design Cross-sectional analysis data from community-dwelling volunteers randomly selected Baltimore Longitudinal Study Aging January 1, 2005, December 31, 2010. Subjects A total 269 men women with a mean ± SD age 81 6 years, serum creatinine concentration (Scr) 1.1 0.4 mg/dl, 24-hour measured clearance (mClcr) 53 13 ml/minute. Measurements...
The coronavirus disease 2019 (COVID-19) pandemic caused disruptions in treatment for cancer. Less is known about its impact on new cancer diagnoses, where delays could cause worsening long-term outcomes. This study quantifies decreases encounters related to prostate, lung, bladder and colorectal cancers, procedures that facilitate their diagnosis, diagnoses of those cancers the COVID era compared pre-COVID era. All at Veterans' Affairs facilities nationwide from 2016 through 2020 were...