A5006245950- Diabetes and associated disorders
- Pancreatic function and diabetes
- Genetic Associations and Epidemiology
- Diabetes Management and Research
- Gestational Diabetes Research and Management
- Diabetes Treatment and Management
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Maternal and fetal healthcare
- Bariatric Surgery and Outcomes
- Bioinformatics and Genomic Networks
- Pregnancy and preeclampsia studies
- Adrenal Hormones and Disorders
- RNA Research and Splicing
- Obesity, Physical Activity, Diet
- Cancer Immunotherapy and Biomarkers
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Maternal and Perinatal Health Interventions
- Nutrition, Genetics, and Disease
- Nuclear Structure and Function
- Birth, Development, and Health
- Hormonal Regulation and Hypertension
- RNA modifications and cancer
- Female Genital Mutilation/Cutting Issues
- Endoplasmic Reticulum Stress and Disease
Broad Institute
2015-2025
Massachusetts General Hospital
2017-2025
Harvard University
2011-2025
University of Pennsylvania
2023
Brigham and Women's Hospital
2015-2020
Harvard–MIT Division of Health Sciences and Technology
2017
George Mason University
2014-2016
Boston Children's Hospital
2011-2014
Princeton University
2011
University of South Florida
2005-2010
A simple biochemical method to isolate mRNAs pulled down with a transfected, biotinylated microRNA was used identify direct target genes of miR-34a, tumor suppressor gene. The reidentified most the known miR-34a regulated expressed in K562 and HCT116 cancer cell lines. Transcripts for 982 were enriched pull-down both Despite this large number, validation experiments suggested that ∼90% identified lines can be directly by miR-34a. Thus is capable regulating hundreds genes. transcripts highly...
Background: Racial inequities for patients with heart failure (HF) have been widely documented. HF who receive cardiology care during a hospital admission better outcomes. It is unknown whether there are differences in to or general medicine service by race. This study examined the relationship between race and service, its effect on 30-day readmission mortality Methods: We performed retrospective cohort from September 2008 November 2017 at single large urban academic referral center of all...
Significance A proportion of the variation in HIV-1 viral load infected population is influenced by host genetics. Using a large sample individuals ( n = 6,315) with genome-wide genotype data, we sought to map genomic regions that influence HIV and quantify their impact. We identified amino acid positions located binding groove class I HLA proteins (HLA-A -B) SNPs chemokine (C-C motif) receptor 5 gene region together explain 14.5% observed load. Controlling for these signals, estimated an...
How students manage their time is critical for academic performance and an important component of self-regulated learning. The purpose the present study was to examine relationships among first-year college students’ ( N = 589) use, self-regulation, target actual grade point average (GPA) at three points. Findings showed that planned spent less on academics than socializing work obligations in first semester. Students generally spend more second Academic use (planned hours) related higher...
Importance Immune checkpoint inhibitors (ICIs) have revolutionized cancer care; however, accompanying immune-related adverse events (irAEs) confer substantial morbidity and occasional mortality. Life-threatening irAEs may require permanent cessation of ICI, even in patients with positive tumor response. Therefore, it is imperative to comprehensively define the spectrum aid individualized decision-making around initiation ICI therapy. Objective To incidence, risk factors, clinical an...
Abstract Type 1 diabetes (T1D) polygenic risk scores (PRS) are effective tools for discriminating T1D from other types and predicting risk, with applications in screening intervention trials. A previously published Genetic Risk Score 2 (GRS2) is widely adopted, but challenges standardization accessibility have hindered broader clinical research utility. To address this, we introduce GRS2x, a standardized cross- compatible method accurate PRS calculation, demonstrating genotyping reference...