Nisha Verma
A5104607855- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- Blood disorders and treatments
- COVID-19 epidemiological studies
- RNA regulation and disease
- NF-κB Signaling Pathways
- Cystic Fibrosis Research Advances
- Cancer Cells and Metastasis
- Breast Cancer Treatment Studies
- Long-Term Effects of COVID-19
- Peroxisome Proliferator-Activated Receptors
- Pulmonary Hypertension Research and Treatments
- Cleft Lip and Palate Research
- Chronic Kidney Disease and Diabetes
- Fractional Differential Equations Solutions
- Burkholderia infections and melioidosis
- Advanced Control Systems Design
- COVID-19 and Mental Health
- COVID-19 impact on air quality
- Radio, Podcasts, and Digital Media
- Mycobacterium research and diagnosis
- Pediatric health and respiratory diseases
- Renal Diseases and Glomerulopathies
The Royal Free Hospital
2013-2023
University College London
2013-2023
Royal Free London NHS Foundation Trust
2014-2022
Armed Forces Medical College
2020-2021
Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
2020
Southern Command Hospital
2020
Background: Rituximab, a chimeric monoclonal antibody against CD20, is increasingly used in the treatment of B-cell lymphomas and autoimmune conditions. Transient peripheral depletion expected following rituximab therapy. Although initial clinical trials did not show significant hypogammaglobulinaemia, reports this are now appearing literature. Methods: We performed retrospective review patients previously treated with that were referred to Clinical Immunology symptomatic or severe...
Vaccination prevents severe morbidity and mortality from COVID-19 in the general population. The immunogenicity efficacy of SARS-CoV-2 vaccines patients with antibody deficiency is poorly understood.
Abstract In March 2020, the United Kingdom Primary Immunodeficiency Network (UKPIN) established a registry of cases to collate outcomes individuals with PID and SID following SARS-CoV-2 infection treatment. A total 310 in or have now been reported UK. The overall mortality within cohort was 17.7% (n = 55/310). Individuals CVID demonstrated an fatality rate (IFR) 18.3% 17/93), receiving IgRT had IFR 16.3% 26/159) SID, 27.2% 25/92). higher inpatient died at younger age than general population....
Background Patients with primary and secondary antibody deficiency are vulnerable to COVID-19 demonstrate diminished responses following two-dose SARS-CoV-2 vaccine schedules. Third vaccinations have been deployed enhance their humoral cellular immunity. Objectives To determine the immunogenicity of third immunisation in a heterogeneous cohort patients deficiency. Methods Participants enrolled COV-AD study were sampled before after dose. Serological determined using ELISA, live-virus...
Most of the currently known heterozygous pathogenic NFKB1 (Nuclear factor kappa B subunit 1) variants comprise deleterious defects such as severe truncations, internal deletions, and frameshift variants. Collectively, these represent most frequent monogenic cause common variable immunodeficiency (CVID) identified so far. encodes transcription precursor p105 which undergoes limited proteasomal processing its C-terminal half to generate mature NF-κB p50. Whereas p105/p50 haploinsufficiency due...
Meningitis, a potentially life threatening illness, requires prompt recognition and treatment. Recurrent meningitis necessitates detailed investigations to identify the underlying cause. We describe two adult patients with recurrent due an skull base abnormality.
Abstract Background Vaccination prevents severe morbidity and mortality from COVID-19 in the general population. The immunogenicity efficacy of SARS-CoV-2 vaccines patients with antibody deficiency is poorly understood. Objectives COVID (COV-AD) a multi-site United Kingdom study that aims to determine immune response infection vaccination primary or secondary deficiency, population suffers recurrent does not respond well vaccination. Methods Individuals on immunoglobulin replacement therapy...
Abstract Background Transmission rates after exposure to a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–positive individual within households and healthcare settings varies significantly between studies. Variability in the extent of community SARS-CoV-2 incidence may contribute differences observed rates. Methods We examined risk factors for infection randomized controlled trial hydroxychloroquine as postexposure prophylaxis. Study procedures included standardized...
Abstract Purpose To define the burden of morbidity and mortality arising from COVID-19 in individuals with primary (PID) secondary immunodeficiency (SID) United Kingdom. Methods In March 2020, Kingdom Primary Immunodeficiency Network (UKPIN) established a registry cases to collate outcomes PID SID following SARS-CoV-2 infection treatment. Anonymised demographic data, pre-SARS-CoV-2 lymphocyte counts, co-morbidities, targeted treatments were collected. Three groups analysed further detail:...
Abstract Background Patients with primary and secondary antibody deficiency are vulnerable to COVID-19 demonstrate diminished responses following two-dose SARS-CoV-2 vaccine schedules. Third vaccinations have been deployed enhance their humoral cellular immunity. Objectives To determine the immunogenicity of third immunisation in a heterogeneous cohort patients deficiency. Methods Participants enrolled COV-AD study were sampled before after dose. Serological determined using ELISA,...
Vitamin B12 deficiency is seen in countries like India mainly because of predominantly vegetarian diet and a significant health problem. Patients present with various neurological hematological manifestations megaloblastic anemia. In this case report, we 14-year-old girl child having history past blood transfusions iron anemia currently presenting severe due to idiopathic autoimmune hemolytic (AIHA) later found have concomitant vitamin deficiency. On investigating, she had deficiency, raised...
<h3>Introduction</h3> Patients with alpha-1 antitrypsin deficiency (AATD) who are homozygous for the mutated Z allele (PiZZ) typically present emphysema and liver cirrhosis, caused by uncontrolled action of neutrophil elastase in lungs toxic gain-of-function AAT polymer aggregates ER hepatocytes. The link between cardiovascular disease COPD is widely accepted, but less well understood AATD. This study aimed to investigate how markers lung function severity rate progression associated risk a...
Introduction: Primary mediastinal non-seminomatous germ cell tumors (NSGCT) have a worse prognosis than gonadal (GCTs). Malignant transformation of teratomatous components GCT to somatic malignancy is rare.
 Materials and methods: A case primary NSGCT with malignant teratoma was seen in 23 years old male. Resected tumor specimen received. Tissue processing done sections were prepared for Histo Pathological Examination.
 Results: Histopathology confirmed yolk sac components....