A5002259373- Malaria Research and Control
- Mosquito-borne diseases and control
- Vector-borne infectious diseases
- Parasite Biology and Host Interactions
- Bird parasitology and diseases
- Viral Infections and Vectors
- Genetic diversity and population structure
- Identification and Quantification in Food
- Invertebrate Immune Response Mechanisms
- Primate Behavior and Ecology
- vaccines and immunoinformatics approaches
- Parasites and Host Interactions
- Helminth infection and control
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Parasitic Infections and Diagnostics
- Livestock and Poultry Management
- Drug-Induced Hepatotoxicity and Protection
- Aquaculture disease management and microbiota
- Enzyme Production and Characterization
- Advanced Cellulose Research Studies
- Vibrio bacteria research studies
- SARS-CoV-2 detection and testing
- Zoonotic diseases and public health
- Venomous Animal Envenomation and Studies
Brazilian Center for Research in Energy and Materials
2025
Universidade de São Paulo
2014-2024
Institute of Biomedical Science
2019-2024
Imperial College London
2021
University of Oxford
2021
Harvard University
2021
Centers for Disease Control and Prevention
2014
The role of zoos in conservation programmes has increased significantly last decades, and the health captive animals is essential to guarantee success such programmes. However, zoo birds suffer from parasitic infections, which often are caused by malaria parasites related haemosporidians. Studies determining occurrence diversity these parasites, aiming better understanding infection influence on fitness birds, limited. In 2011–2015, prevalence Plasmodium spp. Haemoproteus was examined blood...
We examined the mitogenomes of a large global collection human malaria parasites to explore how and when Plasmodium falciparum P. vivax entered Americas. found evidence significant contribution African South Asian lineages present-day New World with additional appearing originate from Melanesia that were putatively carried by Australasian peoples who contributed genes Native Americans. Importantly, mitochondrial vivax-like species simium are shared platyrrhine monkeys humans in Atlantic...
Plasmodium vivax is the geographically most widespread human malaria parasite. To analyze patterns of microsatellite diversity and population structure across countries different transmission intensity, genotyping data from 11 markers was either generated or compiled 841 isolates four continents collected in 1999–2008. Diversity highest South-East Asia (mean allelic richness 10.0–12.8), intermediate South Pacific (8.1–9.9) Madagascar Sudan (7.9–8.4), lowest America Central (5.5–7.2). A...
Plasmodium falciparum (Pf) whole-organism sporozoite vaccines have been shown to provide significant protection against controlled human malaria infection (CHMI) in clinical trials. Initial CHMI studies showed significantly higher durable homologous than heterologous strains, suggesting the presence of strain-specific vaccine-induced protection. However, interpretation these results and understanding their relevance vaccine efficacy hampered by lack knowledge on genetic differences between...
The Americas were the last continent colonized by humans carrying malaria parasites. Plasmodium falciparum from New World shows very little genetic diversity and greater linkage disequilibrium, compared with its African counterparts, is clearly subdivided into local, highly divergent populations. However, limited available data have revealed extensive in American populations of another major human parasite, P. vivax.We used an improved sample preparation strategy next-generation sequencing...
Malarial infections are often missed by microscopy, and most parasite carriers asymptomatic in low-endemicity settings. Whether detectability its ability to elicit symptoms change as transmission declines remains unclear.
The breakdown of cellulose is one the most important reactions in nature1,2 and central to biomass conversion fuels chemicals3. However, microfibrillar organization its complex interactions with other components plant cell wall poses a major challenge for enzymatic conversion4. Here, by mining metagenomic 'dark matter' (unclassified DNA unknown function) microbial community specialized lignocellulose degradation, we discovered metalloenzyme that oxidatively cleaves cellulose. This acts on...
The transmission of malaria in the extra-Amazonian regions Brazil, although interrupted 1960s, has persisted to present time some areas dense Atlantic Forest, with reports cases characterized by particular cycles and clinical presentations. Bromeliad-malaria, as it is named, particularly frequent state Espírito Santo, Plasmodium vivax being parasite commonly recognized aetiologic agent human infections. With regard spatial temporal distances between reported this region, cycle does not fit...
Emerging Plasmodium vivax resistance to chloroquine (CQ) may undermine malaria elimination efforts in South America. CQ-resistant P. has been found the major port city of Manaus but not main hot spots across Amazon Basin Brazil, where CQ is routinely coadministered with primaquine (PQ) for radical cure malaria.
The population history of Plasmodium simium, which causes malaria in sylvatic Neotropical monkeys and humans along the Atlantic Coast Brazil, remains disputed. Genetically diverse P vivax populations from various sources, including lineages that founded species are thought to have arrived Americas separate migratory waves.We use genomic approaches investigate origin evolution simium.We find a minimal genome-level differentiation between simium present-day New World isolates, consistent with...
Although the geographic origin of malaria cases imported into United States can often be inferred from travel histories, these histories may lacking or incomplete. We hypothesized that mitochondrial haplotypes could provide region-specific molecular barcodes for tracing Plasmodium vivax infections. An analysis 348 genomes worldwide parasites and new sequences 69 diagnosed across allowed a assignment most infections originating Americas, southeast Asia, east Melanesia. However, lineages...
Malaria in the Amazon is often perceived as an exclusively rural disease, but transmission has been increasingly documented within and near urban centers. Here we explore patterns causes of urban-to-rural mobility, which places travelers at risk malaria Mâncio Lima, main hotspot northwestern Brazil. We also analyze rural-to-urban mobility caused by treatment seeking, poses additional infection to residents. show that localities most frequently visited residents–typically farming settlements...
Abstract Background Immunity after dengue virus (DENV) infection has been suggested to cross-protect from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and mortality. Methods We tested whether serologically proven prior DENV diagnosed in September–October 2019, before the disease 2019 (COVID-19) pandemic, reduced risk of SARS-CoV-2 clinically apparent COVID-19 over next 13 months a population-based cohort Amazonian Brazil. Mixed-effects multiple logistic regression analysis...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Gamma variant has been hypothesized to cause more illness than previous variants, especially in children. Successive SARS-CoV-2 IgG serosurveys the Brazilian Amazon showed that age-specific attack rates and proportions of symptomatic infections were similar before after emergence.
Background Plasmodium vivax is a neglected human malaria parasite that causes significant morbidity in the Americas, Middle East, Asia, and Western Pacific. Population genomic approaches remain little explored to map local regional transmission pathways of P. across main endemic sites where great progress has been made towards elimination over past decades. Methodology/Principal findings We analyze 38 patient-derived genome sequences from Mâncio Lima (ML)–the Amazonian hotspot next...
ABSTRACT. The 1990s saw the rapid reemergence of malaria in Amazonia, where it remains an important public health priority South America. Amazonian International Center Excellence Malaria Research (ICEMR) was designed to take a multidisciplinary approach toward identifying novel control and elimination strategies. Based on geographically epidemiologically distinct sites Northeastern Peruvian Western Brazilian Amazon regions, synergistic projects integrate epidemiology, vector biology,...
We evaluated the clinical efficacy of artesunate-mefloquine (ASMQ) fixed-dose combination to treat uncomplicated malaria in Juruá Valley, main Plasmodium falciparum transmission hotspot Brazil. Between November 2010 and February 2013, we enrolled 162 patients aged 4-73 years, with fever or a history fever, single-species P. infection confirmed by microscopy polymerase chain reaction (PCR). All 154 who completed 42-day follow-up presented an adequate parasitologic response. ASMQ was well...
Abstract Background Larvicides are typically applied to fixed and findable mosquito breeding sites, such as fish farming ponds used in commercial aquaculture, kill immature forms thereby reduce the size of adult malaria vector populations. However, there is little evidence suggesting that larviciding may suppress community-wide transmission outside Africa. Here, we tested whether biological larvicide VectoMax FG at monthly intervals can incidence Amazonian Brazil. Methods This study was...
Abstract The relative contribution of imported vs. locally acquired infections to urban malaria burden remains largely unexplored in Latin America, the most urbanised region developing world. Here we use a simple molecular epidemiology framework examine transmission dynamics Plasmodium vivax Mâncio Lima, Amazonian municipality with highest incidence rate Brazil. We prospectively genotyped 177 P. diagnosed residents between June 2014 and July 2015 showed that local parasites are structured...
This population-based open cohort study aims to investigate biological and sociodemographic drivers of malaria transmission in the main urban hotspot Amazonian Brazil.
Malaria remains common among native Amazonians, challenging Brazil's elimination efforts.We examined the epidemiology of malaria in riverine populations country's main hotspot - upper Juruá Valley Acre state, close to Brazil-Peru border, where Plasmodium vivax accounts for > 80% cases.Participants (n = 262) from 10 villages along Azul River were screened parasites by microscopy and genus-specific, cytochrome b (cytb) gene-based polymerase chain reaction. Positive samples further tested with...