A5081347909- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Hepatitis C virus research
- Viral Infections and Vectors
- Multiple Myeloma Research and Treatments
- Drug Transport and Resistance Mechanisms
Université des Sciences, des Techniques et des Technologies de Bamako
2022-2024
National Institute of Malaria Research
2024
Plasmodium parasites caused 241 million cases of malaria and over 600,000 deaths in 2020. Both P. falciparum ovale are endemic to Mali cause clinical malaria, with infections typically being more severe. Here, we sequenced RNA from nine pediatric blood samples collected during either or ovale, characterized the host parasite gene expression profiles. We found that human varies between individuals than according species causing infection, while profiles cluster by species. Additionally, DNA...
Abstract In Bandiagara, Mali, children experience on average two clinical malaria episodes per year. However, even in the same transmission area, number of uncomplicated symptomatic infections, and their parasitemia, can vary dramatically among children. We simultaneously characterize host parasite gene expression profiles from 136 Malian with falciparum examine differences relative proportion immune cells stages, as well expression, associated infection or patient characteristics....
Plasmodium parasites caused over 600,000 deaths in 2022. In Mali, P. falciparum is responsible for the majority of malaria cases and transmitted seasonally. Anti-malarial immunity develops slowly repeated exposures to but some aspects this (e.g., antibody titers) wane during non-transmission, dry season. Here, we sequenced RNA from 33 pediatric blood samples collected infections at beginning or end a transmission season characterized host parasite gene expression profiles paired, consecutive...
ABSTRACT Plasmodium parasites, the causative organism of malaria, caused over 600,000 deaths in 2022. In Mali, falciparum causes majority malaria cases and is transmitted seasonally. Anti-malarial immunity develops slowly repeated exposures to P. some aspects this (e.g., antibody titers) wane during non-transmission, dry season. Here, we sequenced RNA from 33 pediatric blood samples collected infections at beginning or end a transmission season, characterized host parasite gene expression...
Abstract In Bandiagara, Mali, children experience on average two clinical malaria episodes per season. However, even in the same transmission area, number of uncomplicated symptomatic infections, and their parasitemia, vary dramatically among children. To examine factors contributing to these variations, we simultaneously characterized host parasite gene expression profiles from 136 with falciparum analyzed 9,205 human 2,484 Plasmodium genes. We used deconvolution estimate relative...
Abstract In Bandiagara, Mali, children experience on average two clinical malaria episodes per season. However, even in the same transmission area, number of uncomplicated symptomatic infections, and their parasitemia, vary dramatically among children. To examine factors contributing to these variations, we simultaneously characterized host parasite gene expression profiles from 136 with falciparum analyzed 9,205 human 2,484 Plasmodium genes. We used deconvolution estimate relative...
Abstract Plasmodium parasites caused 241 million cases of malaria and over 600,000 deaths in 2020. Both P. falciparum ovale are endemic to Mali cause illness, with infections typically being more severe. Here, we sequenced RNA from nine pediatric blood samples collected during uncomplicated, symptomatic either or characterized the host parasite gene expression profiles. We found that human varies between individuals than according species causing infection, while profiles cluster by species....