A5013545541- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- Bioactive Natural Diterpenoids Research
- Ion channel regulation and function
- Biochemical and Structural Characterization
- Marine Invertebrate Physiology and Ecology
- Essential Oils and Antimicrobial Activity
- Lipoproteins and Cardiovascular Health
- Ginger and Zingiberaceae research
- Lipid Membrane Structure and Behavior
- Healthcare Regulation
- Healthcare and Venom Research
- Cancer, Lipids, and Metabolism
- Youth, Drugs, and Violence
- Inflammasome and immune disorders
- Public Health in Brazil
- Plant Toxicity and Pharmacological Properties
- Traditional and Medicinal Uses of Annonaceae
- Vitamin K Research Studies
- Pomegranate: compositions and health benefits
- Toxoplasma gondii Research Studies
- Phytochemicals and Medicinal Plants
- Rural and Ethnic Education
- Healthcare during COVID-19 Pandemic
- Animal Nutrition and Physiology
Universidade Federal de Uberlândia
2013-2024
SUPERA Park of Innovation and Technology of Ribeirão Preto
2011
Universidade de São Paulo
2007
Phospholipases A2 (PLA2) are enzymes of high medical scientific interest due to their involvement in a large number human inflammatory diseases. PLA2 constitute diverse family which catalyses the hydrolysis sn-2 ester bond glycerophospholipids and exhibit wide range physiological pathological effects. The ubiquitous nature highlights important role they play many biological processes, as cell signaling growth, including generation proinflammatory lipid mediators such prostaglandin...
SUMMARY This paper reports the effects of BnSP-7 toxin, a catalytically inactive phospholipase A 2 from Bothrops pauloensis snake venom, on Leishmania ( ) amazonensis . presented activity against promastigote parasite forms both in MTT assay, with IC 50 58·7 μ g mL −1 and growth curve, inhibiting proliferation 60–70% at concentrations 50–200 toxin 96 h after treatment. Also, amastigotes, reducing viability by 50% 28·1 delaying amastigote–promastigote differentiation process. Ultrastructural...
The development of cardiovascular diseases with atherosclerotic origin is associated a severe inflammatory process. Neutrophils and lymphocytes are cells sensitive to this type disorder their ratio, known as the NLR (neutrophil/lymphocyte ratio), has shown be useful in clinical practice. aim study was assess role disease risk assessment. We carried out literature review PubMed databases searching for articles published between 2001 2017 found that fact marker disease. Using patients at would...
Abstract Many medicinal plants have been recommended for the treatment of snakebites. The aqueous extracts prepared from leaves Schizolobium parahyba (a plant found in Mata Atlantica Southeastern Brazil) were assayed their ability to inhibit some enzymatic and biological activities induced by Bothrops pauloensis Crotalus durissus terrificus venoms as well isolated toxins neuwiedase (metalloproteinase), BnSP‐7 (basic Lys49 PLA 2 ) CB (PLA crotoxin complex). Phospholipase A , coagulant,...
The effect of an L-amino acid oxidase isolated from Bothrops pirajai snake venom (BpirLAAO-I) was investigated on infection Toxoplasma gondii in human foreskin fibroblasts (HFF). cytotoxic activity BpirLAAO-I HFF cells showed a dose-dependent toxicity with median dose (TD50) 11.8 µg/mL. induced considerable decrease the T. index under two different conditions, treatment tachyzoites before or after infection. A maximal inhibition (56%) found for infection, inhibitory (ID50) at 1.83 µg/mL and...
Abstract The herbal extract of Schizolobium parahyba leaves is used commonly in the Brazil central region to treat snakebites. This study evaluates acute toxicological effects aqueous mice 24 h after intraperitoneal administration. Acute toxicity was evaluated using biochemical, hematological and histopathological assays. Alterations levels transaminases, bilirubin, albumin prothrombrin time were observed, these are likely occur due hepatic injury, which confirmed by light microscopy. Liver...
Summary Ophidic accidents are among the problems of public health in Brazil. The components from bothropic venom responsible for many systemic clinical complications resulting envenomation. present work aimed to analyse changes induced mice after intraperitoneal administration Bmoo TX ‐I, a myotoxic acidic phospholipase A 2 isolated Bothrops moojeni venom. Urinalysis was performed and following plasma biochemical markers were documented: urea, creatinine uric acid (renal function); glucose...
Type II diabetes is a chronic non-communicable disease characterized as public health problem. investigate the presence of chemical parameters in urine diabetic individuals and correlate with anthropometric measurements. This cross-sectional descriptive study carried out 50 volunteers, developed from answer to some questions, analysis measurement Metformin main drug for treatment, average age height; 60.4 years 163.5 cm, median weight duration; 74kg 54 months respectively measurements ranged...