A5038623349- Venomous Animal Envenomation and Studies
- Biochemical and Structural Characterization
- Ion channel regulation and function
- Healthcare and Venom Research
- Nicotinic Acetylcholine Receptors Study
- Rabies epidemiology and control
- Research on Leishmaniasis Studies
- Cellular transport and secretion
- Trypanosoma species research and implications
- Insect and Pesticide Research
- Synthesis and Biological Evaluation
- Toxin Mechanisms and Immunotoxins
- Mitochondrial Function and Pathology
- Enzyme Production and Characterization
- Glycosylation and Glycoproteins Research
- Marine Invertebrate Physiology and Ecology
- Crystallization and Solubility Studies
- Biochemical Acid Research Studies
- Marine Sponges and Natural Products
- Entomopathogenic Microorganisms in Pest Control
- Metabolism and Genetic Disorders
- Science and Education Research
- Parasites and Host Interactions
- Italian Social Issues and Migration
- Connexins and lens biology
Universidade de São Paulo
2014-2025
Liverpool School of Tropical Medicine
2023-2025
Universidade de Ribeirão Preto
2016-2022
KU Leuven
2020
Universidade Vila Velha
2020
Instituto de Ciências Farmacêuticas
2020
SUPERA Park of Innovation and Technology of Ribeirão Preto
2019
Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these frequently low affinity challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the discovery of allostery (MIDAS) identify such interactions. Analysis 33 enzymes from human carbohydrate metabolism identified 830 interactions, including known regulators, substrates, products as well previously unreported...
Snakebite envenoming remains a devastating and neglected tropical disease, claiming over 100,000 lives annually causing severe complications long-lasting disabilities for many more1,2. Three-finger toxins (3FTx) are highly toxic components of elapid snake venoms that can cause diverse pathologies, including tissue damage3 inhibition nicotinic acetylcholine receptors, resulting in life-threatening neurotoxicity4. At present, the only available treatments snakebites consist polyclonal...
A series of 28 compounds, 3-nitro-1
<title>Abstract</title> Snakebite envenoming remains a devastating and neglected tropical disease, claiming over 100,000 lives annually causing severe complications long-lasting disabilities for many more<sup>1,2</sup>. Three-finger toxins (3FTx) are highly toxic components of elapid snake venoms that can cause diverse pathologies, including tissue damage<sup>3</sup> inhibition nicotinic acetylcholine receptors (nAChRs) resulting in life-threatening neurotoxicity<sup>4</sup>. Currently, the...
Abstract Metabolism is highly interconnected and also has profound effects on other cellular processes. However, the interactions between metabolites proteins that mediate this connectivity are frequently low affinity difficult to discover, hampering our understanding of important area biochemistry. Therefore, we developed MIDAS platform, which can identify protein-metabolite with great sensitivity. We analyzed 33 enzymes from central carbon metabolism identified 830 were mostly novel, but...
In recent decades, snake venom disintegrins have received special attention due to their potential use in anticancer therapy. Disintegrins are small and cysteine-rich proteins present venoms can interact with specific integrins inhibit activities cell-cell cell-ECM interactions. These molecules, known platelet aggregation, also capable of interacting certain cancer-related integrins, may interfere important processes involved carcinogenesis. Therefore, disintegrin from Crotalus durissus...
Recentes estudos demonstraram que afidicolina, metabólito secundário do fungo endofítico Nigrospora sphaerica, apresenta alta atividade contra o protozoário Leishmania major.Apesar promissor potencial leishmanicida, a afidicolina propriedades físico-químicas e perfil farmacocinético inadequado para terapêutica.Neste sentido, uma revisão da literatura as limitadas modificações este terpeno ainda traz informações sobre moleculares dos compostos já descritos sua correlação com...
Snakebite envenoming can be a life-threatening medical emergency that requires prompt intervention to neutralise the effects of venom toxins. Each year up 138,000 people die from snakebite and 3-fold more victims suffer life-altering disabilities. Current treatment relies solely on antivenom – polyclonal antibodies isolated plasma hyperimmunised animals which is associated with numerous deficiencies. The ADDovenom project seeks deliver novel therapy, through use an innovative protein-based...
In the Atlantic forest of North and Northeast regions Brazil, local population often uses fruit juice aqueous extract leaves soursop (Annona muricata L.) to treat Lachesis muta rhombeata envenomation. Envenomation is a relevant health issue in these areas, especially due its severity because production distribution antivenom limited regions. The aim present study was evaluate relevance use leaf against envenomation by rhombeata.We evaluated biochemical, hematological hemostatic parameters,...
In Brazil, accidents with venomous animals are considered a public health problem. Tityus serrulatus (Ts), popularly known as the yellow scorpion, is most frequently responsible for severe in country. Ts envenoming can cause several signs and symptoms classified according to their clinical manifestations mild, moderate or severe. Furthermore, victims usually present biochemical alterations, including hyperglycemia. Nevertheless, its induced hyperglycemia were never studied documented patient...
Snakebite envenoming can be a life-threatening medical emergency that requires prompt intervention to neutralise the effects of venom toxins. Each year up 138,000 people die from snakebites and threefold more victims suffer life-altering disabilities. The current treatment snakebite relies solely on antivenom-polyclonal antibodies isolated plasma hyperimmunised animals-which is associated with numerous deficiencies. ADDovenom project seeks deliver novel therapy, through use an innovative...