Aaron Leifer
ORCID:
0000-0002-1005-7604
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About
Contact & Profiles
A5069518974
Research Areas
- Mitochondrial Function and Pathology
- Biochemical Acid Research Studies
- Microbial Metabolic Engineering and Bioproduction
University of Utah
2023
Kevin G. Hicks
Ahmad A. Cluntun
Heidi Schubert
Sean R. Hackett
Jordan A. Berg
and 41
more
Paul G. Leonard
Mariana A. Ajalla Aleixo
Youjia Zhou
Alex J. Bott
Sonia R. Salvatore
Fei Chang
Aubrie Blevins
Paige Barta
Samantha Tilley
Aaron Leifer
Andrea Guzman
Ajak Arok
Sarah Fogarty
Jacob M. Winter
Hee‐Chul Ahn
Karen N. Allen
Samuel Block
Iara Aimê Cardoso
Jianping Ding
Ingrid Dreveny
William C. Gasper
Quinn Ho
Atsushi Matsuura
Michael J. Palladino
Sabin Prajapati
Pengkai Sun
Kai Tittmann
Dean R. Tolan
Judith E. Unterlass
Andrew P. VanDemark
Matthew G. Vander Heiden
Bradley A. Webb
Cai‐Hong Yun
Pengkai Zhao
Bei Wang
Francisco J. Schöpfer
Christopher P. Hill
Maria Cristina Nonato
Florian L. Müller
James E. Cox
Jared Rutter
Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these frequently low affinity challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the discovery of allostery (MIDAS) identify such interactions. Analysis 33 enzymes from human carbohydrate metabolism identified 830 interactions, including known regulators, substrates, products as well previously unreported...
10.1126/science.abm3452
article
EN
Science
2023-03-10
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