A5019854695- Parasitic infections in humans and animals
- Congenital Anomalies and Fetal Surgery
- Parasitic Infections and Diagnostics
- Parasite Biology and Host Interactions
- Parasites and Host Interactions
- Helminth infection and control
- Toxoplasma gondii Research Studies
- Animal Disease Management and Epidemiology
- Amoebic Infections and Treatments
- Influenza Virus Research Studies
- Urological Disorders and Treatments
- Viral gastroenteritis research and epidemiology
- Bird parasitology and diseases
- Cerebrospinal fluid and hydrocephalus
- Coccidia and coccidiosis research
- Climate Change, Adaptation, Migration
- Polyomavirus and related diseases
- Forensic Entomology and Diptera Studies
- Virology and Viral Diseases
- Study of Mite Species
- Rabies epidemiology and control
- Viral Infections and Vectors
- Dermatological diseases and infestations
- Vector-Borne Animal Diseases
- Parasitic Diseases Research and Treatment
National University of San Marcos
2015-2024
Universidad Peruana Cayetano Heredia
2009-2024
Johns Hopkins University
2007-2021
Colombian Association of Surgery
2021
Center for Global Health
2010-2020
Oregon Health & Science University
2020
Duke University
2020
Portland State University
2020
University of Pittsburgh
2019
Universidad Mayor
2005-2017
Neurocysticercosis is the main cause of adult-onset seizures in developing world. Whether therapy with antiparasitic agents results improved seizure control has been questioned because lack adequate, controlled studies.We conducted a double-blind, placebo-controlled trial which 120 patients who had living cysticerci brain and treated antiepileptic drugs were randomly assigned to receive either 800 mg albendazole per day 6 dexamethasone for 10 days (60 patients) or two placebos patients). The...
<b>Background: </b> Neurocysticercosis (NCC) is the commonest helminthic CNS infection and main cause of adult-onset seizures in developing countries, also frequent industrialized countries because immigration from endemic zones. Although NCC commonly seen individuals with areas, its role as a epilepsy has been questioned on basis poor methodology published studies. <b>Objective: To determine, cysticercosis-endemic area northern Peruvian coast, frequency 1) epileptic seizures, 2) serum...
Cysticercosis contributes to higher epilepsy rates in developing countries than industrialized ones, yet no estimate exists for the associated burden of disease. We used epidemiological data on neurocysticercosis Peru calculate disease and applied our model other Latin America where is endemic determine a regional estimate. Analysis 12 population-based community studies demonstrated that was highland areas high jungles, with seroprevalences from 6% 24%. In one community, adult seizure...
Background Institutional tuberculosis (TB) transmission is an important public health problem highlighted by the HIV/AIDS pandemic and emergence of multidrug- extensively drug-resistant TB. Effective TB infection control measures are urgently needed. We evaluated efficacy upper-room ultraviolet (UV) lights negative air ionization for preventing airborne using a guinea pig air-sampling model to measure infectiousness ward air. Methods Findings For 535 consecutive days, exhaust from HIV-TB in...
"Prevalence and Comparison of Serologic Assays, Necropsy, Tongue Examination for the Diagnosis Porcine Cysticercosis in Peru" published on Aug 1990 by The American Society Tropical Medicine Hygiene.
Summary: Purpose: To determine the prevalence of epilepsy and role neurocysticercosis in occurrence Atahualpa. Methods: We used a door‐to‐door survey to detect subjects with epileptic seizures, collect blood sample for determination anticysticercal antibodies, evaluate social characteristics population, including household pig ownership. Neurologists examined suspected cases negative individuals. Then patients epilepsy, as well age‐ sex‐matched controls, underwent head computed tomography...
The current understanding of airborne tuberculosis (TB) transmission is based on classic 1950s studies in which guinea pigs were exposed to air from a ward. Recently we recreated this model Lima, Perú, and paper report the use molecular fingerprinting investigate patient infectiousness era HIV infection multidrug-resistant (MDR) TB.
Taeniasis and cysticercosis are major causes of seizures epilepsy. Infection by the causative parasite Taenia solium requires transmission between humans pigs. The disease is considered to be eradicable, but data on attempts at regional elimination lacking. We conducted a three-phase control program in Tumbes, Peru, determine whether would feasible.
The prevalence of epilepsy added to inadequate treatment results in chronic morbidity and considerable mortality poor populations. Neurocysticercosis (NCC), a helminthic disease the central nervous system, is leading cause seizures most world.Taking advantage cysticercosis elimination program, we performed two community-based cross-sectional studies between 2006 2007 58 rural communities (population 20,610) assess characteristics epileptic this endemic region. Serological computed tomography...
The prevalence and characteristics of human taeniasis/cysticercosis porcine cysticercosis were assessed in an endemic area the Peruvian highlands. Individuals from 10 communities had stool examinations (N = 2,951) serologic testing for Taenia solium antibodies 2,583). total population present 703) was also examined by serology. Cysticercosis is hyperendemic this associated with important number seizure cases. Human seroprevalence village ranged 7.1-26.9% (mean, 13.9%). Seroprevalence higher...
Taenia solium taeniasis/cysticercosis is a zoonotic disease complex in which the pig an obligate intermediate host. The infection widespread, particularly developing world, and neurocysticercosis major cause of human neurologic where parasite endemic. Despite easy availability, effective anti-parasitic drugs have not been deployed effectively to control transmission. We investigated vaccine strategy prevent Such would interrupt parasite’s life cycle eliminate source for humans. Two...
Background.Nosocomial transmission of tuberculosis remains an important public health problem. We created in vivo air sampling model to study airborne from patients coinfected with human immunodeficiency virus (HIV) and evaluate environmental control measures.
Neurocysticercosis (NCC) is a frequent cause of epilepsy worldwide. Compared with the more common parenchymal brain cysts, extraparenchymal infections are difficult to manage and have poor prognosis. Serological assays used detect circulating Taenia solium antigens or anti-T. antibodies in serum cerebrospinal fluid (CSF) samples. There no guidelines on whether use CSF specimens for particular assay.We obtained paired samples from 91 patients NCC (48 had intraparenchymal NCC, 43 NCC)...
Background Neurocysticercosis accounts for 30%–50% of all late-onset epilepsy in endemic countries. We assessed the clustering patterns Taenia solium human cysticercosis seropositivity and seizures around tapeworm carriers seven rural communities Peru. Methodology The presence T. solium–specific antibodies was defined as one or more positive bands enzyme-linked immunoelectrotransfer blot (EITB). Neurocysticercosis-related cases were diagnosed clinically had neuroimaging EITB. Principal...
To determine the frequency of spinal neurocysticercosis (NCC) in patients with basal subarachnoid NCC compared that individuals viable limited intraparenchymal (≤20 live cysts brain).We performed a prospective observational case-control study involving cisterns or only NCC. All underwent MRI examinations brain and entire cord to assess involvement.Twenty-seven NCC, 28 were included study. Spinal involvement was found 17 one patient (odds ratio 40.18, 95% confidence interval 4.74-340.31; p <...
Background. The efficacy of current antiparasitic treatment for cerebral Taenia solium cysticercosis with either albendazole (ABZ) or praziquantel (PZQ) is suboptimal. A recent study demonstrated that combining these 2 drugs improves efficacy. We present here the parasiticidal data obtained during a previous phase II pharmacokinetic compared combined ABZ plus PZQ alone. Methods. was randomized, double-blinded, placebo-controlled evaluation pharmacokinetics (15 mg/k/d, 10 days) and (50 in...