A5001998738- Parasitic infections in humans and animals
- Congenital Anomalies and Fetal Surgery
- Parasitic Infections and Diagnostics
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Parasite Biology and Host Interactions
- Parasites and Host Interactions
- Urological Disorders and Treatments
- Insect symbiosis and bacterial influences
- Amoebic Infections and Treatments
- Cardiomyopathy and Myosin Studies
- Cerebrospinal fluid and hydrocephalus
- Synthesis and Biological Evaluation
- Viral Infections and Immunology Research
- Toxoplasma gondii Research Studies
- Bartonella species infections research
- Parasitic Diseases Research and Treatment
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Food Security and Health in Diverse Populations
- Viral gastroenteritis research and epidemiology
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- Diphtheria, Corynebacterium, and Tetanus
- Helicobacter pylori-related gastroenterology studies
Universidad Peruana Cayetano Heredia
2015-2024
Prisma
1996-2024
Cellular Research (United States)
2018
Johns Hopkins University
1992-2017
Michigan Medicine
2017
National University of San Marcos
1999-2016
University of California, San Francisco
2016
Centers for Disease Control and Prevention
1999-2009
Fogarty International Center
2009
The University of Melbourne
2006
Cysticercosis contributes to higher epilepsy rates in developing countries than industrialized ones, yet no estimate exists for the associated burden of disease. We used epidemiological data on neurocysticercosis Peru calculate disease and applied our model other Latin America where is endemic determine a regional estimate. Analysis 12 population-based community studies demonstrated that was highland areas high jungles, with seroprevalences from 6% 24%. In one community, adult seizure...
"Prevalence and Comparison of Serologic Assays, Necropsy, Tongue Examination for the Diagnosis Porcine Cysticercosis in Peru" published on Aug 1990 by The American Society Tropical Medicine Hygiene.
Background. Human noroviruses are among the most common enteropathogens globally, and a leading cause of infant diarrhea in developing countries. However, data measuring impact norovirus at community level sparse. Methods. We followed birth cohort children to estimate infection incidence Peruvian community. Stool samples from diarrheal episodes randomly selected nondiarrheal were tested by polymerase chain reaction for genogroup genotype. Excretion duration rotavirus coinfection evaluated...
We conducted a study of congenital Trypanosoma cruzi infection in Santa Cruz, Bolivia. Our objective was to apply new tools identify weak points current screening algorithms, and find ways improve them.Women presenting for delivery were screened by rapid conventional serological tests. For infants infected mothers, blood specimens obtained on days 0, 7, 21, 30, 90, 180, 270 concentrated examined microscopically; tests performed the day specimens. Maternal infant specimens, including...
The prevalence and characteristics of human taeniasis/cysticercosis porcine cysticercosis were assessed in an endemic area the Peruvian highlands. Individuals from 10 communities had stool examinations (N = 2,951) serologic testing for Taenia solium antibodies 2,583). total population present 703) was also examined by serology. Cysticercosis is hyperendemic this associated with important number seizure cases. Human seroprevalence village ranged 7.1-26.9% (mean, 13.9%). Seroprevalence higher...
Taenia solium taeniasis/cysticercosis is a zoonotic disease complex in which the pig an obligate intermediate host. The infection widespread, particularly developing world, and neurocysticercosis major cause of human neurologic where parasite endemic. Despite easy availability, effective anti-parasitic drugs have not been deployed effectively to control transmission. We investigated vaccine strategy prevent Such would interrupt parasite’s life cycle eliminate source for humans. Two...
Synthesis of a cytotoxic dihydrochalcone, first isolated from traditional Amazonian medicinal plant Iryanthera juruensis Warb (Myristicaceae), followed by comprehensive SAR analysis saturated and unsaturated chalcone synthetic intermediates, led to the identification analogues with selective significant in vitro anti-Trypanosoma cruzi activity. Further studies were undertaken synthesis 21 new chalcones containing two allyloxy moieties that resulted discovery 2′,4′-diallyloxy-6′-methoxy...
Chagas disease affects 8–11 million people throughout the Americas. Early detection is crucial for timely treatment and to prevent non-vectorial transmission. Recombinant antigen-based rapid tests had high sensitivity specificity in laboratory evaluations, but no Peruvian specimens were included previous studies. We evaluated Stat-Pak Trypanosoma Detect from Bolivia Peru. Specimens positive by three conventional assays confirmed positives; negative two or more negatives. In Bolivian...
To determine the frequency of spinal neurocysticercosis (NCC) in patients with basal subarachnoid NCC compared that individuals viable limited intraparenchymal (≤20 live cysts brain).We performed a prospective observational case-control study involving cisterns or only NCC. All underwent MRI examinations brain and entire cord to assess involvement.Twenty-seven NCC, 28 were included study. Spinal involvement was found 17 one patient (odds ratio 40.18, 95% confidence interval 4.74-340.31; p <...
Congenital Trypanosoma cruzi transmission is now estimated to account for 22% of new infections, representing a significant public health problem across Latin America and internationally. Treatment during infancy highly efficacious well tolerated, but current assays early detection fail detect >50% infected neonates, 9-month follow-up low. Women who presented delivery at 2 urban hospitals in Santa Cruz Department, Bolivia, were screened by rapid test. Specimens from infants women tested...
ABSTRACT Species-specific identification of human tapeworm infections is important for public health purposes, because prompt Taenia solium carriers may prevent further cysticercosis (a major cause acquired epilepsy). Two practical methods the differentiation cestode proglottids, (i) routine embedding, sectioning, and hematoxylin-eosin (HE) staining (ii) PCR with restriction enzyme analysis (PCR-REA), were tested on samples from 40 individuals infected T. ( n = 34) or saginata 6)....
The discordance between extremely high seroprevalence of Taenia solium antibodies in disease-endemic populations, relatively few symptomatic cases neurocysticercosis, and background levels putatively inactive brain lesions (mainly calcifications) seronegative controls have confused researchers, clinicians, epidemiologists the last decade. We reviewed longitudinal serologic data from general population serosurveys 3 different areas Peru Colombia found that approximately 40% seropositive...
We developed a serologic assay to identify adult Taenia solium tapeworm carriers using excretory/secretory (TSES) antigens collected from in vitro cultured T. tapeworms. To taeniasis-specific we used an immunoblot with serum samples and cysticercosis patients. Antigens were identified that reacted antibodies present taeniasis cases not those Using persons confirmed infections, the test was determined be 95% (69 of 73) sensitive. Serum (n = 193) other parasitic including saginata do contain...
<b>Objectiue</b> To compare the effectiveness of two regimens albendazole therapy for neurocysticercosis. <b>Design</b> Randomized, double-blind clinical trial. <b>Settings</b> Patients admitted to neurologic wards in Lima, Peru. <b>Patients</b> Adult patients with active neurocysticercosis demonstrated by CT and Western blot (immunoblot). <b>Intervention</b> One week (n = 25) versus 2 weeks therapy. <b>Measurements</b> Decrease number cysts on CT. <b>Results</b> Effectiveness was 78%, no...
Sera from 71 patients with surgically confirmed hydatid disease (which is caused by Echinococcus granulosus) were studied an enzyme-linked immunoelectrotransfer blot (EITB) assay. either other cestode infections or another illness used as controls. Results of the EITB test for hydatidosis compared those double-diffusion (DD5) and immunosorbent assay (ELISA). In bovine lyophilized fluid, three antigen bands 8, 16, 21 kDa diagnostically important. The sensitivity using these was 80% hepatic...
Neurocysticercosis is the main cause of acquired epilepsy in developing countries and an emerging disease United States. Introduction immunoblot assay provided a new tool for diagnosis monitoring neurocysticercosis. This study analyzed relationship between clinical characteristics cerebral infection (number type lesions) plus baseline response on changes observed after therapy. Reaction to all 7 diagnostic bands was associated with severe (more lesions). Seventeen patients (35%) had no...
"Immunodiagnosis of Human Cysticercosis (Taenia solium): a Field Comparison an Antibody-Enzyme-Linked Immunosorbent Assay (ELISA), Antigen-ELISA, and Enzyme-Linked Immunoelectrotransfer Blot (EITB) in Peru" published on May 1992 by The American Society Tropical Medicine Hygiene.
Abstract We evaluated prevalence of cystic echinococcosis (CE) in a central Peruvian Highland district by using 4 diagnostic methods: ultrasonography for 949 persons, radiography 829, and 2 serologic tests 929 (2 immunoblot formats bovine hydatid cyst fluid [IBCF] recombinant EpC1 glutathione S-transferase [rEpC1-GST] antigens). For the IBCF rEpC1-GST testing, liver pulmonary CE was 4.7% 1.1% seropositivity 8.9% 19.7%, respectively. Frequency seropositive results testing 35.7% 16.7% (all...
Background. We studied women and their infants to evaluate risk factors for congenital transmission cardiomyopathy in Trypanosoma cruzi–infected women. Methods. Women provided data blood serology quantitative polymerase chain reaction (PCR). Infants of infected had tested at 0 1 month by microscopy, PCR immunoblot, 6 9 months. underwent electrocardiography (ECG). Results. Of 1696 women, 456 (26.9%) were infected; 31 (6.8%) transmitted T. cruzi infants. who higher parasite loads than those...
Human sapovirus has been shown to be one of the most important etiologies in pediatric patients with acute diarrhea. However, very limited data are available about causative roles and epidemiology community settings. A nested matched case-control study within a birth cohort diarrhea peri-urban Peru from 2007 2010 was conducted investigate attributable fraction (AF) genetic diversity sapovirus. By quantitative reverse transcription-real-time PCR (qPCR) detected 12.4% (37/299) diarrheal 5.7%...
A combined (human and porcine) mass chemotherapy program was tested in a controlled design 12 village hamlets the Peruvian highlands. single dose of 5 mg praziquantel given to eliminate intestinal taeniasis humans, two rounds oxfendazole (30 mg/kg) were administered all pigs. The total population study villages 5,658 resident individuals, porcine at beginning 716 Human treatment coverage 75%, ranging from 69% 80%. There only few refusals owners for their animals. effect intervention measured...