A5004536792- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Immunotherapy and Immune Responses
- Diagnosis and treatment of tuberculosis
- Helicobacter pylori-related gastroenterology studies
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Lymphatic System and Diseases
- Antifungal resistance and susceptibility
- Cervical Cancer and HPV Research
- Cerebrospinal fluid and hydrocephalus
- Parasitic Infections and Diagnostics
- Advancements in Transdermal Drug Delivery
- Mercury impact and mitigation studies
- Fluoride Effects and Removal
- Bacteriophages and microbial interactions
- Antimicrobial Peptides and Activities
- Research on Leishmaniasis Studies
- Quinazolinone synthesis and applications
- Analytical Chemistry and Sensors
- Trypanosoma species research and implications
- Protein Interaction Studies and Fluorescence Analysis
- Mycotoxins in Agriculture and Food
- Heat shock proteins research
- Veterinary medicine and infectious diseases
Inovio Pharmaceuticals (United States)
2024-2025
University of Massachusetts Chan Medical School
2023-2024
University of Wisconsin–Madison
2009-2020
Kansas State University
2015
University of Louisville Hospital
2013
Universidad Peruana Cayetano Heredia
2009
University of Delaware
2008
Biotechnology Institute
2008
Miami University
2007
Royal College of Physicians
1988
There are no conventional lymphatic vessels within the CNS parenchyma, although it has been hypothesized that lymphatics near cribriform plate or dura maintain fluid homeostasis and immune surveillance during steady-state conditions. However, role of these neuroinflammation is not well understood. We report undergo lymphangiogenesis in a VEGFC - VEGFR3 dependent manner experimental autoimmune encephalomyelitis (EAE) drain both CSF cells were once parenchyma. Lymphangiogenesis also...
We conducted a study of congenital Trypanosoma cruzi infection in Santa Cruz, Bolivia. Our objective was to apply new tools identify weak points current screening algorithms, and find ways improve them.Women presenting for delivery were screened by rapid conventional serological tests. For infants infected mothers, blood specimens obtained on days 0, 7, 21, 30, 90, 180, 270 concentrated examined microscopically; tests performed the day specimens. Maternal infant specimens, including...
Mycobacterium tuberculosis, a pathogen infecting one third of the world population, faces numerous challenges within host, including high levels copper. We have previously shown that M. tuberculosis CsoR is copper inducible transcriptional regulator. Here we examined hypothesis csoR necessary for maintaining homeostasis and surviving under various stress conditions. With an unmarked knockout strain, were able to characterize role in as it faced host stress. Growth demonstrated survives...
Microbial resistance to tellurite, an oxyanion of tellurium, is widespread in the biosphere, but geochemical significance this trait poorly understood. As some tellurite markers appear mediate formation volatile tellurides, potential contribution tellurite-resistant microbial strains trace element volatilization salt marsh sediments was evaluated. were isolated aerobically on basis and subsequently examined for their capacity volatilize tellurium pure cultures. The recovered either yeasts...
Galactofuranose (Galf) is present in glycans critical for the virulence and viability of several pathogenic microbes, including Mycobacterium tuberculosis, yet monosaccharide absent from mammalian glycans. Uridine 5′-diphosphate-galactopyranose mutase (UGM) catalyzes formation UDP-Galf, which required to produce Galf-containing glycoconjugates. Inhibitors UGM have therefore been sought, both as antimicrobial leads tools delineate roles Galf cells. Obtaining cell permeable probes by either...
ABSTRACT Latent tuberculosis represents a high-risk burden for one-third of the world population. Previous analysis murine identified novel transcriptional regulator encoded by Rv0348 that could control establishment persistent tuberculosis. Disruption gene from genome virulent H37Rv strain Mycobacterium revealed global impact on profiles 163 genes, including induction mammalian cell entry ( mce1 ) operon and repression significant number genes involved in hypoxia starvation responses....
SummaryH. capsulatum strain G17 (M) polysaccharide was capable of producing active resistance against intravenously induced histoplasmosis in mice. However, mice immunized with a H. whole yeast cell antigen showed greater when the immunized, and nonimmunized control were challenged by intravenous injection known numbers viable phase organism.
Doxycycline (doxy) is used in treating intracellular and extracellular infections. Liposomal (LE) antibiotics allow low-frequency dosing extended efficacy compared with standard (STD) formulations. We developed a novel sulfuric acid–loading method for doxycycline liposomes (LE-doxy). hypothesized that single s.c. injection of LE-doxy would be detectable serum at least 2 weeks concentrations equal to or better than STD-doxy bactericidal an vitro <i>Mycobacterium smegmatis</i> infection...
REVIEW article Front. Microbiol., 18 November 2010Sec. Cellular and Infection Microbiology - closed section Volume 1 2010 | https://doi.org/10.3389/fmicb.2010.00121
Tuberculosis is a worldwide health problem, given that one-third of the world's population currently infected with Mycobacterium tuberculosis. Understanding regulation virulence on molecular level will provide better understanding how M. tuberculosis can establish chronic infection. Using in vivo microarray analysis (IVMA), we previously identified group genes are activated BALB/c mouse lungs compared to vitro cultures, including rv0990c gene. Our indicated this gene member heat shock...
Abstract Tuberculosis (TB) represents a significant challenge to public health authorities, especially with the emergence of drug-resistant (DR) and multidrug-resistant (MDR) isolates Mycobacterium tuberculosis . We sought examine genomic variations among recently isolated strains M. in two closely related countries different population demography Middle East. Clinical from both Egypt Saudi Arabia were subjected phenotypic genotypic analysis on gene genome-wide levels. Isolates MDR...
Deletion of single genes from expanded gene families in bacterial genomes often does not elicit a phenotype thus implying redundancy or functional non-essentiality paralogous genes. The molecular mechanisms that facilitate evolutionary maintenance such paralogs despite selective pressures against remain mostly unexplored. Here, we investigate the evolutionary, genetic, and interaction between Helicobacter pylori cysteine-rich hcpG hcpC context H. infection cultured mammalian cells. We find...
<title>Abstract</title> Recurrent respiratory papillomatosis (RRP) is a debilitating chronic disease of the airway caused by Human Papillomavirus (HPV). Here we describe efficacy, safety, and immunogenicity from Phase 1/2 trial INO-3107, DNA immunotherapy designed to elicit T-cell responses against HPV-6 HPV-11, in adults with RRP (NCT04398433). Thirty-two eligible patients and/or HPV-11 RRP, who required ≥2 surgical interventions year preceding dosing, were administered 4 doses INO-3107...
Abstract Introduction: Recurrent respiratory papillomatosis (RRP) is a debilitating chronic disease of the airway caused by Human Papillomavirus (HPV) characterized recurrent benign tumor growth with potential for malignant transformation. The current standard care requires frequent surgeries, sequalae which have long-standing negative impacts on and vocal function. Treatments that avoid surgery targeted against HPV6 and/or HPV11 (known etiological agents RRP) are thus an area need. Here we...
An amendment to this paper has been published and can be accessed via a link at the top of paper.
Aim: Co-occurring opioid use and mental health disorders (COD) are common among people with criminal legal involvement. Reentry is a vulnerable period low treatment engagement, often resulting in relapse, reincarceration, overdose. While both linkage multicomponent COD wraparound interventions have supported reentry, little known about which most effective for engagement post release.
 Methods: This quasi-experimental study included 293 nonrandomized persons involved the system enrolled...
Abstract In a collaborative study, 7 laboratories successfully analyzed 8 different samples, in duplicate, by manual potentiometric titration method. These same samples were used concurrent study of the automated The are dissolved water and acidified, soluble chloride is determined with silver nitrate to end point. methods applicable all water-soluble certifiable colors except D&C Red No. 19, at levels &gt;0.03% sodium chloride, although there positive error very low for titration....