A5103133852- Antibiotics Pharmacokinetics and Efficacy
- Cervical Cancer and HPV Research
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Pharmaceutical studies and practices
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Synthesis and Biological Evaluation
- Immune cells in cancer
- Polyomavirus and related diseases
- RNA modifications and cancer
- Coccidia and coccidiosis research
- Glioma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmacological Effects and Toxicity Studies
- Cancer Cells and Metastasis
- interferon and immune responses
- Cancer-related Molecular Pathways
- Chronic Lymphocytic Leukemia Research
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Microtubule and mitosis dynamics
Inovio Pharmaceuticals (United States)
2020-2025
Uniformed Services University of the Health Sciences
2020
Oregon Health & Science University
2020
Wayne State University
2020
Clarke University
2020
TetraLogic Pharmaceuticals (United States)
2015-2016
University of Pennsylvania
2011
Children's Hospital of Philadelphia
2006-2010
AstraZeneca (United States)
2010
Wilmington University
2010
To evaluate the safety, immunogenicity, and efficacy of INO-3107, a DNA immunotherapy designed to elicit targeted T-cell responses against human papillomavirus (HPV) types 6 11, in adult patients with recurrent respiratory papillomatosis (RRP; NCT04398433).Eligible required ≥2 surgical interventions for RRP year preceding dosing. INO-3107 was administered by intramuscular (IM) injection followed electroporation (EP) on weeks 0, 3, 6, 9. Patients underwent debulking within 14 days prior first...
Abstract Background More effective incentives are needed to motivate paediatric oncology drug development, uncoupling it from dependency on adult development. Although the current European and North‐American legislations aim promote development for paediatrics rare diseases, children adolescents with cancer have not benefited as expected these initiatives remains first cause of death by disease in older than one. Drug childhood dependent indications their potential market. The balance...
The management of men with prostate cancer (PCa) biochemical recurrence following local definitive therapy remains controversial. Early use androgen deprivation (ADT) leads to significant side effects. Developing an alternative, clinically effective, and well-tolerated unmet clinical need. INO-5150 is a synthetic DNA that includes plasmids encoding for prostate-specific antigen (PSA) membrane (PSMA), INO-9012 plasmid interleukin-12 (IL-12). This phase 1/2, open-label, multi-center study...
Abstract We describe a selective and highly sensitive assay for actinomycin‐D (Act‐D) vincristine (VCR) in plasma employing high‐performance liquid chromatography‐tandem mass spectrometry (HPLC‐MS/MS) detection. The intraday precision (as defined by the coefficient of variation, CV) based on standard deviation replicates quality control samples ranged from 4.9 to 7.5% 6.5 11.3% with accuracy ranging 90.7 98.1% 91.2 103% Act‐D VCR, respectively. interday 7.2 10.0% 11.3 13.0% 94.3 102% 91.6%...
BY GRADE SCHOOL, most of us have a basic understanding DNA, or deoxyribonucleic acid, the essential building block human life.It's what makes our eyes blue hair straight.DNA medicines, however, are less well known and historically been unsuccessful in delivering 25 years ago was touted as revolution therapeutics. 1Contrary to popular opinion, DNA medicines not synonymous with "gene therapy," but they challenged by same biases presumptions, because that, failed gain therapeutic ground...
To develop a method for drug dosing and pharmacokinetic (PK) sampling in children with cancer from single indwelling central venous catheter that minimized contamination.A benchtop system was designed to simulate clearing actinomycin-D (AMD) vincristine (VCR) catheters. The authors evaluated the effects of flush volume, composition pH, timed instillation, number blood-draw return cycles on residual concentrations. A proof-of-principle study conducted three pediatric patients paired PK...
7060 Background: Inhibitor of Apoptosis Proteins (IAPs) are a family molecules that dysregulated in myeloid stem cell disorders and prevent programmed death. SMAC (second mitochondrial activator caspase) is an endogenous antagonist IAPs counteracts their anti-apoptotic effect. Birinapant potent mimetic phase Ib study patients with MDS it demonstrated acceptable safety profile early signs clinical activity. Methods: This was multicenter, randomized, double-blind, placebo-controlled 5-AZA or...
<div>Abstract<p><b>Purpose:</b> <i>KRAS</i> is the most commonly mutated oncogene in human tumors. <i>KRAS</i>-mutant cells may exhibit resistance to allosteric MEK1/2 inhibitor selumetinib (AZD6244; ARRY-142886) and AKT inhibitors (such as MK-2206), combination of which overcome both monotherapies.</p><p><b>Experimental Design:</b> We conducted a dose/schedule-finding study evaluating MK-2206 patients with advanced...
BY GRADE SCHOOL, most of us have a basic understanding DNA, or deoxyribonucleic acid, the essential building block human life.It's what makes our eyes blue hair straight.DNA medicines, however, are less well known and historically been unsuccessful in delivering 25 years ago was touted as revolution therapeutics. 1Contrary to popular opinion, DNA medicines not synonymous with "gene therapy," but they challenged by same biases presumptions, because that, failed gain therapeutic ground...
Abstract Introduction: Human papilloma virus (HPV)-6 and 11-associated aerodigestive neoplasms can occur in the oropharynx, larynx, upper respiratory tract. HPV is implicated recurrent papillomatosis (RRP), most common benign tumor of laryngeal epithelium. RRP rare, with an incidence rate 1.8 per 100,000 adults United States, but clinical course be significant patients have a higher risk developing cancer. DNA therapies focusing on treating HPV-related disease may benefit RRP. Methods: A...
Understanding the processes of immune system and interactions at a cellular level is essential to identify validate new targets, determine therapy approaches. Advanced cell analysis tools can be used unlock secrets interactions, potentially enable future breakthroughs in immune-based therapies. Integrated software key component advanced platforms, allowing for interactive assay development evaluation large datasets through multiparameter data visualization. From linking well together...