A5055003537- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Pharmaceutical studies and practices
- Cancer therapeutics and mechanisms
- CAR-T cell therapy research
- Lung Cancer Research Studies
- Alzheimer's disease research and treatments
- Pain Mechanisms and Treatments
- Peroxisome Proliferator-Activated Receptors
- Acute Lymphoblastic Leukemia research
- Pain Management and Placebo Effect
- Cardiac electrophysiology and arrhythmias
- Folate and B Vitamins Research
- Ion Channels and Receptors
- Atrial Fibrillation Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- Plant-based Medicinal Research
- Venomous Animal Envenomation and Studies
- Diabetic Foot Ulcer Assessment and Management
- Metabolism and Genetic Disorders
- Ethics and Legal Issues in Pediatric Healthcare
- Asthma and respiratory diseases
- Dementia and Cognitive Impairment Research
- Ethics in Clinical Research
London Cancer
2021-2025
GlaxoSmithKline (United Kingdom)
2002-2021
Age UK
2021
National Cancer Research Institute
2020
Current treatments of neuropathic pain arising from conditions such as nerve injury/compression are only partially effective, and limited in their use by side-effects. p38 mitogen-activated protein kinase (MAPK) is involved the regulation synthesis inflammatory mediators, target for a novel class cytokine-suppressive anti-inflammatory drugs. inhibitors may reduce neuronal sensitisation preclinical models pain, particularly where there substantial component. An exploratory, multicentre,...
Here we report the first multi-center clinical trial in Alzheimer's disease (AD) using fluorodeoxyglucose positron emission tomography ([18 F]FDG-PET) measures of brain glucose metabolism as primary outcome. We contrasted effects 12 months tre
The SARS-Cov-2 (COVID-19) pandemic remains a major worldwide public health issue. Initially, improved supportive and anti-inflammatory intervention, often employing known drugs or technologies, provided measurable improvement in management. We have recently seen advances specific therapeutic interventions vaccines. Nevertheless, it will be months before most of the world’s population can vaccinated to achieve herd immunity. In interim, hyperbaric oxygen (HBO2) treatment offers several...
Airway sensory nerves involved in the cough reflex are activated by adenosine triphosphate (ATP) agonism of P2X purinoceptor 3 (P2X3) receptors. Transient receptor potential vanilloid 4 (TRPV4) channel activation causes ATP release from airway cells, and it is hypothesised that a TRPV4-ATP-P2X3 axis contributes to chronic cough. An adaptive study was run determine if TRPV4 inhibition, using selective blocker GSK2798745, effective reducing cough.A two-period randomised, double blinded,...
Abstract Background More effective incentives are needed to motivate paediatric oncology drug development, uncoupling it from dependency on adult development. Although the current European and North‐American legislations aim promote development for paediatrics rare diseases, children adolescents with cancer have not benefited as expected these initiatives remains first cause of death by disease in older than one. Drug childhood dependent indications their potential market. The balance...
High-dose chemotherapy with autologous stem cell transplant (ASCT) has been a mainstay of high-risk neuroblastoma treatment for several decades, demonstrating improvements in event-free survival but risks serious or even life-threatening acute toxicities, severe long-term adverse health effects survivors, and ongoing contention regarding overall benefit. The merits ASCT the modern era immunotherapy are source debate among parents, advocates, some physicians. Here we examine evidence against...
Importance In poor-prognosis children’s cancers, new therapies may carry fresh hope for patients and parents. However, there is an absolute requirement any therapy to be properly evaluated fulfill scientific, regulatory, reimbursement requirements. Randomized clinical trials (RCTs) are considered the gold standard, but no consensus exists on how when they should deployed best meet needs of all stakeholders. Objective To conduct a multistakeholder meeting foster greater shared understanding...
Alzheimer's Disease (AD) leads to a progressive reduction of brain metabolism, which correlates with disease severity and is detectable 18F-FDG PET, Rosiglitazone was demonstrated have favorable effect on cognitive function in AD1, 2. We assessed the effects rosiglitazone metabolism over 12-month period pilot double-blind, placebo controlled, randomized parallel group study. Eighty patients mild-to-moderate AD (MMSE 16-23) were 1:1 ratio receive daily dose either (8 mg extended release), or...
Abstract A diverse range of non‐cardiovascular drugs are associated with QT interval prolongation, which may be a potentially fatal ventricular arrhythmia known as torsade de pointes. has been assessed for two recent submissions at GlaxoSmithKline. Meta‐analyses ECG data from several clinical pharmacology studies were conducted the submissions. general fixed effects meta‐analysis approach using summaries individual was used to calculate pooled estimate and 90% confidence difference between...
Alzheimer's Disease (AD) leads to a progressive reduction of brain metabolism, which correlates with disease severity and is detectable 18F-FDG PET, Rosiglitazone was demonstrated have favorable effect on cognitive function in AD 1., 2.. We assessed the effects rosiglitazone metabolism over 12-month period pilot double-blind, placebo controlled, randomized parallel group study. Eighty patients mild-to-moderate (MMSE 16-23) were 1:1 ratio receive daily dose either (8 mg extended release), or...