A5023488652- Voice and Speech Disorders
- Tracheal and airway disorders
- Dysphagia Assessment and Management
- Head and Neck Cancer Studies
- Cervical Cancer and HPV Research
- Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Respiratory and Cough-Related Research
- Airway Management and Intubation Techniques
- Immunotherapy and Immune Responses
- Cancer and Skin Lesions
- Esophageal and GI Pathology
- Head and Neck Surgical Oncology
- Phonetics and Phonology Research
- Cancer Immunotherapy and Biomarkers
- Cleft Lip and Palate Research
- Sinusitis and nasal conditions
- Ear and Head Tumors
- Transplantation: Methods and Outcomes
- Infectious Diseases and Mycology
- Nasal Surgery and Airway Studies
- RNA Interference and Gene Delivery
- Music and Audio Processing
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Stuttering Research and Treatment
University of Cincinnati
2021-2025
University of Cincinnati Medical Center
2021-2025
Cincinnati Children's Hospital Medical Center
2022
NorthShore University HealthSystem
2015-2021
Harvard University
2009-2014
Massachusetts General Hospital
2009-2014
Harvard University Press
2012
Cleveland Clinic
2005-2010
Roosevelt Hospital
2010
St. Luke's-Roosevelt Hospital Center
2010
Abstract Objectives: To evaluate whether the timing of early (≤6 months from time nerve injury) vs. late (>6 months) injection medialization laryngoplasty impacts need for subsequent open‐neck reconstruction to restore vocal function in patients with unilateral cord paralysis. Study Design: Retrospective chart review. Methods: A total 112 outpatient or hospitalized adults dysphonia resulting postsurgical idiopathic paralysis were identified who injected as initial treatment within 1 year...
Objectives: Photoangiolytic laser treatment of recurrent respiratory papillomatosis (RRP) is effective, but does not reliably prevent recurrence. Therefore, sublesional injections the antiangiogenic agent bevacizumab (Avastin) were given to assess adjunctive effect on disease Since a new therapeutic modality for RRP, there also primary safety objectives determine whether was negative impact voice and local or systemic complications. Methods: A prospective open-label investigation conducted...
OBJECTIVE: To evaluate the diagnosis and management of isolated sphenoid sinus disease by using current rhinologic standard care. STUDY DESIGN: Retrospective chart review. RESULTS: Fifty sequential, symptomatic patients were studied. Presenting symptoms included headache or facial pain (88%), rhinorrhea (46%), nasal congestion (26%). All underwent CT imaging, demonstrating bony changes dehiscences (42%), a mass (24%), complete opacification (22%). Eighty percent required surgical...
To evaluate the safety, immunogenicity, and efficacy of INO-3107, a DNA immunotherapy designed to elicit targeted T-cell responses against human papillomavirus (HPV) types 6 11, in adult patients with recurrent respiratory papillomatosis (RRP; NCT04398433).Eligible required ≥2 surgical interventions for RRP year preceding dosing. INO-3107 was administered by intramuscular (IM) injection followed electroporation (EP) on weeks 0, 3, 6, 9. Patients underwent debulking within 14 days prior first...
Increasing evidence supports the use of laryngeal injections antiangiogenic agent bevacizumab (Avastin) for adjuvant treatment recurrent respiratory papillomatosis (RRP). A recent prospective open-label investigation, approved by US Food and Drug Administration, employing 12.5 mg sublesional demonstrated single-site efficacy without complications; however, safety multiple-site higher dosing has not yet been reported. The primary objective this study was to report on increased doses RRP.Two...
Objectives/Hypothesis The purpose of this study is to develop consensus on key points that would support the use systemic bevacizumab for treatment recurrent respiratory papillomatosis (RRP), and provide preliminary guidance surrounding modality. Study Design Delphi method‐based survey series. Methods A multidisciplinary, multi‐institutional panel physicians with experience using RRP was established. method used identify obtain characteristics associated across five domains: 1) patient...
The morbidity of glottic insufficiency resulting from unilateral vocal fold immobility may significantly compromise postoperative recovery in patients with decreased pulmonary reserve or inability to protect their airway. Injection medialization laryngoplasty is an effective means treating due immobility. purpose this study present our experience bedside transoral injection the immediate period.Case series chart review.Academic tertiary care hospital.Patient demographics, clinical...
Abstract Background: The differential diagnosis of endolaryngeal mesenchymal neoplasms includes a wide spectrum benign and malignant pathologies, which have been rarely photo-documented assessed as group. Methods: Non-epithelial the endolarynx seen at our centre from 2002 to 2011 ( n = 38; 36 treated institution) were retrospectively reviewed, with attention clinical presentation, radiographic imaging, operative management, histology, pre- post-operative endoscopy. Submucosal squamous cell...
Objectives: Surgery and radiotherapy routinely provide high cure rates in treating early glottic cancer. Therefore, key metrics for success are optimal voice outcome preservation of future cancer treatment options. Remarkably, there is a paucity pretreatment versus posttreatment data. Angiolytic KTP (potassium titanyl phosphate) laser with ultranarrow margins was initiated to better preserve vocal function. Given that effective oncological results have been achieved, it hypothesized this...
Abstract Objectives: Recently, the 532 nm pulsed potassium-titanyl-phosphate laser has emerged as an effective angiolytic for treating mucosal lesions of larynx in operating theatre and clinic. We sought to assess current impact on our laryngeal surgery practice. Study design: Retrospective review 710 patients undergoing endoscopic over a one-year period. Methods: Medical records procedures were reviewed; 386/710 had been performed clinic 324/710 under general anaesthesia. Indications...
Comparing Derkay anatomical score at time of procedure, disease characteristics, and mean treatment interval among adult pediatric patients with recurrent respiratory papillomatosis (RRP).Restrospective study.Retrospective review juvenile-onset (JO) adult-onset (AO) RRP treated longitudinally institutions from 1999 to 2019. Patients were included if they had a tissue diagnosis papilloma least 12-month follow-up.One hundred twelve met inclusion criteria (68 JO-RRP 44 AO-RRP). All stratified...
Objectives: There is increased interest in using cepstral-based acoustic measures for objective clinical voice assessment because of their apparent advantages over more time-honored methods, but there a paucity information about how these newer relate to underlying phonatory mechanisms. Methods: We investigated the relationships between cepstral peak magnitude (CPM) and high-speed videoendoscopy (HSV)–based vocal fold function 20 subjects who underwent phonomicrosurgery lesions. Acoustic...
Management of early glottic cancer subsequent to failed radiotherapy is challenging, especially in balancing oncological control and function preservation. Patients frequently have been incentivized against surgical management thus undergone as initial treatment. This history compounds the difficulty discussions about after recurrence. Typically, endoscopic salvage has less morbidity than transcervical partial laryngectomy clearly desirable over total laryngectomy. However, there are...
Objectives: Preservation of the maximum amount subepithelial superficial lamina propria (SLP) remains an important goal during microlaryngoscopic surgery phonatory mucosa. Volume expansion SLP (Reinke's space) with infusion saline solution has been widely adopted since its introduction in 1991. This technique evolved so that it is currently used to assist determining depth vocal fold disease, defining residual pliable SLP, enhancing microsurgical precision, and identifying unrecognized...
Objective To compare improvement in patient‐reported outcomes (PROM) persons undergoing endoscopic and open surgical management of Zenker diverticula (ZD). Methodology Prospective, multicenter cohort study all individuals enrolled the Prospective OUtcomes Cricopharyngeus Hypertonicity (POUCH) Collaborative who underwent surgery for ZD. Patient survey, radiography reports, 10‐item Eating Assessment Tool (EAT‐10) pre‐ post‐procedure were abstracted from a REDCap database, which summarized...
Objectives The aim of the study was to identify trends in postoperative management persons undergoing surgery for Zenker diverticula (ZD) by evaluating length stay (LOS), diet on discharge, and imaging with or without surgical complication. Methods Prospectively enrolled adult patients cricopharyngeal muscle dysfunction from August 1, 2017 February 2023 were included. Data extracted a multi‐institutional REDCap database, summarizing means, medians, percentages, frequencies. Fisher's exact...
Selective reinnervation for bilateral vocal fold paralysis has been successful in animal models and shows promise humans, but detailed, surgically relevant measurements performing this the human larynx are not readily available.Anatomical study describing anatomy gender differences of recurrent laryngeal nerve, with specific attention to distance between posterior cricoarytenoid (PCA) branch interarytenoid (IA) branch.Dissection 20 cadaveric larynges.The mean PCA IA branches on left side...
Objectives: We assessed the likelihood of arytenoid dislocation during intubation through application controlled force. Methods: Six cadaveric human larynges were mounted in an apparatus for simulating forcible collision with complexes. An endotracheal tube tip probe (ETTP) was used to push one complex, and a non-slip (NSP) tested on other. Increasing pressure applied until probes either slipped or reached 5 kg Dissection then performed assess integrity cricoarytenoid ligament. The forces...
2502 Background: Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV) types 6 & 11. RRP proliferates in the tract impacting breathing, swallowing, and voice carries a 1-4% risk of malignant transformation. There no curative therapy for RRP. Given tolerized host immune response against HPV, part through upregulation PD1:PDL1 axis, safety efficacy pembrolizumab (pembro) as novel treatment this benign tumor patient (pt) population was evaluated phase II...