A5084503522- Tracheal and airway disorders
- Voice and Speech Disorders
- Dysphagia Assessment and Management
- Airway Management and Intubation Techniques
- Ear and Head Tumors
- Tumors and Oncological Cases
- Reconstructive Surgery and Microvascular Techniques
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Salivary Gland Tumors Diagnosis and Treatment
- Vascular Malformations and Hemangiomas
- Reconstructive Facial Surgery Techniques
- Vitamin K Research Studies
- Lung Cancer Treatments and Mutations
- Surgical Simulation and Training
- Cancer-related gene regulation
- Facial Nerve Paralysis Treatment and Research
- Head and Neck Cancer Studies
- Peptidase Inhibition and Analysis
- Thyroid and Parathyroid Surgery
- Hemophilia Treatment and Research
- Virus-based gene therapy research
- Fibroblast Growth Factor Research
- Preterm Birth and Chorioamnionitis
- Pregnancy-related medical research
- Blood Coagulation and Thrombosis Mechanisms
Georgetown University
2014-2025
MedStar Georgetown University Hospital
2014-2025
Georgetown University Medical Center
2010-2023
State of Illinois
2020
Royal Derby Hospital
2016
St. Luke's-Roosevelt Hospital Center
2008
Cornell University
2008
Washington Hospital
2007
University College London
1985
National Hospital for Neurology and Neurosurgery
1985
A patient with a 20-year history of recurrent respiratory papillomatosis had progressive, bilateral tumor invasion the lung parenchyma. We used conditional reprogramming to generate cell cultures from patient's normal and tumorous tissue. Analysis revealed that laryngeal cells contained wild-type 7.9-kb human papillomavirus virus type 11 (HPV-11) genome, whereas pulmonary 10.4-kb genome. The increased size latter viral genome was due duplication promoter oncogene regions. Chemosensitivity...
To understand the presentation and clinical course of angiotensin-converting enzyme (ACE) inhibitor-induced angioedema to determine management factors associated with progression airway compromise.Retrospective chart review patients taking ACE inhibitors who presented emergency department between December 1999 July 2004 (n = 228). Clinical presentation, treatment, were analyzed.The oral cavity was most common location upper-airway angioedema. Twenty-two (10%) required intubation, all...
Objectives/Hypothesis The purpose of this study is to develop consensus on key points that would support the use systemic bevacizumab for treatment recurrent respiratory papillomatosis (RRP), and provide preliminary guidance surrounding modality. Study Design Delphi method‐based survey series. Methods A multidisciplinary, multi‐institutional panel physicians with experience using RRP was established. method used identify obtain characteristics associated across five domains: 1) patient...
This study aims to evaluate the feasibility and utility of a novel, open-source 3D printed simulator for practicing laryngeal surgery skills in clinic setting. Device development validation. A tertiary medical center. was created using computer-aided design software printed. Ten otolaryngology residents completed exercises utilizing flexible video laryngoscope visualization. The training involved 3 microsurgery tasks: (1) suture removal from simulated vocal cords, (2) silicone cord polyps,...
Abstract Objectives/Hypothesis: To characterize the anatomic distribution of segmental hemangiomas larynx and to describe indications for treatment modalities. Study Design: Retrospective chart review. Methods: We performed a retrospective review patients with cutaneous at tertiary care center over 4‐year period. Only upper airway were studied. reviewed within course each patient. Results: Of 1,226 hemangiomas, 108 (9%) in distribution. There 56 (52%) who had V3 pattern, 16 (29%)...
Objective Phonosurgery requires technical precision and careful tissue handling. Typically, phonosurgical procedures require single‐operator techniques, making it difficult for novice residents to develop necessary skills. We developed a low‐cost phonosurgery simulator allow practice acquisition of microlaryngeal Study Design Validation study assessing the simulator's face content validity in surgical education. Methods For construction, is composed simulation station laryngeal modules, each...
Recurrent respiratory papillomatosis (RRP) is a benign neoplasm of the larynx caused mainly by human papillomavirus type 6 or 11 and its standard treatment involves repeated surgical debulking laryngeal tumors. However, significant morbidity occasional mortality due to multiple recurrences occur. Conditional reprogramming (CR) was used establish HPV-6 positive culture from an RRP patient, named GUMC-403. High-throughput screening performed at National Center for Advanced Technology (NCATS)...
Pharyngoesophageal diverticulum is a rare complication following anterior cervical discectomy and fusion (ACDF). Dysphagia well-documented associated with ACDF. It may result postoperatively from variety of etiologies, including hardware displacement, pharyngeal edema, or vocal fold paresis. One cause persistent dysphagia the formation hypopharyngeal diverticulum, reported in literature 9 previous cases. Such diverticula after ACDF surgery have pathogenesis that distinct typical Zenker...
Abstract Tracheostomy scar management is aimed at filling lost deep tissue bulk, the correction of tracheal skin tug, and a tension‐free closure that falls more naturally into neck folds. Three cases are used to illustrate major principles involved in tracheostomy scars. Those reconstructive 1) re‐approximation individual layers for improved contour release 2) deficit, using de‐epithelialization, muscle flaps, or acellular dermal grafts, 3) excision hypertrophic scarring keloids, 4)...
Objective Vocal fold injection medialization (VFIM) is widely used as an initial treatment for unilateral vocal paralysis (UVFP). Current practices employ materials that share the limitation of temporary clinical effect from variable resorption rates. A novel silk protein microparticle‐hyaluronic acid‐based material (silk‐HA) has demonstrated cellular infiltration and tissue deposition may portend a durable effect. We report on ≥12 months outcomes after VFIM with silk‐HA. Methods Prospective...
Davison, Steven P. D.D.S., M.D.; Grant, Nazaneen N. Schwarz, Karl A. M.Sc., Iorio, Matthew L. B.A. Author Information
Abstract Background Juvenile-onset recurrent respiratory papillomatosis (JO-RRP) is a human papilloma virus-mediated progressive benign neoplasm that affects children and young adults. Primary management consists of regular surgical debulking to maintain airway patency vocal function. Like condyloma acuminata, JO-RRP associated with immune dysregulation, T cells isolated from papillomas express an anergic phenotype. Therefore, we hypothesized programmed death protein 1 axis inhibition could...
Laryngoscope, 124:2136–2138, 2014
A 46-YEAR-OLD MAN PRESENTED WITH several-month history of dysphagia. He was otherwise healthy, denied tobacco or alcohol use, and reported a tonsillectomy. His voice clear. Flexible laryngoscopy demonstrated polypoid mass that filled the right piriform sinus spilled into laryngeal introitus (Figure 1). The vocal folds were mobile. contrast computed tomogram neck showed cystic-solid lesion in region sinus, with an associated effect. patient elected to undergo transoral laser excision...
The potential for the misinterpretation of positron-emission tomography (PET) scans in context a possible malignancy has been confirmed case report showing increased 18F-fluorodeoxyglucose (FDG) uptake after unilateral vocal fold augmentation medialization. We sought to expand these findings by investigating FDG larger cohort patients via retrospective chart review. examined records 15 adults-8 men and 7 women-who had undergone paralysis at least one subsequent PET scan. differences standard...
Objective 1) Review anatomy of the nasolacrimal apparatus. 2) Learn about common primary tumors apparatus and their clinical presentation. 3) Present a rare type duct tumor. 4) Discuss utility combined endoscopic external techniques for removal tumors. Method Retrospective case report review literature. Results A 67‐year‐old woman presented with cough post‐nasal drip. Examination revealed right‐sided nasal cavity mass anterior to middle turbinate. Upon further questioning, she reported...
To evaluate the effectiveness of serial transvaginal cervical lengths (CL) scans with or without interventions including cerclage (CC) and/or progesterone therapy in preventing preterm birth (PTB). This is a prospective cross-sectional study. Women presenting to PTB prevention clinic from January 2014 were included. Exposure and outcome data obtained electronic maternity records. 168 women considered be at risk their previous history included They scanned serially 14 24 weeks gestation...