A5043990824- Dysphagia Assessment and Management
- Voice and Speech Disorders
- Tracheal and airway disorders
- Head and Neck Cancer Studies
- Esophageal and GI Pathology
- Oral health in cancer treatment
- Airway Management and Intubation Techniques
- Cleft Lip and Palate Research
- Cervical Cancer and HPV Research
- Trauma Management and Diagnosis
- Infectious Diseases and Mycology
- Gastroesophageal reflux and treatments
- Otolaryngology and Infectious Diseases
- Congenital Diaphragmatic Hernia Studies
- Head and Neck Surgical Oncology
- Oropharyngeal Anatomy and Pathologies
- Salivary Gland Tumors Diagnosis and Treatment
- Foreign Body Medical Cases
- Head and Neck Anomalies
- Gastrointestinal disorders and treatments
- Innovations in Medical Education
- Neuroendocrine Tumor Research Advances
- Stuttering Research and Treatment
- Orthopedic Infections and Treatments
- Ear and Head Tumors
Amsterdam University Medical Centers
2020-2025
University of Amsterdam
2023-2024
Vrije Universiteit Amsterdam
2005-2022
National Medical Research Center of Dentistry and Maxillofacial Surgery
2022
The Netherlands Cancer Institute
2020
Amsterdam UMC Location Vrije Universiteit Amsterdam
2008-2017
Maastricht University Medical Centre
2001-2004
Cologne Business School
2002
Maastricht University
2002
Complex interactions between DNA herpesviruses and host factors determine the establishment of a life-long asymptomatic latent infection. The lymphotropic Epstein-Barr virus (EBV) seems to avoid recognition by innate sensors despite massive transcription immunostimulatory small RNAs (EBV-EBERs). Here we demonstrate that in latently infected B cells, EBER1 transcripts interact with lupus antigen (La) ribonucleoprotein, avoiding cytoplasmic RNA sensors. However, coculture experiments observed...
A Speech Handicap Index (SHI) questionnaire with 30 items on speech problems was developed and validated in 92 patients cancer of the oral cavity or pharynx 110 healthy subjects.All subjects completed SHI European Organization for Research Treatment Cancer (EORTC) Quality Life Questionnaire-Head & Neck module (QLQ-H&N35). Twenty-nine twice to assess test-retest reliability.Factor analysis identified 2 well-defined subscales, assessing function psychosocial functioning related speech....
Abstract Background. The aim of this study was to analyze swallowing outcome in advanced oral/oropharyngeal cancer patients treated with microvascular reconstructive surgery and adjuvant radiotherapy. Methods. Eighty were included. Patient, tumor, treatment factors assessed. Postoperative videofluoroscopic studies (VFSS) scintigraphy tests performed at 6 ( n = 54 vs 44) 12 32 37) months. Swallowing parameters such as the oropharyngeal swallow efficiency Penetration/Aspiration Scale analyzed....
The objective of this study is to assess swallowing and speech outcome after chemoradiation therapy for head neck cancer, based on the patient-reported measures Swallowing Quality Life Questionnaire (SWAL-QOL) Speech Handicap Index (SHI), both provided with cut-off scores. This a cross-sectional study. Department Otolaryngology/Head Neck Surgery University Medical Center. Sixty patients, 6 months 5 years squamous cell carcinoma. SHI, validated in Dutch Associations were tested between...
After treatment for early glottic carcinoma, a considerable number of patients end up with voice problems that interfere daily life activities. The objective this randomized and controlled study was to assess the efficacy therapy in these patients.Of 177 patients, 6-120 months after 70 (40%) suffered from impairment based on 5-item screening questionnaire. Approximately 60% those were not interested participating current study. Twenty-three who willing participate assigned randomly either...
During a 6-week course of (chemo)radiation many head and neck cancer patients have to endure radiotherapy-induced toxicity, negatively affecting patients' quality life. Pretreatment counseling combined with self-help exercises could be provided inform possibly prevent them from having speech, swallowing, shoulder problems during after treatment.Our goal was investigate the feasibility multimodal guided exercise program entitled Head Matters in patients.Head treated primary or surgery were...
Objectives/Hypothesis The purpose of this study is to develop consensus on key points that would support the use systemic bevacizumab for treatment recurrent respiratory papillomatosis (RRP), and provide preliminary guidance surrounding modality. Study Design Delphi method‐based survey series. Methods A multidisciplinary, multi‐institutional panel physicians with experience using RRP was established. method used identify obtain characteristics associated across five domains: 1) patient...
Radiation-induced aspiration is a serious complication following (chemo)radiation for head and neck cancer. The standard set of swallowing organs at risk (SWOARs) does not include all aspiration-related (OARs). An alternative proposed in earlier work includes definition delineation atlas additional OARs, called Functional Swallowing Units (FSU). purpose this study was to compare two NTCP models late aspiration, based on either SWOARs only or the FSU concept. Data from 189 patients were...
A newly proposed classification by the European Laryngological Society (ELS) of glottic lesions narrow-band imaging (NBI) divides their vascular patterns into longitudinal and perpendicular ones. The latter are further subdivided wide narrow patterns. longitudinal, wide, characteristic benign disease, papilloma, malignancy, respectively. aim study was to investigate diagnostic effectiveness classification. Forty patients with underwent microlaryngoscopy. all vocal cords were defined NBI....
Progress testing in the Netherlands was originally developed at Maastricht University. Since late 1990s, a collaboration has started between three medical schools to jointly produce and administer progress test. Currently, test is administered five out of eight Netherlands. The led substantial decrease necessary resources per participating school. Also, data provide rich source for comparisons can be instrumental inducing improvements curricula. Logistics large-scale administrations possible...
The purpose of this study is to evaluate computerized monitoring speech and swallowing outcomes its impact on quality life (QoL) emotional well-being in head neck cancer patients an outpatient clinic.Sixty-seven patients, treated by single or multimodality treatment, completed the EORTC QLQ-C30 QLQ-H&N35 questionnaires Hospital Anxiety Depression Scale clinic, using a touch screen computer system (OncoQuest), at baseline (at time diagnosis) first follow-up (1 month after end treatment).Tumor...
<b><i>Aim:</i></b> To develop a Web-based self-care program for patients after total laryngectomy according to participatory design approach. <b><i>Methods:</i></b> We conducted needs assessment with laryngectomees (n = 9) and their partners 3) by means of focus group interview. In 4 sessions, requirement plan was formulated team health care professionals 10) translated into prototype. An e-health application built including illustrated...
Background Sinonasal symptoms are a common feature of primary ciliary dyskinesia (PCD); however, literature about their severity and frequency, particularly during the life course, is scarce. Using baseline data from Ear, nose throat (ENT) Prospective International Cohort PCD patients, we describe sinonasal disease in PCD. Methods We included participants who had routine examination which they completed questionnaire. compared frequency reported findings among children adults, identified...
In total laryngectomy, the neopharynx can be closed in several ways. It is suggested that a pseudo-diverticulum seen more frequently patients with vertical closure than "T"-shaped closure, causing postoperative dysphagia. We report results of treated and regard to formation dysphagia.In our retrospective cohort study, we identified 117 consecutive laryngectomized VU University Medical Center Amsterdam between March 2009 December 2013. Evaluations statistical analysis outcome measures (the...
This study explores the quality of life among patients with recurrent respiratory papillomatosis (RRP) after vocal fold surgery as measured by outcome scores Voice Handicap Index (VHI) and Distress Thermometer Problem List in Patients Recurrent Respiratory Papillomatosis (DT&PL). Differences were explored within independent variables age, surgical frequency, weeks since last operation, gender, HPV type, location, vaccination Gardasil©, a patient's request to speak speech-language pathologist.
To assess the impact of patient reported voice outcome on quality life and emotional functioning in patients treated for recurrent respiratory papillomatosis (RRP).Cross-sectional.All adult RRP between 1984 2008 were asked to participate. Outcome measures obtained from questionnaires including VHI (Voice Handicap Index), HADS (Hospital Anxiety Depression Scale), 36-Item Short Form Health Survey (SF-36), Utrechtse Coping List.Out 45 included patients, 34 (22 males,12 females) participated...
Colorectal carcinomas are among the most common tumor types and generally treated with palliative chemotherapy in case of metastatic disease. Here, we describe a 46-year-old patient rectal carcinoma who received second-line therapy irinotecan developed isolated transient dysarthria (with normal MR imaging brain) following each administration irinotecan. Neurological logopedical evaluation revealed that predominantly resulted from reduced capacity fine-tuning motor functions tip tongue...
Background and purposeRadiation-induced aspiration is a serious complication following (chemo)radiation for head neck cancer. The standard set of swallowing organs at risk (SWOARs) does not include all aspiration-related (OARs). An alternative proposed in earlier work includes definition delineation atlas additional OARs, called Functional Swallowing Units (FSU). purpose this study was to compare two NTCP models late aspiration, based on either SWOARs only or the FSU concept.Methods...