A5015419532- Vascular Malformations and Hemangiomas
- Tumors and Oncological Cases
- Tracheal and airway disorders
- Cleft Lip and Palate Research
- Teratomas and Epidermoid Cysts
- Craniofacial Disorders and Treatments
- Ear and Head Tumors
- Vascular Malformations Diagnosis and Treatment
- Head and Neck Anomalies
- Vascular Anomalies and Treatments
- Vascular Tumors and Angiosarcomas
- Voice and Speech Disorders
- Head and Neck Surgical Oncology
- Dysphagia Assessment and Management
- Airway Management and Intubation Techniques
- Foreign Body Medical Cases
- Obstructive Sleep Apnea Research
- Congenital Ear and Nasal Anomalies
- Congenital Diaphragmatic Hernia Studies
- Lymphatic System and Diseases
- Central Venous Catheters and Hemodialysis
- Tuberous Sclerosis Complex Research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Facial Nerve Paralysis Treatment and Research
University of Washington
2016-2025
Seattle Children's Hospital
2016-2025
Pfizer (United States)
2023
University of Southern Mississippi
2022-2023
Emory University Hospital
2022
Qiagen (United Kingdom)
2018-2020
Seattle University
2003-2018
University of Kansas
2018
Washington University in St. Louis
2016
Binghamton University
2015
Infantile hemangiomas (IHs) are the most common tumors of childhood. Unlike other tumors, they have unique ability to involute after proliferation, often leading primary care providers assume will resolve without intervention or consequence. Unfortunately, a subset IHs rapidly develop complications, resulting in pain, functional impairment, permanent disfigurement. As result, clinician has task determining which lesions require early consultation with specialist. Although several recent...
<h3>Background</h3> During the past 50 years, changes in epidemiology of infectious diseases and capabilities medical technology have altered indications for, implications of, tracheotomy children. Given complexity health care that these patients subsequently require, monitoring performance this procedure patient outcomes across diverse US system is warranted. <h3>Objectives</h3> To characterize children who received tracheotomies 1997 to determine whether disposition mortality vary by...
Germinal center T follicular helper cells (GCTfh) in lymphatic tissue are critical for B cell differentiation and protective antibody induction, but whether GCTfh establish clonal derivatives as circulating memory is less understood. Here, we used markers expressed on GCTfh, CXCR5, PD1, ICOS, to identify potential CXCR5+CD4+ Tfh-like (cTfh) humans, investigated their functional phenotypes, diversity, ontogeny paired donor blood tonsils, after vaccination. Based receptor repertoire analysis,...
Abstract Crypto art is limited-edition digital art, cryptographically registered with a token on blockchain. Tokens represent transparent, auditable origin and provenance for piece of art. Blockchain technology allows tokens to be held securely traded without the involvement third parties. draws its origins from conceptual art—sharing immaterial distributive nature artworks, tight blending artworks currency rejection conventional markets institutions. The authors propose collection...
Central conducting lymphatic anomaly (CCLA) is one of the complex anomalies characterized by dilated channels, channel dysmotility and distal obstruction affecting drainage. We performed whole exome sequencing (WES) DNA from a four-generation pedigree examined consequences variant transfection mammalian cells morpholino rescue studies in zebrafish. WES revealed heterozygous mutation EPHB4 (RefSeq NM_004444.4; c.2334 + 1G>C) RNA-Seq demonstrated that destroys normal donor site, which leads to...
The objectives of the study were to describe speech outcomes in a large series patients undergoing Furlow palatoplasty for management velopharyngeal insufficiency and test whether preoperative gap size other patient characteristics significantly affect those outcomes.Data collected included age at time surgery, surgeon, type cleft, syndrome diagnosis, as determined by videonasendoscopy, postoperative perceptual assessments. Descriptive statistics generated ordinal logistic regression on...
Craniofacial anomalies (CFA) predispose children to airway obstruction. A retrospective study was conducted describe intervention required manage patients with craniofacial syndromes and diseases involving the midface mandible (i.e., Pierre Robin, Apert, Treacher Collins, Saethre-Chotzen, CHARGE, Nager, Stickler, Goldenhar, Pfeiffer). The type of intervention, duration associated physical medical conditions were evaluated. One hundred nine had charts available for review met inclusion...
Evaluate clinical and radiographic characteristics of spontaneously regressing lymphatic malformations ("lesions").Retrospective review 104 consecutive patients with cervicofacial lesions, 1-year follow-up.patient's age; lesion stage, location, characteristics; treatment. Data analysis using descriptive Fischer exact tests.Spontaneously lesions were identified in 13 (12.5%) patients. Five had utero which persisted at birth; presenting age the remaining eight was 2 to 138 months. Lesions...
<h3>Importance</h3> The optimal treatment for head and neck lymphatic malformations (LMs) is unknown. To our knowledge, this the first head-to-head comparison of primary surgery sclerotherapy condition. <h3>Objective</h3> compare as initial LMs. <h3>Design, Setting, Participants</h3> Retrospective cohort study including patients in 2 pediatric vascular anomaly programs receiving <h3>Interventions</h3> Primary or any subsequent therapy within 1 year. <h3>Main Outcomes Measures</h3> Treatment...
Successful management of fetal conditions in which airway obstruction is anticipated now possible because advances prenatal imaging and the development innovative techniques to secure before complete separation fetus from maternal circulation. Fetal ultrasonography magnetic resonance are complementary modalities assessment fetuses with potential obstruction. The ex utero intrapartum therapy (EXIT) procedure used delivery fetus. However, successful treatment who may need prolonged placental...
Objective Test the Velopharyngeal Insufficiency (VPI) Effects on Life Outcomes (VELO) instrument for validity, reliability, and responsiveness. Study Design Observational cohort. Setting Academic tertiary medical center. Subjects Children with VPI (n = 59) their parents 84) were prospectively enrolled from a pediatric clinic. Methods Pediatric speech language pathologists diagnosed using perceptual analysis rated severity intelligibility deficit (each as minimal, mild, moderate, or severe)....
While tremendous progress has been made in the dynamic crosslinking of polypropylene (PP) for plastic upcycling, efficacy addressing low-molecular-weight (MW) PP waste remains untapped. In this work, we demonstrate a simple and scalable method to convert brittle low-MW vitrimer materials with enhanced thermal mechanical properties, enabling their use circular upcycling. Different from most previous work employing small-molecule crosslinkers, prepare vitrimers (PPv) using polymeric containing...
To report our experience with endoscopic posterior cricoid split and rib graft insertion (EPCS/RG) in children glottic (PGS) subglottic stenosis (SGS).Retrospective analysis of case series, 1 to 2 year follow-up.Tertiary-care pediatric referral center.Ten consecutive patients undergoing EPCS/RG.EPCS/RG is a new procedure that expands the opening by dividing lamina endoscopically laser inserting cartilage through laryngoscope.Laryngeal function hospital stay.Successful decannulation two PGS...
1) To compare nasendoscopy (NE) and multiview fluoroscopy (MVF) in assessing velopharyngeal gap size; 2) to determine the relationship between these assessments insufficiency (VPI) severity.Retrospective review of consecutive patients with VPI at a tertiary care children's hospital, assessed NE MVF 1996 2003.177 subjects. areas were correlated (R = 0.34, 95% CI 0.26-0.41). In adjusted analysis, severity was associated with: area (OR 2.78, 1.96-3.95), 1.64, 1.37-1.95), 3) age <5 years 3.30,...
Objectives: To modify the existing 45-item Velopharyngeal Insufficiency (VPI) Quality-of-Life (QOL) instrument (VPIQL), to assess modified for reliability, and provide further validation.Design: Validation convenience sample from a previously conducted pilot study.Setting: Two academic tertiary referral medical centers.Participants: Deidentified data were used 29 patients with VPI control aged 5 17 years their parents.Main Outcome Measures: Patients parents completed VPIQL generic pediatric...
To develop general and site-specific treatment effect outcome measures to standardize the reporting of head neck lymphatic malformation (HNLM) treatments.Consensus statement/expert opinion.Multiple tertiary academic institutions.The modified Delphi method is an iterative process collecting expert opinions, refining opinions through discussion feedback, statistically aggregating using these aggregates generate consensus opinion in absence other data. The was used by a multi-institutional...
Lymphatic malformations (LMs) are congenital, nonneoplastic vascular associated with postzygotic activating PIK3CA mutations. The mutation spectrum within LMs is narrow, the majority having 1 of 3 hotspot Despite this relative genetic homogeneity, clinical presentations differ dramatically. We used molecular inversion probes and droplet digital polymerase chain reaction to perform deep, targeted sequencing in 271 affected unaffected tissue samples from 81 individuals isolated retrospectively...