A5061524606- Tracheal and airway disorders
- Vascular Malformations and Hemangiomas
- Respiratory and Cough-Related Research
- Tumors and Oncological Cases
- Head and Neck Surgical Oncology
- Airway Management and Intubation Techniques
- Vascular Malformations Diagnosis and Treatment
- Dysphagia Assessment and Management
- Voice and Speech Disorders
- Gastroesophageal reflux and treatments
- Teratomas and Epidermoid Cysts
- Esophageal and GI Pathology
- Ear and Head Tumors
- Neuroscience of respiration and sleep
- Ear Surgery and Otitis Media
- Head and Neck Anomalies
- Congenital Diaphragmatic Hernia Studies
- Obstructive Sleep Apnea Research
- Central Venous Catheters and Hemodialysis
- Vascular Tumors and Angiosarcomas
- Salivary Gland Tumors Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Sinusitis and nasal conditions
- Infant Health and Development
- Parvovirus B19 Infection Studies
George Washington University
2014-2024
Harvard University
2024
Temple University
2024
American Academy of Otolaryngology — Head and Neck Surgery
2024
Children's National
2014-2023
Georgetown University
2014
Children's Medical Center
2010
University of Iowa
1996-2008
Iowa City Public Library
1994-2005
University of Iowa Hospitals and Clinics
1995-2004
To determine 1) airway outcome of infants with laryngomalacia who do not undergo routine direct laryngoscopy (DL) and bronchoscopy (B), 2) the age at resolution laryngomalacia, and, 3) supraglottoplasty as a function type presence concomitant disease.Retrospective chart review.The records all diagnosed by flexible fiberoptic (FFL) between 1990 1998 in Department Otolaryngology--Head Neck Surgery, University Iowa (Iowa City, IA) were reviewed. The was designated new classification scheme...
<h3>Objective</h3> To describe and to determine the robustness of our study evaluating efficacy OK-432 (Picibanil) as a therapeutic modality for lymphangiomas. <h3>Design Setting</h3> Prospective, randomized trial parallel-case series at 13 US tertiary care referral centers. <h3>Subjects</h3> Thirty patients diagnosed having lymphangioma. Ages in 25 ranged from 6 months 18 years. Twenty-nine had lesions located head-and-neck area. <h3>Intervention</h3> Every patient received 4-dose injection...
Abstract Objectives: To determine the efficacy and safety of immunostimulant OK‐432 (Picibanil) as a treatment option in management children with cervicofacial lymphatic malformations. Study Design: A prospective, randomized, multi‐institutional phase II clinical trial at 27 U.S. academic medical centers. Methods: 182 patients malformations (LM) were enrolled between January 1998 November 2004. Of 151 complete case report forms, 117 randomized into immediate or delayed groups; 34...
Abstract Paradoxical vocal cord motion (PVCM) is characterized by the inappropriate adduction of true cords during inspiration. Multiple causes have been proposed for this group disorders, which share common finding mobile that adduct inappropriately inspiration and cause stridor approximation. Management disorders has complicated lack a classification scheme to include all types PVCM. We propose PVCM be classified according its underlying etiology recognize following disorder: 1 . brainstem...
To report the benefits and complications of subcutaneous interferon alfa-2a therapy for hemangiomas in children.Prospective nonrandomized trial.Tertiary care pediatric referral center.Twenty-four patients diagnosed with massive or life-threatening hemangiomas.Each patient received daily injections to a target dose 3 million U/m2 body surface area minimum 4 months. Nineteen completed have adequate follow-up.Clinical radiographic comparisons before, during, after therapy. Reduction hemangioma...
Controversies remain regarding the management of orbital cellulitis (OC). The objective this study was to examine outcomes patients admitted our institution for during a 7-year period.Case series with chart review.Tertiary referral pediatric hospital.Charts 465 consecutive OC admissions were reviewed presentation, imaging, medical and surgical treatment, outcome.Of these patients, 189 treated in emergency room 276 admitted. CT scan performed on 240 patients. Subperiosteal abscess (SPA) noted...
While propranolol is touted as superior to prednisolone for treating infantile hemangiomas (IH), a randomized clinical trial (RCT) comparing the outcome and tolerability of these medications symptomatic, proliferating IH has not been reported.To determine if oral more efficacious better tolerated than in feasibility conducting multi-institutional, RCT efficacy both medications.Phase 2, investigator-blinded, multi-institutional conducted 3 academic vascular anomalies clinics on 19 44 eligible...
<h3>Objective:</h3> To assess the efficacy of OK-432 sclerotherapy in treatment lymphangiomas. <h3>Design:</h3> Nonrandomized trial; follow-up, 4 to 29 months. <h3>Setting:</h3> Academic tertiary referral medical center. <h3>Patients:</h3> Six children with presumed lymphangiomas; age range at initial treatment, 1 month 7 years 10 <h3>Intervention:</h3> Fluoroscopically guided cyst aspiration, cystography, and injection OK-432. <h3>Outcome Measures:</h3> Clinical radiographic comparisons...
Picibanil (OK‐432) is a sclerosing agent derived from low‐virulence strain of Streptococcus pyogenes that induces regression macrocystic lymphangiomas. This report describes prospective, nonrandomized trial to evaluate the efficacy in treatment 13 affected children ranging age 1 94 months. On average, 4.1 fluoroscopically guided intracystic injections were performed per child, with an average total dose 0.56 mg Picibanil. As judged by physical examination and radiographic studies, 5 (42%)...
To develop general and site-specific treatment effect outcome measures to standardize the reporting of head neck lymphatic malformation (HNLM) treatments.Consensus statement/expert opinion.Multiple tertiary academic institutions.The modified Delphi method is an iterative process collecting expert opinions, refining opinions through discussion feedback, statistically aggregating using these aggregates generate consensus opinion in absence other data. The was used by a multi-institutional...
Laryngomalacia is a well-recognized cause of airway obstruction and inspiratory stridor in infants. As children grow become more active, laryngomalacia may manifest different, unexpected ways. Otherwise healthy athletes generate enough force to draw the aryepiglottic folds into endolarynx, causing subtotal glottic obstruction. This problem be overlooked or attributed asthma, lack fitness, functional abnormalities. The purpose this report review prevalence, diagnosis, treatment...
Exercise-induced laryngomalacia (EIL) is characterized by severe dyspnea, stridor, and mild wheezing unresponsive to prophylactic treatment with β-agonists cromolyn sodium. Symptoms develop extreme exertion, but resolve quickly as the degree of exercise decreased. Diagnosis requires flexible fiberoptic laryngoscopy before, during, after exercise. If diagnosis EIL confirmed during maximal exercise, laser epiglottoplasty effective in alleviating symptoms improving airway. However, because only...
Abstract Distal esophageal sensory nerves were stimulated in 17 anesthetized dogs divided into three age groups to determine the laryngeal, cardiovascular, and respiratory effects. Group I puppies 5 6 weeks of age, group II 8 19 III animals adult dogs. Marked laryngeal adductor activity laryngospasm observed puppies, while no or minimal adduction was seen younger Mean arterial pressure heart rate increased significantly ( P <.005) but remained unchanged >.4). This response is...
Objectives Develop multidisciplinary and international consensus on patient, disease, procedural, perioperative factors, as well key outcome measures complications, to be reported for pediatric airway reconstruction studies. Methods Standard Delphi methods were applied. Participants proposed items in three categories: 1) patient/disease characteristics, 2) procedural/intraoperative/perioperative 3) complications. Both general anatomic site‐specific elicited. also suggested specific...
Objective: To determine the utility of a pediatric multidisciplinary aerodigestive clinic (ADC) in treating recalcitrant conditions. Methods: Longitudinal observational study presenting complaints, evaluation, management, and outcome patients seen during 12 monthly ADCs beginning August 2013. Results: Fifty-five were by ADC team (otolaryngology/gastroenterology/pulmonology/speech pathology/nurse practitioner) followed for mean 17.6 months (range, 12-26 months). Mean age was 4.3 years 0.5-19...
Controversy exists about the optimal management of subperiosteal orbital abscesses (SPOAs) in pediatric patients. Some otolaryngologists advocate immediate surgical drainage while others recommend medical initially and reserve surgery for nonresponders. We hypothesized that patients who can be managed without have identifiable features on presentation may aid predicting their response to therapy.A retrospective chart review was performed all < or =18 years age were admitted University Iowa...
Paradoxical vocal fold motion (PVFM) is characterized by inappropriate adduction of folds during inspiration causing dyspnea. While anxiety suspected to be a predisposing factor, incidence has been understudied.