A5112319845- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Gastric Cancer Management and Outcomes
- Occupational and environmental lung diseases
- Childhood Cancer Survivors' Quality of Life
- Cancer Research and Treatments
- Nutrition and Health in Aging
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Oral health in cancer treatment
- Thyroid Cancer Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Cancer-related gene regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Click Chemistry and Applications
- Histone Deacetylase Inhibitors Research
- Nanocluster Synthesis and Applications
- Biosimilars and Bioanalytical Methods
- Cardiovascular and exercise physiology
University of Florida
2025
NorthShore University HealthSystem
2013-2023
University of Tennessee at Chattanooga
2021-2022
Erlanger Health System
2021
Epworth Hospital
2021
University of Chicago
2009-2018
Centre Hospitalier de l’Université de Montréal
2017
Ingalls Memorial Hospital
2016
University of Pennsylvania
2016
University of Chicago Medical Center
2011
The remarkably heterogeneous nature of lung cancer has become more apparent over the last decade. In general, advanced is an aggressive malignancy with a poor prognosis. discovery multiple molecular mechanisms underlying development, progression, and prognosis cancer, however, created new opportunities for targeted therapy improved outcome. this paper, we define "molecular subtypes" based on specific actionable genetic aberrations. Each subtype associated tests that drugs may potentially...
10009 Background: Treatment (tx) options are limited after GIST pts develop resistance to IM and SU. SOR inhibits KIT, VEGFR, PDGFR-β, BRAF kinases. In preclinical models, many secondary mutations, including IM-RES ATP-binding pocket IM/SU-RES activation loop mutations (Heinrich, Proc ASCO 2009). Methods: We performed a multi-center, phase II trial of in KIT-expressing who had disease progression (PD) on by RECIST. After FDA approval SU for GIST, the amended study required PD both Pts...
Patients with high-risk AML, defined as those advanced age, relapsed/refractory disease, unfavorable molecular and cytogenetic abnormalities, therapy-related myeloid neoplasm (t-MN) multiple medical co-morbidities tend to respond poorly standard cytarabine daunorubicin induction therapy have a poor prognosis. We performed retrospective analysis of an alternative regimen using high dose (HiDAC) mitoxantrone (MITO) administered 78 patients AML at The University Chicago from 2001 2008. primary...
<h3>Importance</h3> A proactive speech and language pathology (SLP) program is an important component of the multidisciplinary care patients with head neck squamous cell carcinoma (HNSCC). Swallowing rehabilitation can reduce rate feeding tube placement, thereby significantly improving quality life. <h3>Objective</h3> To evaluate initiation a SLP at single institution its association rates placement dietary intake in HNSCC. <h3>Design, Setting, Participants</h3> Cohort study tertiary...
4 Background: GIST pts who develop resistance to IM and SU have few therapeutic options. SOR inhibits KIT, VEGFR, PDGFR-β, BRAF kinases. In preclinical models, has activity against several IM-RES mutations that are resistant (Heinrich. ASCO 2009). Methods: We performed a multi-center, phase II trial of in unresectable, KIT-expressing had disease progression on by RECIST. After FDA approval for GIST, the study was amended 2/07 require after both SU. Pts received 400 mg orally twice daily. CT...
In recent years, there has been tremendous growth and interest in translational research, particularly cancer biology. This area of study clearly establishes the connection between laboratory experimentation practical human application. Though it is common for clinical data regarding patient specimens to be maintained separately, storage such heterogeneous one database offers many benefits as may facilitate more rapid accession provide researchers access greater numbers tissue samples.The...
2502 Background: Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV) types 6 & 11. RRP proliferates in the tract impacting breathing, swallowing, and voice carries a 1-4% risk of malignant transformation. There no curative therapy for RRP. Given tolerized host immune response against HPV, part through upregulation PD1:PDL1 axis, safety efficacy pembrolizumab (pembro) as novel treatment this benign tumor patient (pt) population was evaluated phase II...
2590 Background: Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV) types 6 & 11. RRP proliferates in the squamous epithelium lining tract impacting breathing, swallowing, and voice carries a 3-5% risk of malignant transformation. Given multi-focality disease tolerized host immune response against HPV, part through upregulation PD1:PDL1 axis, safety efficacy systemic pembrolizumab (pembro) as novel treatment for this benign tumor patient (pt) population...
To assess the safety and value of an exercise electrocardiography service for diagnosis suspected ischaemic heart disease to which general practitioners have direct access.Direct access a hospital was offered on trial basis 122 in defined urban area. Maximal tests were performed according modified Bruce protocol results dispatched promptly referring doctors who responsible subsequent management their patients.All practices north west Belfast (combined list size about 180,000) regional...
McArdle9s disease (myophosphorylase deficiency) results in the inability to metabolise skeletal muscle glycogen lactate. A patient with this condition developed angina and therefore offered a unique opportunity explore differential expression of defective myophosphorylase gene cardiac muscle.
An increasing amount of clinical data is available to biomedical researchers, but specifically designed database and informatics infrastructures are needed handle this effectively. Multiple research groups should be able pool share in an efficient manner. The Chicago Thoracic Oncology Database Consortium (CTODC) was created standardize collection facilitate the pooling sharing at institutions throughout across world. We assessed CTODC by conducting a proof principle investigation on lung...
7027 Background: Vascular endothelial growth factor (VEGF) signaling plays a key role in MM biology. In preclinical models, agents that target VEGF inhibit growth. phase II trials, several inhibitors have demonstrated modest activity pts. We performed multi-center trial of C, an oral tyrosine kinase inhibitor VEGFR 1, 2, 3 and PDGFR-α, Methods: Eligible pts had unresectable, histologically-confirmed MM, measurable disease, PS 0-1. No more than 1 prior regimen chemotherapy was permitted. C...
Article Tools CASE REPORTS OPTIONS & TOOLS Export Citation Track Add To Favorites Rights Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/OP.20.00734 JCO Oncology Practice - published online before print December 3, 2020 PMID: 33270522 Trastuzumab-Induced Thrombocytopenia Correlated by Drug-Dependent Platelet Antibodies Kathleen Sullivan , PharmD1xKathleen SullivanSearch for this author; Lynne S. Kaminer, MD1xLynne KaminerSearch David L. Grinblatt, MD1xDavid...
6080 Background: Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV) types 6 & 11. RRP proliferates in the tract impacting breathing, swallowing, and voice carries a 1-4% risk of malignant transformation.There no curative therapy for RRP. Given tolerized host immune response against HPV, safety efficacy pembrolizumab (pembro) as an alternative treatment this patient population was evaluated phase II clinical trial. Patient reported outcomes (PROs) were...