A5025209420- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Dysphagia Assessment and Management
- Oral health in cancer treatment
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Tracheal and airway disorders
- Sinusitis and nasal conditions
- Molecular Biology Techniques and Applications
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Lung Cancer Treatments and Mutations
- Voice and Speech Disorders
- Esophageal and GI Pathology
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Facial Nerve Paralysis Treatment and Research
- Cancer-related gene regulation
- Oral and Maxillofacial Pathology
- Cleft Lip and Palate Research
- Tumors and Oncological Cases
- Thyroid Cancer Diagnosis and Treatment
Rush University Medical Center
2021-2025
Harvard University
2024
Temple University
2024
American Academy of Otolaryngology — Head and Neck Surgery
2024
NorthShore University HealthSystem
2013-2023
University of Chicago
2008-2021
Rush University
2021
The University of Texas MD Anderson Cancer Center
2010-2015
University of Utah
2002
<h3>Importance</h3> Data support proactive swallowing therapy during radiotherapy (RT) or chemoradiotherapy (CRT) for pharyngeal cancers. The benefits of adherence to a regimen exercises and maintaining oral intake throughout treatment are reported, but independent effects unclear. <h3>Objective</h3> To evaluate the preventive exercise. <h3>Design</h3> Retrospective observational study. <h3>Setting</h3> University Texas MD Anderson Cancer Center, Houston. <h3>Patients</h3> study included 497...
Abstract BACKGROUND: Adenoid cystic carcinoma (ACC) is characterized by slow growth, frequent local recurrences, and distant metastasis (DM). However, these findings frequently are reported in patients with advanced‐stage tumors, but the outcomes of early‐stage tumors poorly defined. We sought to evaluate risk factors for development DM ACC. METHODS: retrospectively reviewed charts 60 who were diagnosed clinical (T1‐2/N0) ACC determine survival patients. RESULTS: was detected 12 (20%)...
Abstract Background The aim of the study was to examine prevalence dysphagia at population level in head and neck cancer (HNC) survivors. Methods Surveillance, Epidemiology, End Results‐Medicare claims among 16 194 patients with HNC (2002‐2011) were analyzed estimate 2‐year dysphagia, stricture, aspiration pneumonia, derive treatment‐ site‐specific estimates. Results Prevalence pneumonia 45.3% (95% confidence interval [CI]: 44.5‐46.1), 10.2% CI: 9.7‐10.7), 26.3% 25.6‐26.9), 8.6% 8.2‐9.1),...
Background Placement of gastrostomy tubes (g-tubes) in patients with hypopharyngeal cancers undergoing radiation and chemotherapy is generally empirically determined. We examined our experience to identify predictive factors for g-tube placement length dependence. Methods performed a retrospective review all primary cancer treated nonsurgical modalities at tertiary care center between 2002 2008. Rates dependence on enteral feedings were analyzed relationship multiple risk factors. Results...
Background Although many patients require nutritional support during radiotherapy or chemoradiotherapy for oropharyngeal cancer, little is known regarding the risk factors that predispose to gastrostomy tube (g-tube) placement and prolonged dependence, therapeutic interventions may abrogate these effects. Methods We performed a retrospective medical chart review of who were treated primary cancer at tertiary care center from 2003 2008. Patients had complete response site 1-year posttreatment...
Abstract Purpose: Human papillomavirus (HPV) is causally linked to oropharyngeal squamous cell carcinoma (OPSCC). Consensus guidelines recommend clinical exams and imaging in decreasing frequency as part of posttreatment surveillance for recurrence. Plasma tumor tissue modified viral (TTMV)-HPV DNA testing has emerged a biomarker which can inform disease status during surveillance. Experimental Design: This retrospective observational cohort study involved 543 patients who completed...
Traditionally IFN/STAT1 signaling is connected with an anti-viral response and pro-apoptotic tumor-suppressor functions. Emerging functions of a constitutively activated pathway suggest association aggressive tumor phenotype. We hypothesized that clones overexpress this are preferentially selected by the host microenvironment due to resistance STAT1-dependent cytotoxicity demonstrate increased metastatic ability combined genotoxic stress.Here we report B16F1 tumors grown in lungs syngeneic...
Adenocarcinoma is a rare tumor of the sinonasal tract. The purpose this study was to characterize single institution's experience with malignancy.Retrospective review performed patients adenocarcinoma tract from 1993 2009. Demographic data, disease presentation, treatment, and survival rates were collected evaluated.We identified 66 adenocarcinoma; 48 men 18 women. Average age at time diagnosis 57.1 years (range, 20-88 years), median follow-up 55.3 months 1-238 months). ethmoid sinus (38%)...
We examined outcomes in patients treated for radioactive iodine-induced sialadenitis (RAIS) and xerostomia with sialendoscopy.Data was prospectively collected all undergoing sialendoscopy RAIS from a single institution. Interventional details intraoperative findings were recorded. Qualitative data obtained through patient examination, telephone interviews, use of standard quality life questionnaire, Xerostomia Questionnaire. Quantitative who underwent sialometry.Twenty-six (24 women 2 men;...
The head and neck squamous cell carcinoma (HNC) landscape is evolving with human papillomavirus (HPV) being a rising cause of oropharynx (OPC). This study seeks to investigate national database for HPV-associated (HPV-OPC). Using the National Cancer Data Base, we analyzed 22,693 patients HPV-OPC known HPV status. Chi-square tests logistic regression models were utilized examine differences between positive negative OPC. 14,805 (65.2%) positive. Mean age at presentation was 58.4 years HPV-HNC...
Background Racial disparities in squamous cell carcinoma of the head and neck (HNSCC) negatively affect non‐Hispanic black (NHB) patients. This study was aimed at understanding how treatment is prescribed received across all HNSCC subsites. Methods With National Cancer Database, patients from 2004 to 2014 with surgically resectable HNSCCs, including tumors oral cavity (OC), oropharynx (OP), hypopharynx (HP), larynx (LX), were studied. The either upfront surgery or nonsurgical treatment....
// Xiaoli Wu 1,2,* , Mihir K. Bhayani 1,* Cristina T. Dodge 1 Milena S. Nicoloso 3 Yunyun Chen Xiaofeng Yan Makoto Adachi Ligy Thomas Chad E. Galer 4 Tilahun Jiffar Curtis R. Pickering Michael Kupferman Jeffrey N. Myers George A. Calin Stephen Y. Lai 1,5 Department of Head and Neck Surgery, University Texas M.D. Anderson Cancer Center, Houston, TX, USA 2 Division Gastroenterology, Tongji Hospital Medical College, Huazhong Science Technology, Wuhan, Hubei Province, China Experimental...
<h3>Importance</h3> The achievement of complete tumor resection with tumor-free margins is one the main principles oncologic surgery for head and neck squamous cell carcinoma (HNSCC). negative prognostic influence a positive margin (PM) across all subsites has been well established. National guidelines recommend use adjuvant chemoradiation therapy (CRT) in setting PM. <h3>Objective</h3> To determine incidence PM HNSCC multiple subsites, as factors associated its occurrence. <h3>Design,...
The National Comprehensive Cancer Network recommends imaging within 6 months after treatment for head and neck cancer (HNC). Further is recommended only if the patient has symptoms or abnormal findings on physical examination. However, in many instances, asymptomatic patients continue to have evaluations.To assess practice patterns surveillance with HNC evaluate costs associated these practices.This single-institution retrospective economic evaluation study screened 435 identify newly...
Abstract Objective Medical literature identifies stark racial disparities in head and neck cancer (HNC) the United States, primarily between non‐Hispanic white (NHW) black (NHB) populations. The etiology of this disparity is often attributed to inequitable access health care socioeconomic status (SES). However, other contributors have been reported. We performed a systematic review better understand multifactorial landscape driving HNC. Data Sources A was conducted Covidence following...
Abstract Background Definitive surgery is recommended for oral cavity squamous cell carcinoma (SCC). The purpose of this study was to present our assessment the disparities in treatment selection SCC. Methods Non‐Hispanic white and non‐Hispanic black patients with SCC were identified National Cancer Database (NCDB). Regression models used estimate relative risk (RR) receiving absolute difference between patients. Results There 82.3% who received surgery, compared 64.2% ( P < .001). less...