A5038774694- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Multiple Myeloma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Cervical Cancer and HPV Research
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Economic and Financial Impacts of Cancer
- Palliative Care and End-of-Life Issues
- CAR-T cell therapy research
- Cancer Treatment and Pharmacology
- Circular RNAs in diseases
- Ethics in medical practice
- Hematological disorders and diagnostics
- Pericarditis and Cardiac Tamponade
- Case Reports on Hematomas
- Complement system in diseases
- CNS Lymphoma Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Immunodeficiency and Autoimmune Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Telemedicine and Telehealth Implementation
- Ethnobotanical and Medicinal Plants Studies
University of Charleston
2024
University Medical Center
2024
Medical University of South Carolina
2023-2024
University of Arkansas for Medical Sciences
2018-2021
University of Arkansas Medical Center
2020
Winthrop Rockefeller Foundation
2020
Micro Labs (India)
2010
Bundelkhand University
2010
Holy Family Hospital
2000
Abstract Purpose: Human papillomavirus (HPV) is causally linked to oropharyngeal squamous cell carcinoma (OPSCC). Consensus guidelines recommend clinical exams and imaging in decreasing frequency as part of posttreatment surveillance for recurrence. Plasma tumor tissue modified viral (TTMV)-HPV DNA testing has emerged a biomarker which can inform disease status during surveillance. Experimental Design: This retrospective observational cohort study involved 543 patients who completed...
Abstract Multiple myeloma (MM) patients frequently attain a bone marrow (BM) minimal residual disease (MRD) negativity status in response to treatment. We identified 568 who achieved BM MRD following autologous stem cell transplantation (ASCT) and maintenance combination therapy with an immunomodulatory agent proteasome inhibitor. was evaluated by next-generation flow cytometry (sensitivity of 10−5 cells) at 3- 6-month intervals. With median follow-up 9.9 years from diagnosis (range,...
Cardiac complications associated with influenza infection can occur either via a direct effect of the virus on heart or through exacerbation preexisting cardiovascular disease. We present case 57-year-old man acute complicated by pericardial effusion and cardiac tamponade.A white presented to Emergency Department sudden onset severe, nonexertional, retrosternal, pressure-like chest pain for few hours fever muscle aches 2 days. The patient was initially admitted because suspected coronary...
Older age is a melanoma risk factor. Elderly individuals are likelier to have immunosenescence, which could help cells escape immune surveillance. Hence, it believed that elderly people cannot mount potent response checkpoint inhibitors eliminate melanoma.To investigate age-related differences in the time progression, overall survival, and immunotherapy-related adverse events among patients with metastatic who received inhibitors.We retrospectively identified at our institution between...
Hemophagocytic lymphohistiocytosis (HLH) is an underrecognized disorder due to the variability of its presentation and fact that in adults, diagnosis based on cumbersome, pediatric-based criteria. Data regarding demographics, underlying causes, clinical features, laboratory results, complications, treatments received, outcomes were collected analyzed 41 patients who diagnosed treated at University Arkansas for Medical Sciences between 2007 2019. In this group, 51% male, median age was 47...
Acquired inhibitors of coagulation are a group rare but potentially life-threatening blood disorders characterized by the presence autoantibodies directed against clotting factor. Autoantibody factor VIII is most common form inhibitor, condition also known as acquired hemophilia A. We present clinical series nine patients diagnosed and treated for A at our institution. Among these patients, there were five men four women with median age 64 years. All presented bleeding diathesis. Factor...
Intravascular large B-cell lymphoma is a rare malignancy characterized by the presence of cells within lumen blood vessels. The annual incidence cases fewer than 0.5 per 1,000,000. It usually affects elderly with an average age diagnosis around 70 years. Due to absence in peripheral smear and lymphadenopathy, it difficult diagnose these cases. Although central nervous system skin are commonly involved organs, they can involve any organ system. Prompt initiation treatment very crucial as...
<p>Supplementary Figure S1: Case examples of false negative TTMV-HPV DNA results identified during surveillance</p>
<p>Supplementary Figure S1: Case examples of false negative TTMV-HPV DNA results identified during surveillance</p>
<div>Abstract<p>Background: Human papillomavirus (HPV) is causally linked to oropharyngeal squamous cell carcinoma (OPSCC). Consensus guidelines recommend clinical exams and imaging in decreasing frequency as part of post-treatment surveillance for recurrence. Plasma tumor tissue modified viral (TTMV)-HPV DNA testing has emerged a biomarker which can inform disease status during surveillance. Methods: This retrospective observational cohort study involved 543 patients who...
Abstract Purpose: Detecting minimal residual disease (MRD) has emerged as a key strategy in oncology for identifying those at high risk of relapse. Circulating tumor tissue modified viral (TTMV)-HPV DNA promising biomarker HPV-driven oropharyngeal cancer. Prior studies have largely focused on detection beyond three months post-treatment. This study evaluated the ability TTMV-HPV to detect MRD immediately after initial or salvage treatment. Patients and Methods: IRB-approved, retrospective...
Hemolytic uremic syndrome (HUS) is a type of thrombotic microangiopathy (TMA) defined as triad non-immune microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Shiga toxin (Stx) or diarrhea-associated HUS one the major categories secondary HUS, which seen predominantly in children regarded rare entity adult population. We present two cases sporadic Stx females. Our first case 74-year-old Caucasian woman who presented to emergency department with nausea, vomiting,...
Patients with renal cell carcinoma (RCC) often remain asymptomatic until the disease is advanced, about 25% presenting at an advanced stage. We present a case of metastatic RCC treated combination ipilimumab and nivolumab complete radiological pathological response. Currently, preferred option for intermediate- poor-risk patients clear stage IV RCC.
Goel, Akshay1; Subramany, Swathi1; Wayne, Michelle1; Ibanez, Nicholas1; Pandey, Yadav1; Goraya, Harmeen1 Author Information
1 Background: Advance care planning (ACP), which includes advance directive (AD) completion, ensures that patients receive is consistent with their beliefs and preferences. ACP particularly important to cancer as they have high rates of hospitalization mortality. However, AD completion for oncology been reported be low 10%. We sought evaluate barriers improve in hospitalized our institution. Methods: 63 admitted inpatient unit were surveyed. A multi-disciplinary team, consisting resident...
8514 Background: Attainment of MRD negativity in multiple myeloma (MM) patients is increasingly considered an optimal therapeutic endpoint, but little known about the evolution those who achieve this milestone. We investigated clinical implication loss or conversion with ≥VGPR. Methods: identified and followed 606 achieving a sustained ≥VGPR bone marrow negativity(≥ 2 consecutive reading) following treatment on total therapy protocol median follow-up 10 y. All patient had negative PET MRI...
Introduction: Hypercalcemia is relatively common in clinical practice. Primary hyperparathyroidism and malignancy accounts for more than 90 percent of all cases hypercalcemia. Milk alkali syndrome which hypercalcemia classically caused by ingestion large amount calcium absorbable was once virtually disappeared as a cause has emerged third leading We present case secondary to carbonate tablets resulting milk syndrome.Case presentation: Patient 45-year-old female with history gastroesophageal...
Abstract Introduction: Indeterminate results of clinical or imaging examinations are common across the care continuum, and decisions made can lead to overtreatment psychological financial harms for patient. Additionally, due emergence highly sensitive circulating tumor DNA assays, an indeterminate status also arise when molecular detection precedes radiological evidence recurrence a period time. We recently reported &gt;99% negative &gt;95% positive predictive value tissue modified...
<div>AbstractPurpose:<p>Human papillomavirus (HPV) is causally linked to oropharyngeal squamous cell carcinoma (OPSCC). Consensus guidelines recommend clinical exams and imaging in decreasing frequency as part of posttreatment surveillance for recurrence. Plasma tumor tissue modified viral (TTMV)-HPV DNA testing has emerged a biomarker which can inform disease status during surveillance.</p>Experimental Design:<p>This retrospective observational cohort study involved...
<p>Supplementary Figure S1: Case examples of false negative TTMV-HPV DNA results identified during surveillance</p>
<p>Supplementary Figure S1: Case examples of false negative TTMV-HPV DNA results identified during surveillance</p>