A5034866239- Head and Neck Cancer Studies
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Archaeology and Natural History
- Cervical Cancer and HPV Research
- Cancer Genomics and Diagnostics
- Botany, Ecology, and Taxonomy Studies
- Oral Health Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Virus-based gene therapy research
- Radiomics and Machine Learning in Medical Imaging
- American Environmental and Regional History
- COVID-19 and healthcare impacts
- Cancer survivorship and care
- Palliative Care and End-of-Life Issues
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
The US Oncology Network
2023-2024
Christiana Care Health System
2021-2023
Abstract Purpose: Human papillomavirus (HPV) is causally linked to oropharyngeal squamous cell carcinoma (OPSCC). Consensus guidelines recommend clinical exams and imaging in decreasing frequency as part of posttreatment surveillance for recurrence. Plasma tumor tissue modified viral (TTMV)-HPV DNA testing has emerged a biomarker which can inform disease status during surveillance. Experimental Design: This retrospective observational cohort study involved 543 patients who completed...
Background: The COVID-19 pandemic caused significant disruptions in cancer care, and preliminary research suggests that these are associated with increased levels of psychosocial distress among survivors. purpose this study was to offer a descriptive report the functioning, perceived risk fear progression, impact experiences unique, high-risk patient cohort: breast survivors whose treatment delayed and/or changed due pandemic. Methods: This cross-sectional included 50 women dual carcinoma...
It has long been known that there was a lake in Death Valley during the Pleistocene (Lake Manly), but, because evidence of its presence seemed meager, age had put at Tahoe (early Wisconsin). Later studies have suggested may two major stages as did Lakes Bonneville and Lahontan: first time, second Tioga (late Wisconsin) time. The stage, represented particularly by Manly Terrace, largest terrace remnant now valley, is correlated with Provo Dendritic Terrace above-mentioned lakes. On several...
Abstract Background: PRMT5 catalyzes symmetric arginine dimethylation of protein substrates with important roles in cancer cell growth/survival, including glioblastoma (GBM) cells. PRT811 is a brain penetrant, potent, selective, oral inhibitor preclinical efficacy GBM orthotopic model (Zhang AACR 2020). An open-label Phase I study patients (pts) advanced solid tumors and recurrent high-grade glioma (NCT04089449) ongoing. Dose escalation results are presented herein. Materials Methods: This...
<p>Supplementary Figure S1: Case examples of false negative TTMV-HPV DNA results identified during surveillance</p>
<p>Supplementary Figure S1: Case examples of false negative TTMV-HPV DNA results identified during surveillance</p>
<div>Abstract<p>Background: Human papillomavirus (HPV) is causally linked to oropharyngeal squamous cell carcinoma (OPSCC). Consensus guidelines recommend clinical exams and imaging in decreasing frequency as part of post-treatment surveillance for recurrence. Plasma tumor tissue modified viral (TTMV)-HPV DNA testing has emerged a biomarker which can inform disease status during surveillance. Methods: This retrospective observational cohort study involved 543 patients who...
Abstract Purpose: Detecting minimal residual disease (MRD) has emerged as a key strategy in oncology for identifying those at high risk of relapse. Circulating tumor tissue modified viral (TTMV)-HPV DNA promising biomarker HPV-driven oropharyngeal cancer. Prior studies have largely focused on detection beyond three months post-treatment. This study evaluated the ability TTMV-HPV to detect MRD immediately after initial or salvage treatment. Patients and Methods: IRB-approved, retrospective...
6083 Background: Elderly patients with head and neck cancer (HNC) represent a growing population that would benefit from novel, less toxic approaches. Recent negative trial results adding ICI to chemo-RT for LAHNSCC (Javelin, Keynote 412) suggest total nodal irradiation may create an immunosuppressive tumor microenvironment (TME), blunting the efficacy of ICI. This study was undertaken use pulsed QUAD SHOT as in-situ vaccine by stimulating TME prior delivery ICI, excluding elective sites,...
Abstract Introduction: Indeterminate results of clinical or imaging examinations are common across the care continuum, and decisions made can lead to overtreatment psychological financial harms for patient. Additionally, due emergence highly sensitive circulating tumor DNA assays, an indeterminate status also arise when molecular detection precedes radiological evidence recurrence a period time. We recently reported &gt;99% negative &gt;95% positive predictive value tissue modified...
<div>AbstractPurpose:<p>Human papillomavirus (HPV) is causally linked to oropharyngeal squamous cell carcinoma (OPSCC). Consensus guidelines recommend clinical exams and imaging in decreasing frequency as part of posttreatment surveillance for recurrence. Plasma tumor tissue modified viral (TTMV)-HPV DNA testing has emerged a biomarker which can inform disease status during surveillance.</p>Experimental Design:<p>This retrospective observational cohort study involved...
<p>Supplementary Figure S1: Case examples of false negative TTMV-HPV DNA results identified during surveillance</p>
<p>Supplementary Figure S1: Case examples of false negative TTMV-HPV DNA results identified during surveillance</p>
<div>Abstract<p>Background: Human papillomavirus (HPV) is causally linked to oropharyngeal squamous cell carcinoma (OPSCC). Consensus guidelines recommend clinical exams and imaging in decreasing frequency as part of post-treatment surveillance for recurrence. Plasma tumor tissue modified viral (TTMV)-HPV DNA testing has emerged a biomarker which can inform disease status during surveillance. Methods: This retrospective observational cohort study involved 543 patients who...